Chronic Obstructive Pulmonary Disease (COPD) is a chronic lung disease characterized by limited air flow in the respiratory tract that is not fully reversible. This progressive disorder is caused by chronic inflammation due to gases that are toxic to the body. The main causes of COPD include cigarette smoke, air pollution from burning, and harmful gas particles. Several problems will arise resulting in respiratory failure which is defined as failure of ventilation and oxygenation failure caused by respiratory center disorders, chest wall muscle disorders and acute inflammation of lung tissue that causes shortness of breath. The general purpose of this study was to determine the Effect of Pursed Lips Breathing on the Breathing Pattern of Chronic Obstructive Pulmonary Disease Patients at Delia General Hospital, Kec. Done Kab. Langkat. The type of research used is a quasi-experimental (quasi-experimental) with a one group pretest-posttest design. This design also does not have a comparison group (control), but at least the first observation (pretest) has been carried out which allows testing the changes that occur after there is an experiment (program). In this study, parametric statistical tests were first carried out with the results meeting the assumption that the data were normally distributed, so that this study was analyzed using the paired t test using the degree of significance = 0.05. After the statistical test with the help of SPSS, the p value = 0.000 was obtained. The statistical test is said to be meaningful if the p value is below 0.05 < at the 95% confidence level. This study was analyzed using a paired t test using the degree of significance = 0.05. After the statistical test with the help of SPSS, the p value = 0.000 was obtained. Which means p value < (0.000 < 0.05), meaning H1 is accepted. Then it can be interpreted that there is a significant effect between Pursed Lips Breathing Exercise and breathing patterns in Chronic Obstructive Pulmonary Disease Patients. DF : degree of freedom, T : value T count, Sig,(2-tailed) : probability value/p value.