PUDJO HAGUNG WIDJAJANTO, PUDJO HAGUNG
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Leukemia Myeloblastik Akut: Luaran Terapi di RSUP DR. Sardjito, Yogyakarta, 2004-2008 NURMALASARI, SITI AURELIA; WIDJAJANTO, PUDJO HAGUNG; MULATSIH, SRI; PURWANTO, IGNATIUS
Indonesian Journal of Cancer Vol 6, No 2 (2012): Apr - Jun 2012
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.115 KB)

Abstract

Latar belakang: insiden Leukemia Myeloblastik Akut (LMA) anak meningkat dari tahun ke tahun, namun keberhasilan terapi masih rendah. Tujuan: mengetahui overall survival pasien LMA anak dan faktor prognosis yang mempengaruhi luaran terapi di RSUP DR. Sardjito Yogyakarta, Januari 2004 - Desember 2008. Metode: anak usia < 15 tahun dan baru terdiagnosis LMA dimasukkan dalam penelitian ini. Faktor prognosis meliputi jumlah lekosit saat diagnosis dan status gizi. Analisis overall survival menggunakan metode Kaplan-Meier. Faktor prognosis dianalisis menggunakan regresi Cox. Hasil: terdapat 56 (63,6%) pasien menjalani kemoterapi dengan modifikasi protokol NOPHO-AML 93. Didapatkan 19 (33,9%) pasien meninggal, 4 (7%) relaps, 32 (57%) drop out, dan 1 (2%) survive. Median survival 3,05 bulan (10 hari - 2,8 tahun). Overall survival 3 tahun adalah 19 ± 10%. Kesimpulan: prognosis LMA anak di institusi kami masih buruk. Progresivitas penyakit, toksisitas obat, dan belum memadainya supportive care berperan dalam kematian pasien LMA anak.Kata kunci: LMA anak, faktor prognosis, overall survival.
A province-wide childhood malignancy profiles in Indonesia (2010-2019): Yogyakarta Pediatric Cancer Registry Supriyadi, Eddy; Purwanto, Ignatius; Armytasari, Inggar; Ritter, Julie; Widjajanto, Pudjo Hagung; Veerman, Anjo JP
Paediatrica Indonesiana Vol 63 No 4 (2023): July 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.4.2023.226-37

Abstract

Background The global burden of childhood cancer is poorly quantified, but it is estimated that 80% of all children with cancer live in low- and middle-income countries with cure rates of childhood cancer far lower than in high-income nations. Objective To describe the Yogyakarta Region pediatric cancer profile from 2010-2019 and compare it to that of a 2000-2009 study in the same setting. Methods This retrospective study of childhood cancer was conducted in patients aged £18 years and diagnosed in Dr. Sardjito General Hospital from 2010 to 2019. Pediatric cancer patient data were collected from hospital hardcopy and electronic medical records. An estimated annual average incidence rate of childhood cancer was calculated and the number of patients by their regions of origin were visualized. The number of childhood malignancies recorded is also compared by the number found in 2000-2009 study. Results There were 1,839 new cases registered in Yogyakarta Pediatric Cancer Registry during the study period. The mean age at diagnosis was 6.3 years and male-to-female ratio was 1.4: 1.0. Fifty-six% of cancers were diagnosed in the 0-5-years age group. The most common diagnosis category was leukemia, which accounted for 60% of all childhood malignancies. The three most common diagnoses were acute lymphoblastic leukemia (44%), acute myeloid leukemia (12%), and retinoblastoma (7%). The annual average incidence rates of leukemia and solid tumors were 26.8 and 17.5 per million, respectively. The number of patients registered in 2000-2009 study was 1,124 case. Therefore, there was an increase of 63.6% in the number of childhood malignancies registered in 2010-2019 compared to the 2000-2009 study. Conclusion There is an increase in the number of childhood malignancies registered in 2010-2019 compared to the 2000-2009 study. The number of patients referred to our hospital increased, indicating a more inclusive registry, better referral system, and better access to health care facility.
Circumcision in subject with hemophilia: the Yogyakarta Method Widjajanto, Pudjo Hagung; Hadi, Nurul; Saputro, Ivan Onggo; Wibowo, Agus; Budiono, Nur; Tusino, Agus; Sutowo, David Wijaya
Paediatrica Indonesiana Vol 64 No 3 (2024): May 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.3.2024.244-9

Abstract

Background Circumcision is one of the most common surgical procedures in boys in Indonesia. In cases patient with hemophilia (PWH), doctors tend to avoid this procedure due to increased bleeding tendency. In 2007, we developed a protocol for clotting factor concentrate (CFC) administration for circumcision in SWH, namely, the “Yogyakarta Method.” Objective To evaluate the outcomes of the Yogyakarta Method for circumcising PWH. Methods This descriptive study was based on medical records of PWH who underwent circumcision at Dr. Sardjito Hospital (DSH), Yogyakarta and 3 surrounding hospitals under DSH supervision from 2008-2017 and 2018-2022. Diagnoses of hemophilia were based on clinical findings and factor assays. Subjects with hemophilia A received factor VIII (25 IU/kg/dose) and those with hemophilia B received factor IX (50 IU/kg/dose) before, during and after the procedure. In addition, patients received tranexamic acid (15 mg/kg/dose). Circumcision was performed by a pediatric surgeon or urologist. Results From 2008-2017, 28 PWH underwent circumcision, 14/28 of whom were in DSH. Twenty-six patients had hemophilia A and 2 had hemophilia B. Their severities were mild (12 subjects), moderate (10), and severe (6). Subjects’ median age was 10.5 (5-19) years and their median CFC use was 8 (range 7-10) doses in hemophilia A and 4 (range 4-5) doses in hemophilia B patients. Three of 28 PWH had bleeding episodes after the procedure. Following the encouraging results from the initial 2008-2017 study period, most of PWH circumcised in 2018-2022 underwent the procedure in the same 3 district hospitals rather than at DSH (21/28 subjects), and had similar CFC consumption. Only 1 bleeding episode occurred after the procedure during the second study period. Conclusion The Yogyakarta method is safe and sufficient to control bleeding in circumcision of PWH. This method is also suitable in a district hospital setting.