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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Rika Yulia
Department of Clinical and Community Pharmacy, Faculty of Pharmacy, University of Surabaya, Surabaya, Indonesia
Chemistry Education Health Professions Medicine & Pharmacology Other

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Analysis of Antibiotic Use in COVID-19 Patients at a Hospital in Sidoarjo Weni Kristanti; Rika Yulia; Fauna Herawati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.200-208

Abstract

Background: Antibiotics are given to COVID-19 patients to treat bacterial co-infections, but excessive and inappropriate antibiotic use can increase antibiotic resistance. Objective: The study aims to analyze the antibiotic use and bacterial susceptibility in COVID-19 patients at a hospital in Sidoarjo - East Java. Method: The research design used was a prospective cross-sectional study using data collection of sputum culture, bacterial susceptibility, medical records, and Pharmacy antibiotics usage from August to October 2021. The Research sample is moderate-to-severe COVID-19 patients. Result: The results showed that in August-October 2021, 32 patients met the study sample category, where the most were men (56.25%), age range 46-55 years (31.25%), and outcome recovered as much as 81.25%. The culture results showed that only 1 (one) person out of 32 samples had bacterial growth. The only bacteria that grew in the sputum culture was Enterobacter aerogenes, susceptible to meropenem but resistant to levofloxacin. The highest quantity of antibiotics in this study was levofloxacin 71,16; meropenem 32.25; moxifloxacin 21.84 DDD/ 100 bed days. Conclusions: Most of the cases of COVID-19 occurred in men; the age range was 46-55 years, and the outcome recovered was more than those who died. Bacterial co-infection occurred in 3.12% of patients who received meropenem and levofloxacin during their hospitalization. The largest quantity of antibiotics used was levofloxacin, meropenem, and moxifloxacin. The combination of meropenem and levofloxacin should be re-evaluated because levofloxacin is resistant but still susceptible to meropenem.
Analysis of Drug Use in Non-Ventilator Covid-19 Patients at Bangil Hospital Vincentina Yenny Triamyanti; Fauna Herawati; Rika Yulia; Abdul Kadir Jaelani
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.168-176

Abstract

Background: Coronavirus Disease 2019 (Covid-19) is an infectious disease. Common signs and symptoms of Covid-19 infection include acute respiratory distress such as fever, cough and shortness of breath. Analysis of drug use in Non-Ventilator Covid-19 patients needs to be carried out to provide an overview of drug therapy currently being used based on the Covid-19 Management Guidelines Edition 3rd because so far, there has not been a single type of drug that has received marketing authorization for Covid-19 therapy. Objectives: This study aims to determine patient profiles, therapeutic outcomes, suitability of drug use with Covid-19 Management Guidelines 3rd edition, the quantity of antibiotic use using the DDD/100 patient-days method and antivirals. Methods: The method used in this study is an observational design study which was analyzed descriptively with retrospective data collection. Result: Based on the profile of drug use in COVID-19 patients, there are 31 types of drug classes. The most consumed drugs were antibacterial (91%) and analgesics (91%), followed by vitamins (89%) and supplements (85%). Based on the DDD/100 patient-days value, the most widely used antibiotics were Azithromycin. Conclusion: The patient's profile at the time of admission to the hospital was 44% moderate and 56% severe. The condition of patients at the time of discharge from the hospital with a moderate degree using antivirals and antibiotics were more recovered and returned home with improvements with percentages of 84.1% and 88.64%, respectively.
Co-Authors Abdul Kadir Jaelani Fauna Herawati Vincentina Yenny Triamyanti Weni Kristanti