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EFEKTIVITAS ANTIBIOTIK PADA PASIEN PNEUMONIA COVID-19 : STUDI OBSERVASIONAL Farid Zulkarnain Nur Syah; Abdul Rahem; Anita Purnamayanti; Rella Indah Karunia
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.878

COVID-19 has become a deadly pandemic worldwide. The use of empiric antibiotics in cases of COVID-19 pneumonia has the risk of triggering bacterial resistance. The purpose of the study was to analyze the use of antibiotics used in cases of COVID-19 pneumonia. The design of the study was an observational study conducted retrospectively from June 2021 to August 2021. The subjects of the study were patients with confirmed COVID-19 pneumonia, as diagnosed by the doctor based on the results of a chest CT scan and PCR. The total number of research subjects was 111. The antibiotics used were azithromycin (n = 42) and levofloxacin (n = 69). There was no significant difference between the initial clinical condition of hospital admission in subjects receiving azithromycin and subjects receiving levofloxacin (p=0.098) based on the WHO clinical progression scale score. There was a significant difference between azithromycin and levofloxacin for the length of therapy (p = 0.000) and length of hospitalization (p = 0.004). There was a significant difference (p = 0.006) in clinical conditions based on WHO clinical progression scale scores before and after using azithromycin. There was no significant difference (p = 0.114) in clinical conditions before and after using levofloxacin. There was no significant difference in mortality (p = 0.275) between the two types of antibiotics. Subject mortality was not affected by gender, advanced age (> 65 years), and comorbid disease. Azithromycin is more effective in improving the clinical condition of patients with COVID-19 pneumonia compared to levofloxacin.

EFEKTIVITAS ANTIBIOTIK PADA PASIEN PNEUMONIA COVID-19 : STUDI OBSERVASIONAL Farid Zulkarnain Nur Syah; Abdul Rahem; Anita Purnamayanti; Rella Indah Karunia
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.878

COVID-19 has become a deadly pandemic worldwide. The use of empiric antibiotics in cases of COVID-19 pneumonia has the risk of triggering bacterial resistance. The purpose of the study was to analyze the use of antibiotics used in cases of COVID-19 pneumonia. The design of the study was an observational study conducted retrospectively from June 2021 to August 2021. The subjects of the study were patients with confirmed COVID-19 pneumonia, as diagnosed by the doctor based on the results of a chest CT scan and PCR. The total number of research subjects was 111. The antibiotics used were azithromycin (n = 42) and levofloxacin (n = 69). There was no significant difference between the initial clinical condition of hospital admission in subjects receiving azithromycin and subjects receiving levofloxacin (p=0.098) based on the WHO clinical progression scale score. There was a significant difference between azithromycin and levofloxacin for the length of therapy (p = 0.000) and length of hospitalization (p = 0.004). There was a significant difference (p = 0.006) in clinical conditions based on WHO clinical progression scale scores before and after using azithromycin. There was no significant difference (p = 0.114) in clinical conditions before and after using levofloxacin. There was no significant difference in mortality (p = 0.275) between the two types of antibiotics. Subject mortality was not affected by gender, advanced age (> 65 years), and comorbid disease. Azithromycin is more effective in improving the clinical condition of patients with COVID-19 pneumonia compared to levofloxacin.

KEPATUHAN PENGGUNAAN OBAT ORAL ANTI-DIABETES PADA PASIEN DIABETES MELITUS TIPE-2 DI PUSKESMAS WILAYAH KOTA MALANG DENGAN MODEL THE MEDICATION ADHERENCE REPORT SCALE-5 syah, farid zulkarnain nur; Adawiyah, Robiatul
SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Vol. 4 No. 1 (2025): SITAWA : Jurnal Farmasi Sains dan Obat Tradisional
Publisher : LPPM Akademi Farmasi Imam Bonjol Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62018/sitawa.v4i1.111

Pasien Diabetes Melitus Tipe-2 (DMT2) mendapatkan terapi Oral Antidiabetes (OAD) monoterapi atau kombinasi. Semakin banyak jenis obat dan frekuensi obat yang diminum mempengaruhi kepatuhan pasien untuk minum obatnya. Kepatuhan minum obat pasien DM masih menjadi masalah serius di seluruh dunia. Penelitian ini bertujuan untuk mengetahui kepatuhan minum OAD pada pasien DMT2 di salah satu puskesmas di Kota Malang. Metode yang digunakan adalah penelitian deskriptif observasional dengan desain cross-sectional. Sampel penelitian berjumlah 55 pasien yang diambil dengan teknik purposive sampling, dengan kriteria inklusi pasien DMT2 dengan atau tanpa komorbid, yang mendapatkan terapi OAD. Kriteria eksklusi adalah pasien yang sedang hamil atau mengalami stroke. Instrumen yang digunakan adalah kuesioner The Medication Adherence Report Scale-5 (MARS-5). Hasil penelitian menunjukkan bahwa mayoritas pasien berusia ≥ 60 tahun (71%), memiliki pendidikan terakhir sekolah dasar (76,4%), dan sebagian besar tidak bekerja (91%). Komorbid yang paling sering ditemukan adalah hipertensi (53%). Terapi OAD yang paling banyak diresepkan adalah kombinasi glimepirid dan metformin (41,8%). Hasil penelitian ini menunjukkan bahwa Kepatuhan terhadap penggunaan obat oral antidiabetes pada pasien diabetes melitus tipe-2 di Puskesmas wilayah Kota Malang, kategori kepatuhan tinggi, yaitu sebesar 56,4%.

Gambaran Peresepan Antibiotik di Poli Telinga Hidung Tenggorokan (THT) di Rumah Sakit X Kabupaten Situbondo Nanda, Solikhati Ika; Syah, Farid Zulkarnain Nur
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 4 No 2 (2025): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v4i2.70

Antibiotics are chemical compounds used to treat bacterial infections by inhibiting the growth or killing bacteria. Antibiotics are classified as prescription medications, meaning their use must be based on a doctor's recommendation and prescription. The selection of antibiotics should be based on information about the spectrum of microorganisms causing the infection, microbiological test results, pharmacokinetic and pharmacodynamic profiles of the antibiotics, as well as their affordability. The prescribing of antibiotics in hospitals, both in terms of the types of antibiotics used and the medical reasons for their use, may vary depending on the guidelines for antibiotic use at each hospital. This study aims to provide an overview of antibiotic prescribing in the Ear, Nose, and Throat (ENT) clinic at Situbondo District Hospital. The research design is descriptive observational. The samples used were all doctor prescriptions from the ENT clinic at the hospital, filled at the outpatient pharmacy depot during November 2023. The sampling technique employed was total sampling, resulting in 110 prescriptions. The findings showed that the most commonly prescribed antibiotics were Co-Amoxiclav (66.2%), Cefixime (20.0%), Levofloxacin (7.6%), Azithromycin (4.1%), and a combination of Polymyxin B Sulfate and Neomycin Sulfate (2.1%). Regarding the duration of antibiotic therapy, oral antibiotics were prescribed for 2 to 7 days, while ear drops were used for 20 to 27 days.

Differences in Length of Hospital Stay for COVID-19 Patients Given Combination Supplementation of Vitamins C, D, and Zinc: A Clinical Nutrition Perspective: Perbedaan Lama Waktu Rawat Inap Pasien Covid 19 yang Diberi Suplementasi Kombinasi Vitamin C, D, dan Zink: Tinjauan Aspek Gizi Klinis Syah, Farid Zulkarnain Nur; Fidyasari, Ambar
jurnal makanan tropis dan teknologi agroindustri Vol 6 No 02 (2025): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/jtfat.v6i02.1656

COVID-19 has placed a substantial burden on global healthcare systems. Nutritional improvement through dietary supplementation with vitamin C, vitamin D, and zinc plays a critical role in supporting the immune system. This study aimed to evaluate the effect of combined supplementation with vitamins C, D, and zinc on the length of hospital stay in COVID-19 patients. This study employed a retrospective observational design conducted in a hospital setting. A total of 81 patient were included as research subjects. The majority of patients were aged 50–64 years (45.7%) and female (51.9%). Data were analyzed using the Kruskal–Wallis test, followed by post hoc analysis. The results showed that the group receiving the combined supplementation of vitamins C, D, and zinc had the shortest average hospital stay (10.00 ± 4.299 days), compared to the vitamin D group (12.29 ± 4.165 days) and the vitamin C and D group (12.69 ± 2.869 days), with a statistically significant difference (95% CI; p = 0.004). This study concludes that the combination of the three micronutrients (vitamins C, D, and zinc) significantly reduces the duration of hospitalization in COVID-19 patients compared to those receiving vitamin D alone or a combination of vitamins C and D.

Optimasi Formulasi, Stabilitas Fisik dan Uji Iritasi Lotion Tabir Surya Kombinasi Benzophenone-4 dan Octocrylene Najih, Yuli Ainun; Nailufa, Yuyun; Rakhma, Dita Nurlita; Azhanzi, Davan Ercha Wafi; Syah, Farid Zulkarnain Nur
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.153

Ultraviolet (UV) radiation exposure necessitates the creation of sunscreen formulas that are stable, safe for the skin, and photoprotective. Although benzophenone-4 (BZP-4) and octocrylene (OCT) are widely used as chemical UV filters, studies on the physical stability and irritation of optimizing the combination of the two in lotion formulations are still limited. The purpose of this study is to improve the physical stability, formulation, and irritation testing of a sunscreen lotion that combines BZP-4 and OCT. Variations in single and combination concentrations (1–5%) were included into five formulations. Organoleptic testing, pH, viscosity, spreadability, adhesion, emulsion type, physical stability using centrifugation and six cycles of testing, and irritation testing based on a non-animal alternative method using the Hen's Egg Test–Chorioallantoic Membrane (HET-CAM) were all used to evaluate the preparations. A paired t-test was used for statistical analysis to compare parameters prior to and during the physical stability test. The combination formula of 1% BZP and 1% OCT produced the best physical properties (pH 6.44; viscosity 2793 cP), was stable in centrifugation and cycle tests (p>0.05), and did not irritate the skin (HET-CAM score 0.98±0.04). Conversely, single formulas and high concentrations showed moderate to strong irritation. The results of this study contribute scientifically to the conclusion that the combination lotion formulation of BZP-4 1% and OCT 1% has good physical stability and does not cause irritation.

Evaluasi Digital Adherence Technology Berbasis Kode QR (Q-Monte) untuk Pemantauan Kepatuhan Pengobatan Tuberkulosis Syah, Farid Zulkarnain Nur; Susanto, Noor Annisa; Zainuri, Akhmad
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 2 (2026): Oktober - Maret
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i2.160

Tuberculosis (TB) treatment adherence is a critical determinant of therapeutic success; however, monitoring adherence remains challenging in primary healthcare settings. Digital adherence technology (DAT) offers an alternative approach to monitor patient adherence more efficiently. This study aimed to evaluate the initial feasibility of implementing a QR code–based DAT system (Q-Monte) for monitoring TB treatment adherence in primary healthcare centers. This study employed a pilot feasibility design with a prospective observational approach involving 30 outpatient TB patients from two primary healthcare centers in Malang Regency. Participants were recruited using purposive sampling with the following inclusion criteria: TB patients aged ≥12 years, receiving oral anti-tuberculosis therapy, owning an Android-based smartphone and an active WhatsApp number, and being willing to be monitored for 30 days. Patients with HIV co-infection or multidrug-resistant TB (TB-MDR), those who transferred healthcare facilities during the observation period, or those with stroke comorbidity were excluded. Most participants were male (56.7%), aged 45–54 years (30.0%), had completed senior high school education (50.0%), and had no comorbidities (80.0%). Adherence was measured as the percentage of days with QR code scanning, while system usability was assessed using the System Usability Scale (SUS). The results showed an average QR code scanning adherence rate of 90.3% over 30 days, with 46.7% of patients reporting having taken medication without performing the QR code scan. The usability evaluation yielded a mean SUS score of 75.7 (grade B). These findings indicate that Q-Monte is feasible as a tool for monitoring TB treatment adherence in primary healthcare settings, although further optimization of technical support and user education is needed to improve the reliability of digital adherence recording.

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