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All Journal Jurnal Keperawatan Silampari PROFESSIONAL HEALTH JOURNAL PRIMER (Prima Medical Journal)
Yeni Puspawani
Universitas Prima Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Tingkatan Umur Terbanyak untuk Resiko Osteoporosis di Rumah Sakit Umum Royal Prima Medan Periode Tahun 2013 – 2016 Jenni Kristian Dachi; Adrian Khu; Edlin -; Yeni Puspawani; Juliana Lina; Hans Hotma Haposan Marpaung
PRIMER (Prima Medical Journal) Vol. 7 No. 1 (2022): Edisi April
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/pmj.v7i1.2792

Abstract

Osteoporosis adalah suatu penyakit yang ditandai dengan penurunan massa dan densitas tulang serta gangguan arsitektur tulang normal. Dengan berkurangnya kekuatan tulang, maka risiko terjadinya fraktur akan meningkat. World Health Organization (WHO) memasukkan osteoporosis dalam daftar 10 penyakit degeneratif utama di dunia. Tercatat bahwa terdapat kurang lebih 200 juta pasien di seluruh dunia yang menderita osteoporosis. Prevalensi osteoporosis di Indonesia sudah mencapai 19,7%. Usia memiliki peranan penting sebagai faktor resiko osteoporosis. Perhimpunan Osteoporosis Indonesia (Perosi) pada tahun 2007 melaporkan osteoporosis pada wanita usia di atas 50 tahun mencapai 32,3% dan pada pria di atas 50 tahun mencapai 28,8%. Penelitian ini merupakan penelitian deskriptif dengan desain potong lintang. Populasi penelitian adalah pasien rawat jalan di Rumah Sakit Umum Royal Prima Medan yang terdaftar sebagai pasien yang didiagnosis dengan osteoporosis. Sampel penelitian dipilih dengan menggunakan teknik total sampling yaitu sebanyak 50 kasus. Pengambilan data menggunakan rekam medis. Uji data yang digunakan adalah statistik deskriptif untuk menentukan distribusi frekuensi variabel penelitian. Dari penelitian ini diperoleh hasil bahwa perempuan menderita osteoporosis lebih tinggi dibandingkan laki-laki. Mereka dengan indeks massa tubuh berlebih/ overweight paling banyak mengalami osteoporosis. Penderita osteoporosis paling banyak memiliki riwayat fraktur. Usia 60-69 tahun merupakan kelompok usia dengan kejadian osteoporosis terbanyak. Penderita osteoporosis perempuan paling banyak pada kelompok usia 50-59 tahun. Penderita osteoporosis yang overweight paling banyak terdapat pada kelompok usia 60-69 tahun. Penderita osteoporosis dengan adanya riwayat fraktur paling banyak pada kelompok usia 50-59 tahun.
Uji Efektivitas Penurunan Kadar Kolesterol Total Ekstrak Etanol Kulit Batang Mangkokan Terhadap Tikus Jantan Putih Sri Lestari Ramadhani Nasution; Kenny Halim; Farhan Fachrizal; Yeni Puspawani
Jurnal Keperawatan Silampari Vol 6 No 1 (2022): Jurnal Keperawatan Silampari
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (259.942 KB) | DOI: 10.31539/jks.v6i1.4866

Abstract

Hypercholesterolemia is a condition in which cholesterol levels in the blood are more than normal. Europe and America are the regions with the highest hypercholesterolemia in the world with prevalence values ​​of 54% and 48%, respectively. Meanwhile, Africa and Southeast Asia are regions with the lowest prevalence of hypercholesterolemia with prevalence values ​​of 23% and 30%, respectively. In Indonesia, the age group of 25 - 34 years has the highest rank with high cholesterol levels. The purpose of this study was to determine the effect of lowering total cholesterol in male white rats (Rattus norvegicus) induced with Propylthiouracil (PTU). In this study, we used 25 rats which were divided into 5 groups equally. The groups were a negative control group (Na-CMC), a positive control group (Simvastatin), and three extract groups with doses of 500 mg/kgBW, 750 mg/kgBW, and 900 mg/kgBW. We made the ethanol extract of the bark of the Mangkokan stem by maceration. We induced all mice used in the study orally using a high-fat diet and PTU. In this study, the parameters that we studied were total cholesterol levels before induction, after induction, and after treatment. From this study, we found that all groups showed significant changes in total cholesterol levels (P value = 0.000). The group that was given ethanol extract at doses of 500 and 750 mg/kgBW showed a significant difference between the negative control group and the positive control group. Only the 900 mg/kgBW dose group showed no significant difference in total cholesterol levels with the positive control group. Thus, we can conclude that the ethanolic extract of the bark of the Mangkokan stem has the potential to reduce total cholesterol levels but is not as good as the positive control. Kata kunci : Kadar kolesterol total, Kulit batang mangkokan, PTU
Uji Efektivitas Ekstrak Umbi Bawang Putih (Allium Sativum l) terhadap Kadar Glukosa Darah Mencit (Mus Musculus) yang Diinduksi Aloksan Sri Lestari Ramadhani Nasution; Yeni Puspawani; Sintiya Hamdi; Kezia Debora
Jurnal Keperawatan Silampari Vol 6 No 1 (2022): Jurnal Keperawatan Silampari
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.776 KB) | DOI: 10.31539/jks.v6i1.4867

Abstract

This study aims to test the effectiveness of garlic bulbs on alloxan-induced blood glucose levels in mice. The method used is an actual experimental pretest-posttest control group design. The study revealed that garlic extract could reduce blood glucose levels in mice (p 0.05). The most doses of garlic extract that reduced blood glucose levels in diabetic mice were 6 mg/200 g BW and 12 mg/200 g BW. In conclusion, garlic extract significantly reduced blood glucose levels in diabetic mice when administered at 6 mg/200 g BW and 12 mg/200 g BW. Keywords: Allin, Allisin, Anti Diabetes, Garlic
Effect of Nanoemulsion Cream Containing Mangkokan Leaf Extract (Nothopanax scutellarium) on Incision Wound Healing and Malondialdehyde Levels in Streptozotocin-Induced Wistar Rats Diki Arya Nata Harahap; Najwa Maqhfirah; Yeni Puspawani; Sri Wahyuni Nasution
PROFESSIONAL HEALTH JOURNAL Vol. 8 No. 2 (2027)
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v8i2.1568

Abstract

Background: Background: Malondialdehyde (MDA) is a crucial biomarker for diabetes mellitus, which impedes wound healing through oxidative stress. Antioxidant flavonoids found in mangkokan leaves (Nothopanax scutellarium) have the capacity to heal wounds. The transdermal penetration of active ingredients is improved via nanoemulsion technology.Objective: To examine how mangkokan leaf extract-containing nanoemulsion cream affects MDA levels and wound healing in Wistar rats given streptozotocin. Methods: A true experimental study with pre-test post-test group design used 25 male Wistar rats divided into five groups (n=5): Normal, Negative Control, Positive Control (Metformin), Treatment I (10% nanoemulsion), and Treatment II (20% nanoemulsion). Phytochemical screening, blood glucose, wound healing (ImageJ), and MDA levels (ELISA) were assessed on days 0, 7, and 14.Results: Phytochemical analysis confirmed flavonoids, saponins, tannins, alkaloids, steroids, and glycosides. On day 14, Treatment II showed the lowest MDA level (6.12 ± 0.07 nmol/mL) and highest wound healing (95.9%), comparable to the positive control (p = 0.103; p = 0.468) and significantly better than the negative control (p < 0.001). A dose-response relationship was observed between 10% and 20% concentrations (p < 0.05).Conclusion: The 20% nanoemulsion cream effectively reduces oxidative stress and accelerates wound healing in diabetic rats through multi-target mechanisms, with efficacy comparable to standard therapy.
Co-Authors Adrian Khu Diki Arya Nata Harahap Edlin - Farhan Fachrizal Hans Hotma Haposan Marpaung Jenni Kristian Dachi Juliana Lina Kenny Halim Kezia Debora Najwa Maqhfirah Sintiya Hamdi Sri Lestari Ramadhani Nasution