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All Journal Indonesian Journal of Cancer JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
ISKANDAR ALI, ISKANDAR
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Case Report of Malignant Lymphoma of the Breast ASHARIATI, AMI; DJATMIKO, ARIO; ALI, ISKANDAR
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Four cases of breast malignant lymphoma (BML) are discussed, diagnosed and managed. The issue of diagnosing BML, showed how different these 4 cases were, in particular in the imaging ultrasonography (USG). Generally, the USG of ductal carcinoma is irregular solid mass, while the USG of BML is compliant with cystic forms. Case 1 is 68 years old woman with left breast tumor. USG revealed hypoechoic lesion in the left breast with FNA result of malignant lymphoma, but still differential diagnosis with ductal carcinoma of the breast Mamma. Case 2 is a 52 years old woman who had left breast tumor. The USG revealed malignant lesion, left axilla node positive, although FNA result was ductal carcinoma, after simple mastectomy, the frozen section revealed malignant lymphoma. Case 3 is a 51 years old woman, USG of the left breast revealed malignant lesion, left axilla node positive, and excision biopsy revealed non-Hodgkin’s lymphoma diffuse large cell. Case 4 is a 51 years old woman, the USG revealed irregular hypoechoic lesions in both breasts and left supraclavicula node 5 mm. Core biopsy revealed bilateral breast non Hodgkin’s lymphoma subcutaneous, T-cell lymphoma. The therapeutic management of breast lymphoma is controversial and is not fully established yet. A strategy consisting of three cycles of CHOP followed by involved-field radiation therapy is reportedly superior to eight cycles of CHOP alone.
Penanganan nipple discharge di RS Onkologi Surabaya DJATMIKO, ARIO; RISTANTO, WIWIEN; ALI, ISKANDAR
Indonesian Journal of Cancer Vol 4, No 4 (2010): Oct - Dec 2010
Publisher : "Dharmais" Cancer Center Hospital

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Nipple secretion in nonlactating period often creates anxiety. Frequently this was the reason women came to hospital to be examined. Not all nipple secretion can be defined as nipple discharge. The terminology of nipple discharge is spontaneous fluid secretion from single duct in the nipple in nonlactating women. Generally, nipple discharge is related to non cancerous cause. Yet, many researchers stated that nipple discharge is a sign of breast malignancy. Therefore, accurate diagnostic is vital to differentiate the normal and abnormal nipple discharge. In final analysis, there must be a correct procedure to decide whether nipple discharge is to be operated or not. From January 2007 to December 2009, 10,033 new patients came to Surabaya Oncology Hospital with breast complaints. It turned out 950 cases (9,47%) were malignant. Out of 10,033 patients, 510 (5.08%) complained of nipple secretion. From 510 nipple secretions, 62 were nipple discharge (0.62%). Following the indication, 15 out of 62 cases were operated duct exploration with result 10 were malignant and 5 were benign. From the 15 cases which were operated and preceded by ultrasonography (USG), duct dilatation can be seen. From 10 nipple discharge with malignancy, 7 cases (70%) did not display any Ca suspicion in their mammography examination. Malignancy cases were found more in older age: 7 cases (70%) were above 50 years old. From these 10 cases with malignancy, only 1 case clinically had palpable mass. Pathology anatomy report revealed 10 cancer cases, 1,1% from 950 all cases who came to RSOS  from Januari 2007 until December 2010. 4 cases are insitu carcinoma, 1 nipple discharge with palpable mass, tumor was found 6x6x4 cm. There were 5 cases non cancer, 4 cases intraductal papilloma and 1 periductitis.
Case Report of Malignant Lymphoma of the Breast ASHARIATI, AMI; DJATMIKO, ARIO; ALI, ISKANDAR
Indonesian Journal of Cancer Vol 8, No 1 (2014): Jan - Mar 2014
Publisher : Indonesian Journal of Cancer

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Four cases of breast malignant lymphoma (BML) are discussed, diagnosed and managed. The issue of diagnosing BML, showed how different these 4 cases were, in particular in the imaging ultrasonography (USG). Generally, the USG of ductal carcinoma is irregular solid mass, while the USG of BML is compliant with cystic forms. Case 1 is 68 years old woman with left breast tumor. USG revealed hypoechoic lesion in the left breast with FNA result of malignant lymphoma, but still differential diagnosis with ductal carcinoma of the breast Mamma. Case 2 is a 52 years old woman who had left breast tumor. The USG revealed malignant lesion, left axilla node positive, although FNA result was ductal carcinoma, after simple mastectomy, the frozen section revealed malignant lymphoma. Case 3 is a 51 years old woman, USG of the left breast revealed malignant lesion, left axilla node positive, and excision biopsy revealed non-Hodgkins lymphoma diffuse large cell. Case 4 is a 51 years old woman, the USG revealed irregular hypoechoic lesions in both breasts and left supraclavicula node 5 mm. Core biopsy revealed bilateral breast non Hodgkins lymphoma subcutaneous, T-cell lymphoma. The therapeutic management of breast lymphoma is controversial and is not fully established yet. A strategy consisting of three cycles of CHOP followed by involved-field radiation therapy is reportedly superior to eight cycles of CHOP alone.
Histopathological Grading based on Tumor Margin according to BI-RADS Mammography in Breast Cancer Ayasha, Shabrinna; Mardiyana, Lies; Utomo, Budi; Ali, Iskandar
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 15 No. 2 (2024): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V15I22024.119-123

Abstract

Highlights: The highest distribution of breast cancer patients’ age based on the 5-year age interval was 45- 49 years old. There was no significant difference between tumor margin and age of breast cancer patients. There was no significant difference between tumor margin and histopathological grade.   Abstract Introduction: Mammography is an X-ray technique used to take images of the breast. It is the primary diagnostic method for breast tumors. Breast imaging reporting and data system (BI-RADS) classification is needed to determine benign or malignant masses by accessing the mass's shape, margin, density, and other features. However, the tumor margin is the most helpful one. This study aimed to know the difference in the distribution of tumor margin types in each histopathological grading in breast cancer patients. Methods: This was an observational analytic study with a comparative approach using secondary data from medical records of patients with breast cancer at the radio diagnostic and anatomical pathology installation of Dr. Soetomo General Academic Hospital, Surabaya, from January 2017 to December 2021. All statistical data were performed using the International Business Machines Corporation (IBM) Statistical Package for Social Sciences (SPSS) version 27, with a p<0.05 considered statistically significant. Results: Out of 235 cases, the highest distribution of breast cancer patients’ age interval was 45-49 years old (20.9%), the primary tumor margin type was spiculated (64.3%), and the highest distribution of histopathological grading was grade 3 (53.2%). There was no significant difference between tumor margin and age of breast cancer patients (p=0.815), with spiculated tumor margin as the most common type in all age intervals. There was no significant difference (p=0.163) in the distribution of tumor margin types in each histopathological grading, with spiculated tumor margin as the most common type in every grade. Conclusion: There was no significant difference between tumor margin and age of breast cancer patients, and there was no significant difference between tumor margin and histopathological grading.
Co-Authors Ami Ashariati ARIO DJATMIKO, ARIO Ayasha, Shabrinna Budi Utomo Lies Mardiyana, Lies WIWIEN RISTANTO, WIWIEN