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Analisis Efektivitas Pengikat Fosfat Tablet Kalsium Karbonat yang Dikunyah Dibandingkan yang Ditelan Utuh pada Pasien Penyakit Ginjal Kronis Dengan atau Tanpa Gangguan Saluran Cerna Prawesti, Galuh Nawang; Yogiantoro, R. Moh.; Widodo, Gunawan; Purnamayanti, Anita
Jurnal Farmasi Sains dan Terapan Vol 6, No 1 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2540.23 KB) | DOI: 10.33508/jfst.v6i1.2009

Abstract

Chronic Kidney Disease (CKD) patient with Mineral and Bone Disorder complication have to chew calcium carbonate tablet as a phosphate binder, but infact, patient swallow it in a whole. Gastrointestinal (GI) disorders can affect the efficacy of medicine. This study aims to analyze the effectiveness comparation of chewed and whole swallowed calcium carbonate tablet in CKD patients with or without gastrointestinal disorders. This prospective quasi experimental study with non-inferiority design was conducted on May 28th to August 22nd 2012, with 22 sample (stage 3-5 CKD), 14 men, 8 women, divided into 4 groups (1st: patients with GI disorder and whole swallowed calcium carbonate, 2nd: with GI disorders and chewed tablet, 3rd: without GI disorders and whole swallowed tablet, 4th group: without GI disorders and chewed tablet, all tablet are used with meal). Before and after the 6th week research period, calcium and phosphate blood levels measurements had been taken, adherence had been measured every two weeks using the Morisky questionnaire and pill count. The results showed that there was no significant difference in the increased of calcium levels, except for group 1 compared to group 3 (p = 0.027), the decreased phosphate levels (p = 0.724; 0.089; 0.089; 0.414; 0.569; 1.000) and the value of the product calcium-phosphate (p = 1.000; 0.308; 0.186; 0.414; 0.425; 0.728). The conclusion is that the way to use the medicine and the states of gastrointestinal disorders did not significantly influence the effectiveness of calcium carbonate tablet.
HUBUNGAN PENGETAHUAN DAN PERILAKU DALAM MEMPEROLEH ANTIBIOTIK SECARA PER ORAL DI BEBERAPA APOTEK DI SURABAYA I Wayan L.D. Purnamahardika; Anita Purnamayanti
CALYPTRA Vol. 7 No. 2 (2019): Calyptra : Jurnal Ilmiah Mahasiswa Universitas Surabaya (Maret)
Publisher : Perpustakaan Universitas Surabaya

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Abstract

Abstract – According to Yusuf Sholihan (2015) in Surakarta city as much as 64,86% of respondents had bought antibiotics without prescriptions respondents with poor knowledge of antibiotics were 36,96%. Antibiotic resistance is currently the greatest threat to global public health. This study aimed to analyze the correlation between knowledge and behavior of the respondents in seeking antibiotics at several pharmacies Surabaya. This was a cross sectional research using questionnaire to analyze respondents knowledge of antibiotics and checklistto analyze antibiotics seeking behavior. The results of this study indicated most of the respondents were at good level of knowledge ( 42.31%); while respondents with poor level of knowledge were 21.15%. All the respondents received the prescribed antibiotics, indicating that the antibiotic seeking behavior were correct, the correlation analysis between level of knowledge and antibiotics seeking behaviour using spss could not be performed, because there was no variation in behavior. Based on the percentage of the highest level of knowledge, it had been concluded that there was correlation between the level of knowledge with antibiotics seeking behavior.
HUBUNGAN KARAKTERISTIK FARMAKOKINETIKA DENGAN RESPON TERAPI PADA KASUS KEGAWAT-DARURATAN PASIEN ANAK Jamilah Jamilah; Anita Purnamayanti
CALYPTRA Vol. 7 No. 2 (2019): Calyptra : Jurnal Ilmiah Mahasiswa Universitas Surabaya (Maret)
Publisher : Perpustakaan Universitas Surabaya

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Abstract

This study was aimed to find out the correlation between the characteristics of intravenous aminophylline pharmacokinetics with therapeutic response in pediatric patients with severe asthma attack and / stop breathing threat. The research design is retrospectively based on medical record at IGD RSU Haji Surabaya. Of the 36 patients receiving intravenous aminophylline from January 2016-June 2017 we obtained an estimate of pharmacokinetic parameters using population data assumption and PKPD data analysis with monolix® program obtained Vd = 0.286 liter / kg, K = 0.00564 / h, K12 = 2.41 / h , K21 = 0.0697 / h, Emax = 4.7 mg / L, and EC50 = 1.66mg / L. It was concluded that there was a relationship (p = 0,000) between the pharmacokinetics characteristics of aminophylline of intravenous infusion with therapeutic response in pediatric with severe asthma attack.
KESESUAIAN PENGGUNAAN ANTIBOTIKA PADA SECTIO CAESAREAN (SC) DENGAN PETA KUMAN DI RSI SITI HAJAR SIDOARJO Suti Aminah; Abdul Rahem; Anita Purnamayanti
CALYPTRA Vol. 6 No. 1 (2017): Calyptra : Jurnal Ilmiah Mahasiswa Universitas Surabaya (September)
Publisher : Perpustakaan Universitas Surabaya

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Abstract

Kultur kuman pada penyakit yang berpotensi infeksi di RS Islam (RSI) Siti Hajar belum dilakukan. Pemberian antibiotika perioperatif pada tindakan Seclio Caesarean (SC) selalu dilakukan, padahal tidak terdapat data kepekaan kuman terhadap antibiotik. Penelitian ini bertujuan untuk mengetahui kesesuaian penggunaan antibiotika pada pasien yang menjalani tindakan pembedahan pada .. Sectio Caesarean (SC) terhadap peta kuman hasil pemeriksaan swab di RSJ Siti Hajar dan terhadap pustaka. Rancangan penelitian ini adalah non- eksperimental, dengan arah pengambilan data secara prospektif. Adapun bahan penelitian ini adalah data rekam medik pasien yang menjalani tindakan Sectio Caesarean (SC), data identifikasi kuman hasil pemeriksaan swab pada AC dan lantai di ruang perawatan pasca operasi, catatan pemberian obat dari perawat dan peta kuman hasil uji kultur beberapa spesimen pasien di RSI Siti Hajar pada bulan Januari sampai Juni 20 15. Pada tahap pertama dilakukan pendokumentasian data rekam medik pasien terhadap penggunaan antibiotika yang sesuai dengan peta kuman di RSJ Siti Hajar. Tahap kedua dilakukan pencatatan pemberian antibiotika kepada pasien dengan melihat catatan pengobatan perawat, melakukan interview kepada pasien, observasi langsung dan meminta informed concent. Dikatakan sesuai apabila antibiotika yang digunakan sesuai dengan hasil uji peta kuman dan pustaka yang ada. Penelitian ini menunjukkan bahwa kesesuaian penggunaan antibiotika pada pasien dengan pembedahan pada persalianan atau Sectio Caesarean (SC) di RSI Siti Hajar pada Bulan Januari 2015 sampai dengan Bulan Maret 2015 dihasilkan data "Tidak Sesuai" (100%), dan antibiotika yang dipakai adalah Cefotaxim, Ceftriaxon dan Ceftazidim yang resisten terhadap kuman Klebsiella Ozaenae, Acinetobactaer spp,Pseudomonas spp, Klebsiella Pneumonia. Kata kunci: antibiotika perioperatif, sectio caesarena, peta kuman
PERBANDINGAN EFEKTIVITAS METHOTREXATE DENGAN PENGGANTI METHOTREXATE PADA PASIEN RHEUMATOID ARTHRITIS ( Studi Pada Pasien Rawat Jalan di RSUD Ulin Banjarmasin) Arlina Fauziah; Abdul Rahem; Anita Purnamayanti
CALYPTRA Vol. 7 No. 2 (2019): Calyptra : Jurnal Ilmiah Mahasiswa Universitas Surabaya (Maret)
Publisher : Perpustakaan Universitas Surabaya

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Abstract

Background :The occurrence of Methotrexate drug shortage at Ulin Banjarmasin Regional Hospital caused a change of Rheumatoid Arthriris (RA) therapy in outpatients, which was originally used Methotrexate turned into using Leflunomide (Arava) and later on Azatioprine (Imuran). It was necessary to analyze the efficacy between Methotrexate with Methotrexate replacement therapy. Method : Design of the study was anobservational research with retrospective retrieval data.Data analysis using One Way Anova and paired t test. The efficacy of patient therapy RA analyzed from the Disease Activity Score 28 (DAS28) and efficacy persentage. Result :The results of One Way Anova analysis showed no significant difference between all treatment groups (P> 0.05). From a Post Hoc LSD test it was found that there were significant differences between the initial DAS28Methotrexate with the final DAS28Imuran (P = 0.0034), and between the final DAS28 Arava with the final DAS28 Imuran (P = 0.049). And in the Paired t test there were significant on mean differences between the initial and final DAS28Methotrexate, the initial and final DAS28Arava, and the initial and final DAS28Imuran. Conclusion : There was a difference in the efficacy of Methotrexate with Arava and Imuran with Arava but there was no differences in the efficacy of Methorexate with Imuran in outpatient RA patients in RSUD Ulin Banjarmasin
PENGARUH PENAMBAHAN PROBIOTIK TERHADAP EFEK ANTIMIKROBA TERAPI VAGINOSIS BAKTERIAL DENGAN METRONIDAZOLE TABLET (Studi Probiotik L. rhamnosus 2.5 x 109 CFU, L. reuteri 2.5 x 109 CFU pada wanita yang tidak hamil di RSIA Kendangsari Surabaya) Vina Martasaphira; Budi Santoso; Anita Purnamayanti
CALYPTRA Vol. 8 No. 1 (2019): Calyptra : Jurnal Ilmiah Mahasiswa Universitas Surabaya (September)
Publisher : Perpustakaan Universitas Surabaya

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Abstract

ABSTRAK Vaginosis Bakterial (VB) adalah suatu kondisi perubahan ekologi vagina yang ditandai dengan pergeseran keseimbangan flora vagina yaitu dominasi Lactobacillus digantikan oleh bakteri anaerob. Penelitian ini menggunakan metode Kuasi Eksperimental Non Equivalent Control Group Design untuk mengetahui pengaruh penambahan probiotik oral terhadap efek antimikroba metronidazole pada terapi Vaginosis Bakterial (VB) pada pasien yang tidak hamil di Surabaya. Penelitian dilakukan di RSIA Kendangsari Surabaya. Outcome yang diukur adalah penilaian kriteria BV menurut kriteria Amsel, Skor Nugent, dan kondisi klinis vagina pasien. Terdapat pengaruh yang tidak signifikan (p>0,05) penambahan probiotik tehadap efek antimikroba metronidazole terapi Vaginosis Bakterial (VB) menurut kriteria Amsel dan kondisi klinis vagina antara kelompok Probiotik dan Metronidazole maupun dengan Metronidazole. Penelitian ini menunjukkan bahwa penambahan probiotik terhadap efek antimikroba metronidazole terapi BV pada pasien yang tidak hamil, berdasarkan hasil Skor Nugent berpengaruh secara signifikan (p<0,05) karena Skor Nugent merupakan gold standard pada pemeriksaan Vaginosis Bakterial (VB). Kata Kunci: Pengaruh, Vaginosis Bakterial, Metronidazole, Probiotik ABSTRACT Bacterial Vaginosis (BV) is a condition ecological vagina changing that indicated by flora vagina shifting balance, dominated by Lactobacillus replaced by anaerobe bacterials. This research using Quasy Experimental Non Equivalent Control Group Design method to indicate probiotic addition to antimicrobial metronidazole effect in Bacterial vaginosis therapy (BV) for impregnant woman in Surabaya. Bacterial vaginosis therapy (BV) Metronidazole tablet and Probiotic oral. The research has been doing in RSIA Kendangsari Surabaya. Measured Outcome is using BV measurement criteria according to Amsel criteria, Nugents Score, and patient’s vagina clinical condition. There are insignificantly effects (p>0,05) probiotic addition to antimicrobial metronidazole Bacterial vaginosis effect (BV) therapy according to Amsel criteria and vagina clinical condition between Probiotic group, Metronidazole, as well as Metronidazole. This research indicates probiotic antimicrobial metronidazole BV therapy effect addition to impregnant patient, according to Nugent Score significantly affected (p<0,05) because Nugent Score is the gold standard to Bacterial vaginosis (BV) checking. Keywords: Impact, Bacterial Vaginosis, Metronidazole, Probiotic
Comparison Of The Effectiveness And Safety Of Anemia Epoetin Alfa With Epoetin Beta Inhemodialysis Routine Patients At Haji Rsu Surabaya Gunawan Widodo; Anita Purnamayanti; Hesti Trisnianti Burhan Burhan; Burhan
Saintika Medika Vol. 17 No. 2 (2021): December 2021
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol17.SMUMM2.18228

Abstract

Chronic Kidney Disease (CKD) is a disorder of the structure / function of kidney> 3 months marked by pathology and renal damage marker and impairment Glomerular filtration rate (GFR). Erythropoietin is agrowth factor hematopoietic that plays a role in the formation of red blood cells 5. Research conducted by Henry et al, on the pharmacokinetics of epoetinalfa showed the results that epoetinalfa has the effectiveness of increasing Hb concentration within 2-6 weeks with a half-life of 4-5 hours. Epoetin therapy was given with indications of Hb< 10 g/dL, no absolute iron deficiency anemia Transferrin Saturation > 20%, Serum Ferritin and no severe infection. At RSU HAJI, the insurance company bears the cost of administering epoetinalfa at a dose of 3000 IU and epoetin beta at a dose of 2000 IU to anemic patients undergoing HD, with several written conditions, namely the administration of epoetinalfa/beta given twice a week ,Hb< 10 g/dL, TSAT > 20%, FS > 200 ng/L, and no severe infection. The research subjects were divided into 2 groups, namely a group of patients receiving treatment for epoetin alpha 3000 IU/2x a week and a group of patients receiving epoetin beta anemia therapy 2000 IU/2x a week, with the direction of data collection being a combination of retrospective methods. Based on the results of research that has been conducted on the comparison of the effectiveness and safety of anemia therapy with epoetinalfa and epoetin beta in routine hemodialysis patients at RSU HAJI Surabaya.
Perbandingan Keberhasilan Terapi Antivirus Favipiravir dan Remdesivir pada Pasien Covid-19 di RSUD dr. Doris Sylvanus Rhatna Dewi Riptasari; Abdul Rahem; Anita Purnamayanti
Jurnal Surya Medika (JSM) Vol 8 No 1 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v8i1.3453

Abstract

All drugs used for COVID-19 therapy are circulated under a particular scheme, namely the Emergency Use Authorization (EUA) from the Food and Drug Administration. Considering that this COVID-19 is a new case, the high mortality rate, and the lack of research related to COVID-19 drug therapy in Central Kalimantan, a study was conducted to compare the success of COVID-19 treatment in severe patients using remdesivir and favipiravir antivirals with clinical evidence parameters. Number Needed To Treat (NNT) at the COVID-19 referral service at RSUD dr. According to inclusion, Doris Sylvanus in 140 study subjects was divided into 70 topics, each using favipiravir and remdesivir. The results of the study in the remdesivir group showed that 36 (51.43%) subjects recovered and 34 (48.57%) died, while in the favipiravir group, 48 (68.67%) recovered and 22 (31.43%) died. Calculation of the NNT parameter values for remdesivir was obtained with six results, indicating that it takes six COVID-19 patients to be treated with remdesivir to produce therapeutic success, at least one patient recovers. The ideal NNT value is number 1; the smaller the NNT value is close to 1, the more effective it is to produce the expected recovery or positive impact. On the other hand, the higher the NNT value, the lower the effectiveness.
Studi Efektivitas Profilaksis Cefazolin terhadap Pertumbuhan Koloni Bakteri Pascaoperasi: Studi pada Pasien Patah Tulang Panjang Terbuka Grade I dan Grade II di RSUD dr. Saiful Anwar Malang Thomas E. C. J. Huwae; Rasyidin Rumlus; Wijaya Kartanegara; Dewi Santosaningsih; Anita Purnamayanti; Agustinus Santoso; Rika Yulia
Indonesian Journal of Clinical Pharmacy Vol 9, No 1 (2020)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2020.9.1.1

Abstract

Penggunaan antibiotik profilaksis sebelum tindakan bedah telah terbukti dapat mengurangi angka kejadian infeksi setelah operasi. Antibiotik profilaksis dianjurkan hanya untuk tindakan dengan kejadian infeksi yang tinggi dan tindakan dengan konsekuensi infeksi yang sangat serius. Kasus patah tulang terbuka merupakan kejadian infeksi yang sangat serius. Penelitian ini bertujuan untuk mengetahui efektivitas profilaksis cefazolin terhadap pertumbuhan koloni bakteri 24, 48, dan 72 jam pascaoperasi. Metode pada penelitian ini merupakan metode observasional secara kohort prospektif yang dilakukan di RSUD dr. Saiful Anwar Malang selama Januari–Juni 2018 dan pengambilan sampel menggunakan total sampling. Penilaian efektivitas cefazolin berdasarkan pertumbuhan jumlah koloni bakteri dan sensitivitas bakteri terhadap antibiotik. Hasil pemeriksaan kultur luka operasi pada 30 subjek grade I dan grade II, terdapat 43 koloni bakteri positif yaitu coagulase-negative Staphylococcus dari total 43 koloni bakteri yang tumbuh sehingga mencapai sensitivitas (100%) pada 24 jam pascaoperasi, sedangkan pemeriksaan kultur 48 jam dan 72 jam pascaoperasi tidak terdapat pertumbuhan bakteri. Penggunaan profilaksis cefazolin efektif dalam menurunkan pertumbuhan koloni bakteri 24, 48, dan 72 jam pascaoperasi.Kata kunci: Antibiotik profilaksis, cefazolin, patah tulang terbukaEffectiveness of Cefazolin Prophylaxis on the Growth of Postoperative Bacterial Colony: Study on Grade I and Grade II Open Fracture Patients at Saiful Anwar General Hospital AbstractThe use of prophylactic antibiotics before surgery has been shown to reduce the incidence of postoperative infection. Prophylactic antibiotics are recommended only for procedures with high infection incidence and procedures with very serious infection consequences. The case of open fractures has a very serious infection risk. The purpose of this study was to find out the effectiveness of cefazolin prophylaxis against bacterial colony growth of 24 hours, 48 hours, and 72 hours postoperatively. This was a prospective cohort study conducted in RSUD dr. Saiful Anwar Malang from January to June 2018 using total sampling. Assessment of cefazolin effectiveness was based on the amount of bacterial colony growth and bacterial sensitivity growth to antibiotics. On the examination result of wound culture on 30 grade I and II subjects after 24 hours, 48 hours, and 72 hours postoperatively, there were 7 positive isolated specimens of coagulase-negative Staphylococcus with bacterial colony of 7 (100%) for 24 hours postoperatively while culture examination for 48 hours and 72 hours postoperatively did not have bacterial growth (100% sensitivity). It was concluded that the use of cefazolin prophylaxis was effective in reducing the growth of bacterial colony for 24 hours, 48 hours, and 72 hours postoperatively.Keywords: Cefazolin, open fractures, prophylaxis antibiotic
Kesalahan Penggunaan Obat Ibu dan Balita Peserta Posyandu di Kecamatan Sukolilo, Surabaya Anita Purnamayanti; Agnes Nuniek Winantari; Nani Parfati; Ida Diana; Nurul Latifah; Tri Setyowati
MPI (Media Pharmaceutica Indonesiana) Vol. 1 No. 1 (2016): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (634.802 KB) | DOI: 10.24123/mpi.v1i1.51

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Kesalahan penggunaan obat (Medication Administration Error, MAE) pada ibu hamil dan anak merupakanjenis kesalahan penggunaan obat yang lazim dijumpai di komunitas. Orang tua berperan pentingdalampemberian obat bagi anak, terutama pada balita. Pos Pelayanan Terpadu (Posyandu) di Indonesia merupakanUpaya Kesehatan Berbasis Masyarakat (UKBM) yang secara terpadu meningkatkan kesehatan ibu dan balita,yang bertujuan untuk mengatasi ketimpangan akses terhadap fasilitas pelayanan kesehatan maupun terhadaptenaga kesehatan. Penelitian observasional yang dilaksanakan di Posyandu di Kecamatan Sukolilo secara prospektifini dirancang untuk mengkaji kesalahan penggunaan obat yang mungkin terjadi di masyarakat. Sukolilomerupakan Kecamatan yang unik, karena keragaman di bidang sosioekonomi, maupun kemampuan masyarakatnyauntuk mengakses tenaga kesehatan dan fasilitas pelayanan kesehatan. Penelitian ini berlangsung selamabulan Januari sampai Mei 2013, dengan metode wawancara penggunaan obat oleh ibu hamil dan orang tua untukanak balitanya. Hasil penelitian dikelompokkan berdasarkan algoritma dan diagram National CoordinatingCouncil for Medication Error Reporting and Prevention. Terdapat MAE pada penggunaan obat ibu hamil dan balita.Jenis kesalahan penggunaan obat yang tersering adalah “Terjadi kesalahan, tidak membahayakan” kategori“B”, “C”, dan “D”. Selain itu, “Terjadi kesalahan, Membahayakan” kategori “E” dan “F” juga terdapat, namun tidakada “Terjadi Kesalahan, Mematikan”. Jenis MAE tersering adalah “obat tidak diberikan”, dan “dosis dan frekuensiobat tidak tepat”, terutama pada penggunaan antibiotik. Kesalahan ini dapat dicegah melalui pemberian edukasikepada orang tua untuk meningkatkan pemahaman mengenai cara penggunaan obat.