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All Journal International Journal of Public Health Science (IJPHS) Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Majalah Kedokteran Bandung The Indonesian Biomedical Journal Universa Medicina Paediatrica Indonesiana Indonesian Journal of Medicine Health and Medical Journal Jurnal Ilmu Faal Olahraga Indonesia Jurnal Kedokteran Meditek The International Journal of Medical Science and Health Research
Neng Tine Kartinah Almuktabar
Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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LOW VITAMIN B12 DIET INCREASES LIVER HOMOCYSTEINE LEVELS AND LEADS TO LIVER STEATOSIS IN RATS Sianipar, Imelda Rosalyn; Ujianti, Irena; Yolanda, Sophie; Jusuf, Ahmad Aulia; Kartinah, Neng Tine; Amani, Patwa; Murti, Krishna Aditya; Soeria Santoso, Dewi Irawati
Universa Medicina Vol 38, No 3 (2019)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (821.825 KB) | DOI: 10.18051/UnivMed.2019.v38.194-201

Abstract

Background Nonalcoholic fatty liver disease (NAFLD) is one of the most widespread chronic liver diseases, caused by the development of insulin resistance. One of the mechanisms involved is a disturbance in insulin signaling by certain toxic substances that interact with one of the proteins responsible for the insulin signaling pathway. Increased homocysteine level, upon disruption of the methionine pathway, is associated with insulin resistance. The aim of this study was to evaluate the effect of hyperhomocysteinemia and insulin resistance (HOMA-IR level) induced by dietary vitamin B12 restriction on liver steatosis. Methods A study of laboratory experimental design was conducted involving 18 male Sprague Dawley rats (age 36-40 weeks, BW 300-350 g), that were randomly divided into 3 groups: control, 8-week treatment, and 16-week treatment. Standard AIN-93 diet was administered to the control group, whereas rats in the treatment groups were fed vitamin B12 deficiency-AIN-93M. At the end of treatment, liver homocysteine levels were determined by ELISA, HOMA-IR values were calculated, and steatosis degree of the liver was determined histologically. Statistical analysis was performed using independent t-test. Results A significant increase in liver homocysteine levels was found between the control and both the 8- and 16-week treatment groups (p<0.001). HOMA-IR levels were significantly higher in both treatment groups compared to controls (p<0.001). The area of liver steatosis in both treatment groups was significantly larger than that of the control group (p<0.001). Conclusion Increased homocysteine levels due to dietary vitamin B12 deficiency induces liver steatosis due to insulin resistance in rats.
Respons Insulin Like Growth Factor-I Pascalatihan Fisik Sebagai Indikator Peningkatan Densitas Tulang pada Wanita Lanjut Usia Almuktabar, Neng Tine Kartinah
Majalah Kedokteran Bandung Vol 42, No 2
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.178 KB)

Abstract

Latihan fisik merupakan salah satu upaya untuk mencegah osteoporosis pada wanita lanjut usia namun sampai saat ini indikator latihan fisik yang efektif, efisien, dan aman dalam meningkatkan densitas tulang pada wanita lanjut usia di Indonesia masih belum diketahui. Tujuan penelitian untuk mengetahui hubungan respons insulin like growth factor I (IGF-I) pascalatihan fisik, progressive resistance exercise (PRE), dan senam pencegahan osteoporosis (SPO) terhadap densitas tulang. Studi kasus eksperimen desain pretes dan postes dilakukan selama 16 minggu periode April-Juli 2005. Subjek penelitian terdiri 18 wanita lansia, usia 55-65 tahun di Puskesmas Ciwaruga Bandung yang memenuhi kriteria inklusi (usia 55-56 tahun, dan tidak mengkonsumsi obat-obatan yang berpengaruh buruk terhadap densitas tulang). Analisis statistik yang digunakan uji hubungan regresi linier berganda untuk menguji hubungan respons akut dan kronik IGF-I terhadap densitas tulang. Hasil uji regresi linier berganda respons akut dan kronik IGF-I terhadap densitas tulang pada kelompok PRE dan SPO menunjukkan titik defleksi nilai densitas tulang sebesar 0,88 dan 0,83 g/cm2 (p= 0,000). Persamaan regresi densitas tulang pada kelompok PRE =0,229 - 0,0005 respons akut + 0,00006 respons kronik (p<0,05). Persamaan regresi pada kelompok SPO menunjukan densitas tulang= 0,158 - 0,0002 respons akut + 0,00009 respons kronik (p<0,05). Dapat disimpulkan bahwa PRE lebih efektif dan efisien dibanding SPO.The Response of Insulin Like Growth Factor-I After Having Exercise As an Indicator for Increasing Bone Density in the Elderly WomenPhysical exercise is an effort for preventing osteoporosis in the elderly women. However, some indicators for effective, efficient, and safe physical exercises for increasing bone density in the elderly women in Indonesia are still questioning. The main purpose of research was to identify the response's correlation of IGF-I post-exercise progressive resistance exercise (PRE) and osteoporosis prevention exercise (SPO) on bone density. The experiment with pre-test and post-test design has been done for 16 weeks on April-July 2005. The subjects of this research were 18 elderly women in Ciwaruga Health Community Center (Puskesmas) that met some inclusion criteria (55-65 years old, health, and do not consume medicines which have bad effects to bone density). The multiple regression test used as statistical analysis to identify the correlation of acute and chronic responses of IGF-I on bone density. The multiple regression analysis of acute and chronic responses of IGF-1 on bone density on PRE and SPO group showed a deflection point of bone density as much as 0.88 and 0.83g/cm2 (p= 0.000). The regression model of bone density on PRE group=0.239 - 0.0005 acute response + 0.00006 chronic response (p< 0.05). The regression model on SPO:Bone density= 0.158 - 0.0002 acute response + 0.00009 chronic response (p< 0.05). Conclusion: the safe indicator for initial bone density before doing PRE and SPO exercises are 0.88 g/cm2 and 0.83 g/cm2 respectively. Therefore, PRE is relatively more effective and efficient than SPO because PRE has high exercise intensity that can increase bone density in short duration than SPO. DOI: http://dx.doi.org/10.15395/mkb.v42n2.11
Healthy family index assessment through community-based health information system approach Rico Kurniawan; Ryza Jazid Baharuddin Nur; Sayekti Yuliyanti; Dion Zein Nuridzin; Neng Tine Kartinah
International Journal of Public Health Science (IJPHS) Vol 10, No 2: June 2021
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v10i2.20751

Abstract

The healthy Indonesia program with a family approach (PIS-PK) has not been implemented optimally. There are several obstacles and challenges in this program’s implementation, e.g., human resources. A community-based health information system (CBHIS) is a strategic approach to obtain data and information at the population level by directly involving cadres and the community. A project with the CBHIS approach was implemented in Kasemen Village, Serang, Banten Province, Indonesia to support the PIS-PK program. The study aimed to determine the population’s health status according to the healthy family index through the CBHIS approach. The data of healthy family indicators in the village were collected by cadres using a mHealth application. Overall, 1316 households consisting of 5312 residents were registered. The analysis results of the healthy family index showed that most families in the Kasemen subdistrict were pre-healthy (64.2%), almost one third were unhealthy (27.8%) and only a small proportion were healthy (8%). Assessing the healthy family index through the CBHIS approach can support decision-making at the community level, thereby determining the magnitude of family health problems and providing appropriate interventions to improve community health status. Well-trained cadres equipped with better electronic data collection tools may be an alternative to community-based data collection.
PERAN LATIHAN FISIK DALAM PENANGANAN OBESITAS: AKSI IRISIN PADA PROSES PENCOKELATAN Dewi Irawati Soeria Santoso; Imelda Rosalyn Sianipar; Neng Tine Kartinah
JURNAL ILMU FAAL OLAHRAGA INDONESIA Vol 3, No 1 (2020)
Publisher : PAIFORI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (890.616 KB) | DOI: 10.51671/jifo.v3i1.86

Abstract

In recent years, the prevalence of obesity continues to increase, leading to a public health problem. Therefore, the obesity problem needs serious attention and treatment approaches. Exercise is one of the treatment approach to combat obesity because exercise plays a role in beiging/browning process. Beiging is a differentiation process from white adipocyte to beige adipocyte, which has similar characteristics to brown adipocyte and is marked with an increase of UCP-1 expression. Irisin plays a role in increasing UCP-1 expression by activating p38 mitogen-activated protein kinase (MAPK) and extracellular-signal regulated kinase (ERK) signaling. Muscle contraction during exercise can activate PGC-1α, which leads to the synthesis of irisin. Exercise may increase irisin levels in skeletal muscle and consequently, play as a mediator of beiging process in adipose tissue.
Environmental Enrichment and Aerobic Exercise Enhances Spatial Memory and Synaptophysin Expression in Rats Diah Ayu Aguspa Dita; Nurul Paramita; Ria Kodariah; Neng Tine Kartinah
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.945

Abstract

BACKGROUND: Exposure to environmental enrichment has a positive effect on brain function, including improved cognition. Environmental enrichment has many aspects, including social interactions, object stimulations, and physical activities. Exercise and environmental enrichment can be considered to improve cognitive function with different underlying mechanisms. This study aims to compare the effects of environmental enrichment and aerobic exercise at both synaptic and whole-organism levels using synapyophysin as a measure of synaptic physiology and spatial memory as a measure of cognitive function.METHODS: A six-week in vivo experimental study on 15, 6-month old male Wistar rats randomly divided into three groups (n=5): aerobic group (A), enriched environment group (EE), and enriched with an aerobic or combined group (EEA). All rats were tested four times in the Water-E maze (WEM) task at weeks 0, 2, 4, and 6 of the study. We used immunohistochemistry to determine the synaptophysin expression in hippocampal CA1 region.RESULTS: Based on synaptophysin immunostaining, there were higher optical density scores for synaptophysin in hippocampal CA1 region following EEA, but there were no statistically significant differences between groups (ANOVA test, p>0.05). The spatial memory test showed there were significantly reduced travel time and total errors from the 2nd and 4th weeks in the EEA group, respectively (p<0.05).CONCLUSION: The combination of enriched environment and aerobic exercise seems to rapidly improve spatial memory and enhances the presynaptic protein, synaptophysin in hippocampal CA1 region.KEYWORDS: aerobic exercise, environmental enrichment, spatial memory, synaptophysin, Water-E maze
Associations of maternal body composition and nutritional intake with fat content of Indonesian mothers’ breast milk Ardesy Melizah Kurniati; Diana Sunardi; Ali Sungkar; Saptawati Bardosono; Neng Tine Kartinah
Paediatrica Indonesiana Vol 56 No 5 (2016): September 2016
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1849.284 KB) | DOI: 10.14238/pi56.5.2016.297-303

Abstract

Background Breast milk is the best sole food for infants in their first six months of life. Breast milk fat content accounts for the largest part of infants’ energy and may be influenced by many factors, including maternal factors, which may vary in different settings. So far, there has been no published data about the breast milk fat content of Indonesian mothers, including whether it is affected by their body composition or nutritional intake.Objective To investigate breast milk fat content of Indonesian mothers and its associations with maternal body composition and nutritional intake. Method This cross-sectional study was conducted at Budi Kemuliaan Mothers’ and Children’s Hospital. Breast milk specimens were collected from 48 nursing mothers, centrifuged, and tested by creamatocrit for fat content. A 24-hour food recall was performed to evaluate maternal macronutrient intake. Maternal body composition was evaluated by bioelectric impedance analysis. Univariable correlations between breast milk fat content and either energy and macronutrient intake were assessed using the Spearman rho test.Results All nursing mothers had breast milk fat content within clinically normal range [mean 59.4 (SD 15.9) g/L]. There was no significant correlation between milk fat content and maternal body fat (r = -0.03, P=0.840), total body water (r = 0.09 P=0.509), or muscle mass (r = 0.08, P=0.577). Milk fat content seemed to weakly correlated with maternal fat intake, although it was not statistically significant (r = 0.27, P=0.065).Conclusion Breast milk fat content at one-month post delivery appears not associated with with maternal body composition. It seems to weakly correlate with maternal fat intake but findings need to be confirmed in larger studies with adjustment for confounding variables. 
Comparison Between Physical Exercise and Alendronate Against Bone Calcium Levels and Body Weight In Wistar Rats Model Glucocorticoid-Induce Osteoporosis Hanna Cakrawati; Minarma Siagian; Neng Tine Kartinah
Saintika Medika Vol. 18 No. 1 (2022): June 2022
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol18.SMUMM1.21570

Abstract

Glucocorticoid-induce osteoporosis (GIO) is a bone condition with osteoporosis due to taking long-term glucocorticoid drugs which is the most common cause of increasing the number of fracture cases which is a health problem. GIO is one of the most common forms of osteoporosis in men. Sodium alendronate is a biphosponate drug that is approved for prevention and management of GIO but has serious side effects on long-term use. Doing physical exercise "weight-bearing exercise" such as running is known to increase BMD (Bone Mineral Density) and can reduce osteoponia and the risk of osteoporosis. This study was a study with experimental studies, using male Wistar rats aged 8 weeks divided randomly into 4 groups, namely 1) positive control group (given oral prednisolone 0.54 mg/200g/day), 2) negative control group (not given oral prednisolone), 3) physical exercise group and 4) oral administration group of sodium alendronate (0.09 mg / 200g / day). Bone density will be measured by measuring the calcium level of the tibia bone using the AAS (Atomic Absorptions Spectrophotometer) method and the body weight of mice using scales. The results showed that physical exercise and sodium alendronate significantly affected p = 0.029 with (p <0.05) increasing calcium levels in rats induced by glucocorticoids and obtained p = 0.064 with (p <0.05) in this study there was no difference significant body weight difference between research groups
Potensi Hibiscus sabdariffa Linn. Memodulasi GLP-1 dan Neuropeptide Y (NPY) di Nucleus Arcuatus pada Tikus Obes Rickie; Neng Tine Kartinah; Minarma Siagian; Nurhadi Ibrahim; Suci Anggraini
Jurnal Kedokteran Meditek Vol 28 No 2 (2022): MEI-AGUSTUS
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v28i2.2346

Abstract

Gangguan pada pusat pengaturan nafsu makan dapat menyebabkan obesitas. Glucagon like Peptide -1 (GLP-1) dan Neuropeptide Y (NPY) merupakan dua peptida penting yang terlibat dalam pengendalian nafsu makan. Beberapa penelitian menunjukkan Hibiscus sabdariffa Linn. memiliki potensi dalam pengendalian obesitas dengan memodulasi kadar GLP-1 dan NPY di perifer. Penelitian ini bertujuan untuk mengetahui bagaimana potensi Hibiscus sabdariffa Linn.(HSL) dalam memodulasi kadar GLP-1 dan NPY di sentral khususnya di Nucleus Arcuatus. Penelitian ini merupakan penelitian lanjutan yang menggunakan jaringan otak tikus tersimpan yang berasal dari 24 ekor tikus Spraque Dawley jantan umur 6 -10 minggu, berat badan antara 90 -160 gram, yang dibagi dalam 4 kelompok yaitu: Normal(C); Obes(Ob); Obes-Hib200(Ob-Hib200); Obes-Hib400(Ob-Hib400). Ekstrak HSL diberikan secara oral satu kali per hari selama 5 minggu. Sampel diperoleh dari hasil isolasi ARC, kemudian dilakukan pengukuran kadar GLP-1 dan NPY menggunakan metode ELISA. Hasil penelitian menunjukkan ekstrak HSL dosis 400mg/KgBB/hari dapat meningkatkan kadar GLP-1 paling tinggi, dibandingkan dengan kelompok tikus lainnya, sekaligus dapat menurunkan kadar NPY dibandingkan dengan kelompok tikus Obes(Ob) dan Obes-Hib(200), meskipun secara analisis tidak terdapat perbedaan bermakna. Dosis ekstrak HSL berperan penting dalam efektifitasnya memodulasi kadar GLP-1 dan NPY di ARC untuk membantu mengendalikan nafsu makan sehingga dapat mengurangi resiko terjadinya obesitas.
The effects of Hibiscus sabdariffa Linn. on the levels of FGF21 and AMPK in the Heart of Diabetic Mice Amelia, Rossa; Goenarjo, Roman Ardian; Kartinah, Neng Tine
The International Journal of Medical Science and Health Research Vol. 3 No. 2 (2024): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/eedvat70

Abstract

Background : Diabetes Mellitus (DM) is a metabolic disorder characterized by pancreatic cell dysfunction and insulin resistance. Fibroblast Growth Factor 21 (FGF21) is thought to have a cardioprotective role. Through FGF21 signaling, AMP-activated protein kinase (AMPK) activity reduces apoptosis, inflammation, hypertrophy, and fibrosis in the heart. Hibiscus sabdariffa Linn. (HSL) contains flavonoids that have hypoglycemic effects and are anti-inflammatory and antioxidant-active. This study aims to assess the effect of HSL on FGF21 and AMPK levels in the heart of diabetic mice models. Methods : An experimental study using Deutschland Denken Yoken (DDY) mice aged eight weeks were divided into four groups: Control, DM Control, HSL 200, and HSL 400. In the DM control, HSL 200, and HSL 400 groups, diabetes was induced by giving a High Fat Diet(HFD) and STZ 40mg/kgbb. The HSL 200 group was given HSL 200mg/kgBB supplementation for three weeks, and the HSL 400 group was given HSL 400 mg/kgBB supplementation for three weeks. FGF21 and AMPK levels were measured using the enzyme-linked immunosorbent assay (ELISA) method. Results : There was no significant difference between FGF21 and AMPK levels between the control and DM control groups. FGF21 and AMPK levels in the HSL 400 group were higher than in the control, DM control, and HSL 200 groups. Conclusions : These findings suggest that HSL supplementation at specific doses can potentially increase the activation of FGF 21 and AMPK signaling in the heart of diabetic mice models.
Effectiveness of Hibiscus sabdariffa Linn for Obesity Treatment: A Systematic Review of Randomized Controlled Trials Anggraini, Suci; Kartinah, Neng Tine
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (31.037 KB)

Abstract

Background: Hibiscus sabdariffa Linn. (H. sabdariffa), commonly known as Rosella plants in Indonesia, has had various uses in the food and beverage industry and traditional medicines for hundreds of years. The main compounds of H. sabdariffa have been stated to have anti-obesity effects through its biologically active compounds. This review systematically evaluates the evidence from human randomized clinical trials on the effects of H. sabdariffa extract in obesity, including decreased bodyweight, normalizing the blood lipid profile, and modulating appetite-related biomarkers.Subjects and Method: This review is based on the patient, intervention, comparison, and outcome (PICO) procedure, with the patient is people with obesity, the intervention is the administration of H. sabdariffa extract compared to control that given placebo, and the outcomes are reduced body weight and fat accumulation, normalize blood lipid profiles, and regulate biomarkers related to appetite. Articles used are limited to the publication year between 2013 and 2021. Search is done through PubMed, ScienceDirect, Wiley Online Library, Scopus, and Google Scholar with the keywords “hibiscus sabdariffa and obesity”, “hibiscus sabdariffa and lipogenesis”, “hibiscus sabdariffa and energy metabolism”, and “hibiscus sabdariffa and appetite”.Results: The search resulted in 10 studies involving 453 subjects. We proved several significant effects of H. sabdariffa extract on obese subjects. Administration of H. sabdariffa extract for several doses and several days can improve anthropometry measurement, fat accumulation, increased satiety sensation, while the appetite sensation mainly for fatty, sweet, and salty foods was decreased.Conclusion: This review suggests that the benefit of H. sabdariffa to people with obesity are associated with body weight and blood lipid profile-lowering effect; however, more high-quality clinical trials are needed.Keywords: Hibiscus sabdariffa, obesity, appetiteCorrespondence: Suci Anggraini, Masters Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia. Jl. Salemba Raya 4, Jakarta Pusat, DKI Jakarta 10430. Email: suci.angraini@ui.ac.id . Mobile: 081363397973.Indonesian Journal of Medicine (2021), 06(04): 439-451https://doi.org/10.26911/theijmed.2021.06.04.10
Co-Authors Ahmad Aulia Ali Sungkar Anggraini, Suci Ardesy Melizah Kurniati Diah Ayu Aguspa Dita Diana Sunardi Goenarjo, Roman Ardian Hanna Cakrawati Imelda Rosalyn Sianipar Irena Ujianti Minarma Siagian Minarma Siagian Murti, Krishna Aditya Nisa Kartika Komara Nuraini Diah Noviati Nurhadi Ibrahim Nuridzin, Dion Zein Nurul Paramita Patwa Amani, Patwa Ria Kodariah Rickie Rossa Amelia, Rossa Ryza Jazid Baharuddin Nur Santoso, Dewi Irawati Soeria Saptawati Bardosono Sari, Widia Sayekti Yuliyanti Sophie Yolanda Suci Anggraini