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All Journal Majalah Kedokteran Andalas Majalah Ilmiah METHODA
Refa Rahmaddiansyah
Faculty of Medicine, Universitas Andalas
Agriculture, Biological Sciences & Forestry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health

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Bioaktivitas Antikanker dari Quercetin Bertarget Src dalam Terapi Kanker Paru Bukan Sel Kecil Refa Rahmaddiansyah; Sukarsi Rusti; Dessy Arisanty
Majalah Kedokteran Andalas Vol 45, No 4 (2022): Online October 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v45.i4.p667-679.2022

Abstract

Kanker paru adalah salah satu jenis kanker yang paling umum dengan penyebab utama kematian akibat kanker di seluruh dunia. Kanker paru bukan sel kecil (NSCLC) adalah jenis kanker yang menyumbang sekitar 85% dari semua kejadian kanker paru-paru. Ini juga memiliki prognosis dan pilihan pengobatan yang buruk. Src adalah salah satu target paling efektif yang terkait dengan pengembangannya. Penelitian ini merupakan studi tinjauan pustaka dengan menggunakan data dari penelitian asli berdasarkan studi in vitro dan in vivo. Hasil penelitian menunjukkan bahwa Que menghambat induksi proliferasi dan metastasis sel NSCLC dengan menekan ekspresi Src yang kemudian menghambat jalur pensinyalan Fn14/NF-κB. Quercetin juga mengganggu pensinyalan faktor nuklir kappa B (NF-κB) yang mengatur ekspresi beberapa gen yang terlibat dalam karsinogenesis, peradangan, dan sitoprotektif. Dengan membungkam Src, metastasis kanker paru-paru akan berkurang. Ketika Src dihambat, sel-sel yang dilepaskan mengalami anoikis sehingga terjadi kematian sel dengan kecepatan mekanisme penghambatan. Dengan demikian, dapat disimpulkan bahwa quercetin berperan sebagai antikanker melalui penghambatan proliferasi tumor, metastasis, dan angiogenesis melalui jalur pensinyalannya pada sel kanker paru. Diharapkan ada penelitian berkelanjutan untuk meningkatkan status kesehatan global, khususnya pada pasien NSCLC.
Balanced Nutrition Education Based on the "Isi Piringku" Principle at the Outpatient Clinic of Rokan Hulu Regional General Hospital: A Promotive Effort in the Prevention of Non-Communicable Diseases Refa Rahmaddiansyah; Sukarsi Rusti; Maria Nurlita; Afridel Fiane; Hertaria Yosephine Rajagukguk
Majalah Ilmiah METHODA Vol. 16 No. 1 (2026): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methoda.Vol16No1.pp63-68

Abstract

Non-communicable diseases (NCDs) such as diabetes mellitus, hypertension, and obesity constitute a significant public health problem in Indonesia. One of the principal modifiable risk factors is an unhealthy dietary pattern. Balanced nutrition education based on the "Isi Piringku" principle represents a promotive strategy to improve nutrition literacy in the community. This activity aimed to enhance the knowledge and understanding of patients and their family members attending the Outpatient Clinic of Rokan Hulu Regional General Hospital regarding the principles of balanced nutrition and the application of the "Isi Piringku" concept in daily life. The education session was conducted on September 8, 2025, through a visual presentation using PowerPoint media explaining the "Isi Piringku" principle, followed by a discussion and question-and-answer session with healthcare personnel. Evaluation was carried out qualitatively through observation of participant engagement throughout the activity. The activity demonstrated active participant involvement during the discussion session, with various questions and responses reflecting interest in and comprehension of the material. The visual and interactive approach was considered capable of improving participants’ information retention. Nutrition education using a visual and participatory approach may represent a relevant method for implementation in healthcare facilities as part of a promotive strategy for NCD prevention. In the future, quantitative measurement is required to evaluate the long-term impact of similar interventions.
Classic Hand, Foot, And Mouth Disease in A 4-Year-Old Girl at An Indonesian District Hospital: A Case Report and Focused Narrative Review on Diagnosis and Therapeutic Stewardship Refa Rahmaddiansyah; Ahmad Lutfi; Aziza AR; Sukarsi Rusti
Majalah Ilmiah METHODA Vol. 16 No. 2 (2026): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methoda.Vol16No2.pp156-162

Abstract

Background: Hand, foot, and mouth disease (HFMD) is a highly contagious enteroviral illness that most commonly affects children younger than five years. Although the classic clinical pattern is readily recognizable, changing viral epidemiology and atypical cutaneous phenotypes may complicate diagnosis and contribute to unnecessary testing or treatment. Case presentation: A 4-year-old previously healthy girl presented to the emergency department of a district hospital in Rokan Hulu, Indonesia, with three days of intermittent low-grade fever, mild upper respiratory symptoms, painful oral ulcers, and a vesiculopapular eruption involving both palms and soles. She was hemodynamically stable, had preserved peripheral perfusion, no respiratory distress, and no neurologic abnormalities. Examination showed three small sublingual ulcers and bilateral palmar and plantar vesicles with superficial erosions and erythema. The diagnosis of classic HFMD was made clinically; herpangina and varicella were considered less likely. She received outpatient treatment and caregiver counselling regarding hydration, nutrition, hygiene, surface disinfection, and warning signs. Conclusion: The case illustrates the diagnostic value of morphology and distribution in classic HFMD and the need for therapeutic stewardship. In uncomplicated disease, supportive care is the standard; microbiologic testing, antibiotics, and unproven antiviral or immunomodulatory therapies are generally unnecessary unless atypical features, severe disease, or bacterial superinfection is present.
Bioelectric Potential of Phaleria macrocarpa (Mahkota Dewa) Fruit: Voltage Measurement and Application as an Alternative Power Source Refa Rahmaddiansyah; Aulia Putri Nazhira; Afif Dafakusumah; Fettriwanti; Sukarsi Rusti
Majalah Ilmiah METHODA Vol. 15 No. 2 (2025): Majalah Ilmiah METHODA
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/methoda.Vol15No2.pp201-205

Abstract

The use of electrical energy from year to year is increasing, but the source of electrical energy has limitations. This electrical energy crisis must be addressed immediately, one of which is using environmentally friendly and renewable fuels. One of the environmentally friendly sources of electricity is the fruit of the mahkota dewa (Phaleria macrocarpa). The purpose of writing this paper is to investigate the benefits of the crown of the gods as an alternative source of electrical energy. The subject of this research is the crown of the god fruit with the criteria that the fruit is ripe which is marked with a red color which will be used as an alternative source of electrical energy to replace batteries. In addition to its medicinal properties, the results of this study indicate that the crown of the god fruit contains alkaloid compounds (bases) that can generate electricity. The electric voltage generated from the four pieces of the crown of the god can reach a voltage of 1.8 V. Meanwhile, the current generated from one crown of the god is very small and only produces a voltage of 0.9 V. The use of the crown of the gods as a source of electrical energy has a number of advantages in addition to some of the disadvantages it has. Based on the results of research on the power source from the crown of the god, it can be concluded that the hypothesis that there are benefits of the crown of the god as an alternative source of electrical energy is acceptable.
Co-Authors Afif Dafakusumah Afridel Fiane Ahmad Lutfi Aulia Putri Nazhira Aziza AR Dessy Arisanty Fettriwanti Hertaria Yosephine Rajagukguk Maria Nurlita Nisriinaa Yurensi Rauza Sukma Rita Sukarsi Rusti Sukarsi Rusti Sukarsi Rusti Sukarsi Rusti Wahida Rahmi