Article Per Year (5 Year)
p-Index From 2020 - 2025
0.23
P-Index
This Author published in this journals
All Journal Journal Syifa Sciences and Clinical Research (JSSCR)
Zulfianto Djufri
Jurusan Farmasi Fakultas Olahraga dan Kesehatan, Universitas Negeri Gorontalo, Jl. Jenderal Sudir
Chemistry Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Uji Aktivitas Antidiabetes Ekstrak Etil Asetat Daun Lamun (Enhalus acoroides) Pada Mencit (Mus musculus) Hamsidar Hasan; A.Mu'thi Andy Suryadi; Zulfianto Djufri
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.15379

Abstract

Diabetes mellitus is a severe condition, chronic in nature, that occurs when there is an increase in blood glucose levels (GDS) 200 mg/dL or hyperglycemic conditions. Some plants are reported to have anti-diabetic effects. One of the examples is seagrass (Enhalus acoroides), which has α-glucosidase enzyme inhibitory effects in vitro. The community often uses it as traditional medicine. This present work explores the anti-diabetic activity of ethyl acetate extract of seagrass (Enhalus acoroides) leaves against male mice (Mus musculus) charged with 90% sucrose solution. It employed the oral sucrose tolerance test (OSTT) methodology. Activity tests on mice were carried out in five treatment groups, namely: group I or a negative control (Na-CMC 1% w/v); group II or a positive control (acarbose); group III (ethyl acetate extract dose 50 mg/kg BW); group IV ( ethyl acetate extract at a dose of 150 mg/kg BW), and; group V (ethyl acetate extract at a dose of 250 mg/kg BW). All data were analyzed by using a one-way ANOVA statistical test. The results show that the ethyl acetate extract of seagrass leaves can inhibit the absorption of sucrose, in which the most significant total inhibition occurred at a dose of 250 mg/kg BW, i.e., 68 mg/dL. A substantial inhibition was also found at a dose of 150 mg/kg BW, which was 82 mg/dL and at a dose of 50 mg/dL or 103 mg/dL. In conclusion, the ethyl acetate extract of seagrass leaves has anti-diabetic activity.
Co-Authors A.Mu'thi Andy Suryadi Hamsidar Hasan