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All Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Majalah Biomorfologi (Biomorphology Journal) Jurnal Forensik dan Medikolegal Indonesia
Nily Sulistyorini
Department Of Forensic Medicine And Medicolegal, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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EXPOSURE TO GOAT BILE FOR 28-DAYS CAUSES HEPATOCYTE INJURY: A HISTOPATHOLOGICAL STUDY Rizki Isnantono Prabowo; Nurina Hasanatuludhhiyah; Nily Sulistyorini; Kusuma Eko Purwantari
Majalah Biomorfologi Vol. 32 No. 2 (2022): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v32i2.2022.65-72

Abstract

Highlights: 1. Bile consumption, especially goat bile, is believed to have therapeutic effects even though it contains harmful ingredients that can cause toxic effects on the liver2. The administration of goat bile for 28 days had a toxic effect on the liver of the mice based on histopathological findings Abstract: Background: Bile consumption by Indonesians is believed to have therapeutic effects, especially goat bile. Goat bile is thought to contain harmful ingredients that can cause toxic effects on the liver. However, the 28-days oral toxicity study of goat bile has not been performed. Objective: To analyze the hepatotoxic effect of subchronic administration of goat bile on the liver of mice (Mus musculus). Material and Method: This was an experimental research with a post-test-only control group design. The samples used were 32 Balb/C mice (Mus musculus), which were grouped into 4 groups. The samples were administered with goat bile orally (3.2, 6.4, or 12.8 mL/kg/day) for 28 days. The liver was taken for histopathological examination and the hepatocytes injury score was performed. The scoring results were analyzed using Kruskal-Wallis, Mann-Whitney, and Spearman correlation tests (p<0.05). Result: Goat bile administration was associated with hepatocyte injury (p= 0.004). Groups with goat bile administration of 6.4 and 12.8 mL/kg/day had significant differences with the control group (p= .015 and .029 respectively) and the 3.2 mL/kg/day administered group (p= 0.006 and 0.009 respectively). Moreover, the increased administration of goat bile had a positive correlation with the level of hepatocyte injury (p= 0.004 and r_s= 0.504) Conclusion: Goat bile administration for 28 days had a significant toxic effect on the liver of mice at a dose of 6.4 mL/kg/day.
Trauma Profile of Homicide Victims at Dr. Soetomo General Academic Hospital, Surabaya, during the COVID-19 Pandemic Syarif, Ichsan; Yudianto, Ahmad; Saleh, Tania Ardiani; Sulistyorini, Nily
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 15 No. 1 (2024): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V15I12024.17-22

Abstract

Highlights: Most homicide victims were predominantly in the productive age range of 21-40 years old. Males were more likely to be homicide victims than females.   Abstract Introduction: The injuries of homicide victims are clues in forensic medicine to uncover a possible crime. In Indonesia, there are not many studies on trauma profiles, specifically in homicide cases. This study aimed to provide an overview of the trauma profile of homicide victims at Dr. Soetomo General Academic Hospital, Surabaya, from January 2020 until December 2021. Methods: This was a descriptive study. Secondary data was collected from 34 forensic examination reports at Dr. Soetomo General Academic Hospital, Surabaya. Data such as age, sex, type of injury, sites of injury, number of injuries, cause of death, and mechanism of death were analyzed statistically. Results: Most victims were between 21 and 30 years old and 31 and 40 years old (26.47%). Sex was dominated by men (76.47%). The most common type of injury was abrasion (25.71%). The most common injury sites were head-neck (34.34%) and chest-upper back (34.34%). The most common number of injuries was ≥10 (44.12%). The most common cause of death was sharp-force trauma (54.54%), and the most common mechanism of death was exsanguination (54.54%). Conclusion: Males predominated in the age ranges of 21 to 30 years old and 31 to 40 years old. The most common type of injury was abrasion. The most common sites of injury were the head, neck, and chest upper back. The most common number of injuries was ≥10. Most victims died of sharp-force trauma. Exsanguination was the most common mechanism of death.
LAPORAN KASUS KEMATIAN MENDADAK AKIBAT PANKREATITIS AKUT: JARANG TAPI MEMATIKAN Eko Dakholal Firdaus; Ahmad Yudianto; Soekry Erfan; Nily Sulistyorini
Jurnal Forensik dan Medikolegal Indonesia Vol 7 No 2 (2026): Jurnal Forensik dan Medikolegal Indonesia
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jfmi.2026.7.2.22143

Abstract

Pendahuluan: Kematian mendadak merupakan kejadian tidak terduga yang bersifat alamiah, dengan penyebab tersering adalah penyakit kardiovaskular. Meskipun pankreatitis akut jarang dilaporkan sebagai penyebab utama kematian mendadak, penyakit ini dapat memicu kondisi mematikan melalui mekanisme sistemik. Laporan Kasus: Seorang perempuan berusia antara 50-60 tahun ditemukan meninggal dunia di rumah kontrakannya setelah tercium bau tidak sedap. Jenazah memiliki riwayat Diabetes dan kolestrol tinggi namun tidak berobat teratur ke dokter dan hanya membeli obat di Apotek. Ditemukan obat metformin, acarbose, dan simvastatin di tempat kejadian. Pemeriksaan: Pemeriksaan luar menunjukkan tanda pembusukan, lebam mayat, sianosis pada bibir dan ujung jari, serta tidak ditemukan tanda kekerasan. Pemeriksaan dalam menunjukkan kongesti pembuluh darah di paru, lambung, dan usus, serta pankreas tampak kemerahan dengan berat 80 gram. Pemeriksaan histopatologi pankreas menunjukkan nekrosis luas disertai perdarahan tanpa tanda keganasan. Diskusi: Temuan klinis dan histopatologi mengarah pada pankreatitis akut yang memicu respon inflamasi sistemik (SIRS), menyebabkan gangguan fungsi multipel organ (MODS) termasuk asfiksia jaringan. Tidak ditemukan bukti adanya tanda-tanda kekerasan. Kesimpulan: Otopsi dilakukan untuk menentukan penyebab kematian. Dari hasil pemeriksaan dapat disimpulkan bahwa penyebab kematian dalam kasus ini adalah pankreatitis akut melalui mekanisme SIRS yang berujung pada kegagalan organ. Kasus ini menunjukkan bahwa pankreatitis akut, meskipun memiliki angka kejadian yang rendah, tetapi dapat menyebabkan kematian mendadak dan memerlukan pemeriksaan otopsi forensik untuk penegakan diagnosis.
Co-Authors Ahmad Yudianto Eko Dakholal Firdaus Kusuma Eko Purwantari Nurina Hasanatuludhhiyah Rizki Isnantono Prabowo Saleh, Tania Ardiani Soekry Erfan Syarif, Ichsan