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All Journal AloHA International Journal of Health Advancement (AIJHA)
Iwan Iskandar
Department of Environmental Health, Potekkes Kemenkes Tanjungpinang
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Mutations in the p53 Gene in Colorectal Cancer Hevi Horiza; Iwan Iskandar; Mutia Yuhesti
Aloha International Journal of Health Advancement (AIJHA) Vol 5, No 8 (2022): August
Publisher : Alliance oh Health Activists (AloHA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/aijha50801

Abstract

Colorectal cancer is the second leading cause of death, which can be caused by diet, lifestyle, the presence of genes that play a role in the cell cycle and its relationship to the cancer growth process, such as groups that trigger tumors (tumor oncogenes) such as race genes and tumor suppressor such as the p53 gene. One of the causes of colorectal cancer is mutation and allelic loss of the p53 gene. Mutations in the p53 gene mostly occur in conserved areas, namely in the exon 5-9 region, and there are also found in areas outside the exon 5-9 region. Efforts to treat and prevent colorectal cancer are chemotherapy and improving diet by consuming fiber-rich foods. Keywords: colon; colorectal cancer; p53 gene mutation; treatment
Characterization of Green Betel Leaf Extract (Piper bettle L) as Raw Material for Mouthwash Preparations Iwan Iskandar; Hevi Horiza; Mutia Yuhesti
Aloha International Journal of Health Advancement (AIJHA) Vol 5, No 8 (2022): August
Publisher : Alliance oh Health Activists (AloHA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/aijha50803

Abstract

Previous research reported that the phenol coefficient of a sample of betel leaf decoction disinfectant was only 0.3-0.5 ppm, because this compound evaporates easily with heat treatment. Therefore, in this research, a viscous extract from green betel leaves was carried out. Thus, it is necessary to characterize the condensed extract of green betel leaves from Kijang, Bintan Regency, Indonesia, which is used in the manufacture of mouthwash preparations. Based on the results of qualitative tests, the thick extract of green betel leaves contains tannins, saponins and flavonoids. Based on quantitative tests, it was found that the thick betel leaf extract contained 61.9032 ppm of antioxidants, 524.8148 ppm of flavonoids (0.53%), 219.44 ppm of tannins (0.22%), 3213.33 ppm of total phenols (3 .21%) and saponins 2542.22 ppm (2.54%) from 100 g sample. The content of these compounds can be used as part of herbal mouthwash formulas. Keywords: green betel leaf; extract; mouthwash
Co-Authors Hevi Horiza Mutia Yuhesti