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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga.
Hanna Cakrawati
Lecturer of Medical Faculty, University of Muhammadiyah Malang. Indonesia jl. Bendungan Sutami No.188a Malang
Health Professions Medicine & Pharmacology Public Health

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Comparison Between Physical Exercise and Alendronate Against Bone Calcium Levels and Body Weight In Wistar Rats Model Glucocorticoid-Induce Osteoporosis Hanna Cakrawati; Minarma Siagian; Neng Tine Kartinah
Saintika Medika Vol. 18 No. 1 (2022): June 2022
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol18.SMUMM1.21570

Abstract

Glucocorticoid-induce osteoporosis (GIO) is a bone condition with osteoporosis due to taking long-term glucocorticoid drugs which is the most common cause of increasing the number of fracture cases which is a health problem. GIO is one of the most common forms of osteoporosis in men. Sodium alendronate is a biphosponate drug that is approved for prevention and management of GIO but has serious side effects on long-term use. Doing physical exercise "weight-bearing exercise" such as running is known to increase BMD (Bone Mineral Density) and can reduce osteoponia and the risk of osteoporosis. This study was a study with experimental studies, using male Wistar rats aged 8 weeks divided randomly into 4 groups, namely 1) positive control group (given oral prednisolone 0.54 mg/200g/day), 2) negative control group (not given oral prednisolone), 3) physical exercise group and 4) oral administration group of sodium alendronate (0.09 mg / 200g / day). Bone density will be measured by measuring the calcium level of the tibia bone using the AAS (Atomic Absorptions Spectrophotometer) method and the body weight of mice using scales. The results showed that physical exercise and sodium alendronate significantly affected p = 0.029 with (p <0.05) increasing calcium levels in rats induced by glucocorticoids and obtained p = 0.064 with (p <0.05) in this study there was no difference significant body weight difference between research groups
The Effect of Length of Work on Dry Eyes Disease in Madurese Becak Workers, Sumenep Regency Bragastio Sidharta; RA. Erlinda Manggarsari; Hanna Cakrawati
Saintika Medika Vol. 19 No. 1 (2023): June 2023
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol19.SMUMM1.29244

Abstract

Dry eye disease (DED) is a disorder of the tear film caused by reduced tear production giving complaints that the eyes feel dry, and gritty and cause a burning sensation, which is one of the reasons patients come to see a doctor. The causes of DED are very multifactorial where ocular, anatomical, systemic, and environmental factors have been reported by several studies which state that there is a relationship between environmental factors such as pollutants from motorized vehicles having a role in the incidence of increased DED. Sumenep Regency was once a city of a thousand pedicabs and until now they are still the favorite choice for the people there. This research is an analytic observational with a cross-sectional approach. Data on the characteristics of the study subjects, length of work, and degree of DED complaints were collected and DED complaints were assessed using the Ocular Surface Disease Index (OSDI) questionnaire. The data were processed and analyzed using the Spearman correlation test to determine the effect of length of service on the level of DED complaints. A moderate strength (Spearman correlation = 0.441) relationship exists between the length of work and the degree of DED complaints in pedicab drivers.
Co-Authors Bragastio Sidharta Minarma Siagian Neng Tine Kartinah Almuktabar RA. Erlinda Manggarsari