Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Edumedia: Jurnal Keguruan dan Ilmu Pendidikan
Alief Putriana Rahman
Unknown Affiliation
Chemistry Education Health Professions Medicine & Pharmacology Other

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
The Effect of Vitamin C Addition on Epigallocatechin Gallate (EGCG) Stability in Green Tea Solution Alief Putriana Rahman; Djoko Agus Purwanto; Isnaeni Isnaeni
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 6 No. 2 (2019): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v6i22019.62-68

Abstract

Background: Epigallocatechin gallate (EGCG) is the most abundant green tea catechin with a powerful antioxidant effect to prevent cancer cells. EGCG in green tea solution is highly susceptible to degradation, this it is urgent to  increase the stability of EGCG by vitamin C addition. Vitamin C can regenerate radical EGCG to be normal EGCG. Objective: This research aim was to determine percent of decreased level of EGCG before and after vitamin C addition. Methods: This paper was focused on enhancing the stability of EGCG by 1 mg (GTVC1), 1.5 mg (GTVC2), 2 mg (GTVC3), 2.5 mg (GTVC4) and 3 mg (GTVC5) of vitamin C addition to 10 g/L of green tea solution concentration. Evaluations of EGCG were conducted at 0 days, 1 day, 2 days, 3 days, and 4 days of storage time. EGCG was analyzed using thin layer chromatography (TLC) densitometry methods. The stability of EGCG was determined by % of decreased EGCG. Results: Percent of loss of EGCG in GT, GTVC1, GTVC2, GTVC3, GTVC4 and GTVC5 after 4 days storage were 19.93%, 10.89%, 21.08%, 18.18%, 28.56%, and 9.76%, respectively. Conclusion: This study showed that in 4 days storage, the decreased level of EGCG in green tea solution with 3 mg of vitamin C addition (GTVC5) was 9.76% which was smaller than green tea solution without vitamin C addition (GT) which EGCG decreasing 19.93%.
EKSPLORASI POTENSI SENYAWA SHOGAOL, ZINGERONE, PIPERIDINE, GINGEROL, GINGERDIONE PADA JAHE (Zingiber officinale) SEBAGAI AFRODISIAK MELALUI PENDEKATAN IN SILICO Pradila, Faiq; Taufikurrahman, Taufikurrahman; Alief Putriana Rahman
Edumedia : Jurnal Keguruan dan Ilmu Pendidikan Vol 9 No 2 (2025): Edumedia: Jurnal Keguruan dan Ilmu Pendidikan
Publisher : Universitas Kapuas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51826/edumedia.v9i2.1629

Abstract

Disfungsi ereksi (DE) merupakan salah satu bentuk gangguan seksual yang banyak dialami oleh pria dan seringkali ditangani dengan obat-obatan sintetis seperti sildenafil sitrat yang memiliki efek samping serius. Jahe (Zingiber officinale) mengandung senyawa aktif seperti gingerol, shogaol, zingerone, piperidine, dan gingerdione yang diduga memiliki aktivitas afrodisiak. Penelitian ini bertujuan untuk mengevaluasi potensi senyawa aktif dalam jahe sebagai afrodisiak melalui pendekatan in silico dengan target enzim Phosphodiesterase tipe 5 (PDE5). Metode yang digunakan meliputi preparasi ligan dan reseptor, uji farmakokinetik (Lipinski dan ADMET), validasi metode docking, dan analisis molecular docking menggunakan AutoDock Vina. Hasil penelitian menunjukkan bahwa senyawa gingerol dan gingerdione memiliki nilai binding affinity paling kuat terhadap enzim PDE5, masing-masing sebesar −7,7 dan −7,4 kcal/mol, mendekati nilai kontrol sildenafil (−10,1 kkal/mol). Kedua senyawa juga berikatan pada sisi aktif enzim melalui interaksi hidrogen dan hidrofobik. Seluruh senyawa memenuhi kriteria farmakokinetik dan tidak menunjukkan potensi toksik. Berdasarkan temuan tersebut, jahe berpotensi dikembangkan sebagai afrodisiak alami alternatif yang lebih aman dibandingkan obat sintetis.
Co-Authors Djoko Agus Purwanto Isnaeni Pradila, Faiq Taufikurrahman Taufikurrahman