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All Journal Journal of Indonesian Medical Laboratory and Science (JoIMedLabS)
Febri Nur Ngazizah
D-III Analis Kesehatan, STIKes Borneo Cendekia Medika, Kalimantan Tengah, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology

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ANALISA EKSTRAK ETIL ASETAT AKAR KAIK-KAIK (Uncaira cordata (Lour.) Merr.) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus Reza Amelia; Riky; Febri Nur Ngazizah
Journal of Indonesian Medical Laboratory and Science Vol 2 No 1: April 2021
Publisher : Asosiasi Institusi Pendidikan Tinggi Teknologi Laboratorium Medik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53699/joimedlabs.v2i1.24

Abstract

The people of Kalimantan use many herbs for treating diseases, one of them is akar kaik-kaik (Uncaira cordata (Lour.) Merr.) The plant has a high concentration of alkaloids, phenolic, steroids, terpenoids, and flavonoids. that act as antibacterias using diffusion method so the Kirby Bauer/disk paper method used to define antibacterial activity marked the inhibition zone for S. aureus, which is a spherical positive Gram bacterium. U. cordata cordata was extracted through multilateral extraction by n-hexane solution followed by ethyl acetate. The extract used in this study was ethyl acetate with 5 variations of concentration treatment (100 mg/1, 200 mg/1, 300 mg/1, 400 mg/1, 500 mg/1). This research was an experiment design and analyzed by One Way ANOVA test, the mean score for inhibition zone for U. cordata ethyl ecetate extracts in 100 mg/L concentration was 12.7 mm under the weak category, for the concentration of 200 mg/L was 14.2 mm in the weak category, for the concentration of 300 mg/L was 15.3 mm in the weak category, for  the concentration of 400 mg/1 was 16.3 mm in the medium category and for the concentration of 500 mg/1 was 17.7 mm in the medium category.
UJI DAYA HAMBAT EKSTRAK BAWANG DAYAK (Eleutherine palmifolia (L.) Merr.) TERHADAP BAKTERI Salmonella parayphi Nor Aini Aida; Febri Nur Ngazizah; Miftachul Sobirin; Riky Riky
Journal of Indonesian Medical Laboratory and Science Vol 2 No 2: Oktober 2021
Publisher : Asosiasi Institusi Pendidikan Tinggi Teknologi Laboratorium Medik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53699/joimedlabs.v2i2.48

Abstract

Dayak onions (Eleutherine palmifolia (L.) Merr.) Is one of the natural ingredients which is often used for medicine in Kalimantan. E.  palmifolia used for treatment because it contains secondary metabolite compounds that have potential as antibacterial. Such as phenolic compounds, flavonoids, alkaloids, saponins, tannins and glycosides which are included in polar compounds. This study aims to determine the effect of ethanol extract 70% E. palmifolia against bacteria Salmonella paratyphi with the extraction method maceration. S. paratyphi is a bacterial pathogen against humans whose habitat is in the digestive tract. This research was conducted to test the extract's antibacterial activity with gradient concentration of 20 mg / mL, 30 mg / mL, 40 mg / mL, 50 mg / mL, and 60 mg / mL and chloramphenicol as a positive control and sterile aquadest as a negative control.  The antibacterial test method used is diffusion method with 5 repetitions. Our results showed that E. palmifolia extract could inhibit S. paratyphi growth as evidenced by the presence of an inhibition zone that is formed around paper disk on media with concentration 20 mg / mL, 30 mg / mL, 40 mg / mL, 50 mg / mL, and 60 mg / mL. Where the average diameter of the inhibition zone was 6.6 mm, 7.4 mm, 8.8 mm, 9.9 mm, respectively fall into the category of ineffective inhibition and 11 mm is in the weak category. Based on the research that has been done, it was found that there was an effect of giving E. palmifolia extract on the growth of S. paratyphi bacteria but there was no significant difference based on the one way ANOVA test.
ANALISA EKSTRAK ETANOL DAUN BAJAKAH KAIT-KAIT (Uncaria acida (Hunt.) Roxb.) TERHADAP BAKTERI Escherichia coli MENGGUNAKAN METODE KIRBY BAUER Mia Irawan; Febri Nur Ngazizah; Riky Riky; Iqlila Romaidha
Journal of Indonesian Medical Laboratory and Science Vol 2 No 2: Oktober 2021
Publisher : Asosiasi Institusi Pendidikan Tinggi Teknologi Laboratorium Medik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53699/joimedlabs.v2i2.49

Abstract

Kalimantan forest is the largest tropical rain forest which is one of the places with biodiversity that has the potential for development in the field of health or medicine, one of the plants used for treatment is hook root (Uncaria acida (Hunt.) Roxb.). This plant has indole alkaloid compounds, triterpenes, flavonoids and phenylpropanoids that act as antibacterial. In this study, an antibacterial test was conducted using the Kirby Bauer method to determine the antibacterial activity which was characterized by the formation of an inhibition zone around the paper disc. The bacteria tested were E. coli. The extract tested in this study was the ethanolic extract of U. acida leaves with 5 concentrations of treatment (5 mg/mL, 15 mg/mL, 30 mg/mL, 40 mg/mL and 50 mg/mL). The average result of the inhibition zone of the ethanolic extract of U. acida leaves in a concentration of 5 mg/mL is 8.1 mm in the weak category, the concentration of 15 mg/mL is 8.3 mm in the weak category, the concentration of 30 mg/mL is 9.1 mm in the weak category, 40 mg/mL ie 9.2 mm in the weak category and 50 mg/mL in the moderate category. Using significance (? > 0.05) which means that the inhibition zone data on the growth test of E. coli bacteria at the 5 concentrations affected the inhibition zone of E. coli bacteria.
PERBANDINGAN EFEKTIVITAS EKSTRAK BAWANG PUTIH (Allium sativum L.) DENGAN DAUN BAJAKAH (Uncaria acida Roxb.) SEBAGAI LARVASIDA VEKTOR DENGUE Aedes aegypti Fitra Akbar Mulyono; Iqlila Romaidha; Nur Aini Hidayah Khasanah; Febri Nur Ngazizah
Journal of Indonesian Medical Laboratory and Science Vol 2 No 2: Oktober 2021
Publisher : Asosiasi Institusi Pendidikan Tinggi Teknologi Laboratorium Medik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53699/joimedlabs.v2i2.50

Abstract

Dengue fever is a disease caused by the dengue virus carried by the A. aegypti mosquito. Making natural larvicides from plants such as Alium sativum L. and Uncaria acida Roxb. are indispensable. This study aims to make natural larvicides from A. sativum and U. acida. This study is an experimental study using a Completely Randomized Design (CRD) to see the effectiveness of the extract A. sativum with U. acida as larvicide of the mosquito A. aegypti.This study used 20 mosquito larvae for each concentration and repeated 4 times. The results showed that the larvicide of A. sativum at the highest concentration reached 100% mortality, while the larvicide of U. acida at the highest concentration reaching 80% mosquito larvae death A. aegypti. Analysis of research data was processed using SPSS version 20. One Way Anova analysis of A. sativum extract was sig 0.049 and U. acida extract was sig 0.245. In the extract of A. sativum there was a significant difference in the mortality of mosquito larvae at each concentration, while in the extract of U. acida there was no significant difference in the mortality of mosquito larvae at each concentration. T-test analysis of the extracts of A. sativum and U. acida was sig 0.80, so there was no difference in effectiveness between the two larvicidal extracts. It can be concluded that the larvicidal research results of A. sativum extract and U. acida extract were equally effective on A. aegypti larvae.
Co-Authors Fitra Akbar Mulyono Iqlila Romaidha Mia Irawan Miftachul Sobirin Nor Aini Aida Nur Aini Hidayah Khasanah Reza Amelia Riky Riky Riky