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John Akpan Udobang
University of Uyo
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Antioxidative Stress and Hepatoprotective Activities of Leaf Extract and Fractions of Setaria megaphylla in Plasmodium berghei Infected Mice Ndanti Bartholomew William; Augustine Lawrence Bassey; John Akpan Udobang; Jude Efiom Okokon
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.25-32

Abstract

Setaria megaphylla (Steud) Dur & Schinz (Poaceae), a perennial grass used traditionally in the treatment of various diseases such as malaria was, investigated for antioxidative stress activity in Plasmodium berghei-infected mice. The leaf extract (200-600 mg/kg) and fractions (hexane, dichloromethane, ethyl acetate and methanol; 400 mg/kg) of S. megaphylla were investigated for antioxidative stress and hepatoprotective activities in Plasmodium berghei-infected mice using a modified suppressive test model. Antioxidative stress and hepatoprotective potentials were assessed by determining oxidative stress markers levels, liver function indices and histopathology of liver. The extract/fractions progressively reduced parasitaemia induced by chloroquine-sensitive P. berghei infection with the methanol fraction exerting the highest activity. The leaf extract and fractions caused significant (p<0.05 0.001) increases in the levels of oxidative stress markers enzymes and molecules (SOD, CAT, GPx, GSH) and also reduced MDA level significantly (p<0.05) in the livers of the treated-infected mice. The extract/fractions treatment caused reduction in liver enzymes (ALT, AST and ALP), total and conjugated bilirubin. Histology of livers revealed absence or significant reductions in pathological features in the treated infected mice compared to untreated infected mice. The leaf of S. megaphylla may possess antioxidative stress and hepatoprotective effects which may in part be mediated through the chemical constituents of the plant.
Solanum anomalum Leaf Extract and Fractions Attenuate Oxidative Stress and Liver Injuries in Alloxan-Induced Diabetic Rats Idongesit Charles Etuk; John Akpan Udobang; Nwakaego Omonigho Ebong; Jude Efiom Okokon
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.33-44

Abstract

The leaf of Solanum anomalum used in ethnomedicine for the treatment of various ailments such as diabetes was evaluated for antioxidative stress and hepatoprotective potentials against hepatic injuries in alloxan-induced diabetic rats. Antioxidative stress and hepatoprotective activities of leaf extract and fractions (70-210 mg/kg) were assessed by determining oxidative stress markers levels, liver function indices and histopathological study of livers of treated rats. The leaf extract and fractions caused significant (p<0.05 0.001) increases in the levels of oxidative stress markers (SOD, CAT, GPx, GSH) in the livers of the treated diabetic rats. The extract/fractions treatment caused reduction in liver enzymes (ALT, AST and ALP), total and direct bilirubin. Histology of the livers revealed absence or significant reductions in pathological features in the treated diabetic rats compared to untreated diabetic rats. The results show that the leaf extract and fractions of S. anomalum has antioxidative stress and hepatoprotective potentials which may be due to the antioxidant activities of their phytochemical constituents.
In-Vivo Alpha-Amylase and Alpha-Glucosidase Inhibitory Activities of Solanum anomalum Leaf Extract and Fractions Jude Efiom Okokon; Idongesit Charles Etuk; John Akpan Udobang; Nwakaego Omonigho Ebong
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.127-132

Abstract

Solanum anomalum Thonn. ex Schumach. (family Solanaceae), an edible shrub whose fruits and leaves are used medicinally to treat diseases including diabetes was evaluated for effect on alpha amylase and alpha glucosidase enzymes in vivo. The leaf extract (70-210 mg/kg) and fractions (hexane, dichloromethane, ethyl acetate, methanol, 140 mg/kg) of S. anomalum were evaluated in vivo for inhibitory effect on alpha amylase and alpha glucosidase enzymes using starch, sucrose and maltose as substrates. Acarbose was used as reference drug. The leaf extract especially middle dose (140 mg/kg) and fractions (ethyl acetate and hexane) caused significant (p<0.05) reduction in blood glucose levels of treated with the various substrates used. Ethyl acetate fraction exerted the highest inhibitory effect when starch and maltose were used as substrates followed by n-hexane and methanol. n-Hexane was the most active fraction followed by ethyl acetate when sucrose was used as substrate. The results suggest that the leaf extract and fractions of S. anomalum have the potentials to inhibit alpha amylase and glucosidase in rats.
Co-Authors Augustine Lawrence Bassey Idongesit Charles Etuk Jude Efiom Okokon Ndanti Bartholomew William Nwakaego Omonigho Ebong