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Diagnosis Laboratorik Leptospirosis; Gugun, Adang Muhammad
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 6, No 1 (2006)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v6i1.1890

Leptospirosis is a worldwide zoonosis caused by pathogenic leptospira species. Leptospirosis is endemic disease in the tropical urban areas. Leptospirosis must always be considered during the differential diagnosis of other tropical febrile illnesses. Laboratory tests are necessary to confirm the diagnosis of clinically suspected leptospirosis due to its varied symptomatology. Leptospira has extend serogroup. The detection of antigen and antibodies of leptospira are complicated. They depends on the samples available and temporal stage of the illness, sensitivity and spesificity of laboratory method. The conventional tests include direct microscopy, culture and the most widely used reference standard method the microscopic agglutination test but have many limitations. A variety of newer serological tests and those based on molecular techniques have been developed.Leptospirosis merupakan zoonosis di seluruh dunia yang disebabkan oleh spesies leptospira patogen. Leptospirosis merupakan endemis pada daerah urban di negara tropis. Leptospirosis harus selalu dipertimbangkan pada saat menemui penderita dengan demam di daerah tropis. Pemeriksaan laboratorium diperlukan sebagai konfirmasi diagnosis padapenderitayang secara klinis baik gejalamaupun tanda yang sangat bervariasi dicurigai leptospirosis. Leptospira memiliki serogroup yang sangat besar. Deteksi antigen dan antibodi leptospira merupakan permasalahan yang rumit oleh karena dipengaruhi ketersediaan sampel, onset penyakit maupun sensitifitas dan spesifisitas pemeriksaan, seroprevalensi populasi. Pemeriksaan secara konvensional adalah mikroskop secara langsung, kultur, dan metode microscopic agglutination test (MAT) yang secara luas digunakan sebagai standar rujukan, namun pemeriksaan tersebut memiliki banyak keterbatasan. Berbagai macam tes serologi yang baru dan metode yang berbasis molekuler telah dikembangkan.

Profil Pemeriksaan Fragilitas Osmotik Eritrosit di RS. Dr. Sardjito Gugun, Adang Muhammad; Sukorini, Usi
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 2 (2004)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v4i2.1745

Osmotic fragility test (OFT) is performed to differentiate anemia diagnose with erythrocyte physical changing. In thalassemia and hemolytic anemia, OFT probably gave variation results that can cause erroneous anemia etiology tracÂ¬ing. Aims of this research are to describe the OFT profile and its comparison with peripheral blood morphology in thalassemia and hemolytic anemia.The method, this retrospective study was conducted in Dr. Sardjito hospital at January 2002 to June 2004. Chi-Square test was used to compare thalassemia and hemolytic anemia proportion in the OFT groups. OFT results from 61 subÂ¬jects were : increasing 17 (27,8%), increasing-decreasing 17 (27,8%), deÂ¬creasing 15 (24,4%), and normal 12 (20%). There were significantly differ-ence proportions in thalassemia group between decreasing OFT to increasing and normal OFT (p-0,005 ; p=0,002), but no difference to increasing-deÂ¬creasing group. In hemolytic anemia group, the difference proportion found significantly between increasing OFT to normal, increasing-decreasing and decreasing OFT (p=0,03; p-0,005; p=0,000, respectively). In increasing-deÂ¬creasing OFT group, there was no difference in type anemia (p=0,32). MorÂ¬phologically, target cell was found in 81 % of thalassemia, and spherocyte in 70% of hemolytic anemia. In Dr. Sardjito Hospital, OFT gave variation profile and in Thalassemia and hemolytic anemia groups, morphology evaluation are needed to confirm OFT results.Latar Belakang: Pemeriksaan fragilitas osmotik eritrosit (FOE) ini dilaksanakan untuk membantu diagnosis banding beberapa jenis anemia dengan sifat fisik eritrosit berubah. Aplikasi klinis, Talasemia dan anemia hemolitik memberikan hasil bervariasi sehingga dapat menimbulkan kesalahan interpretasi dalam melacak jenis maupun etiologi anemia.Tujuan penelitian ini adalah mengetahui variasi hasil FOE dan kesesuaian gambaran morfologi darah tepi pada talasemia dan anemia hemolitik. Penelitian retrospektif ini dilakukan menggunakan data rekam medik. Subyek adalah pasien yang diperiksa fragilitas osmotik eritrositnya di laboratorium Patologi Klinik RS. Dr. Sardjito antara Januari tahun 2002 sampai dengan Juni 2004. Uji Chi- square terhadap proporsi talasemia dan anemia hemolitik pada kelompok hasil FOE. Dari 61 subyek, variasi hasil FOE meliputi : peningkatan fragilitas 17 (27,8%), penurunan fragilitas 17 (24,4%), campuran peningkatan dan penurunan 15 (27,8%) dan normal 12 (20%). Terdapat perbedaan bermakna proporsi talasemia kelompok penurunun FOE terhadap kelompok peningkatan FOE (p=0,005) dan FOE normal (p= 0,002), namun tidak berbeda bermakna dengan hasil campuran penurunan dan peningkatan fragilitas (p= 0,26). Terdapat perbedaan bermakna proporsi aneÂ¬mia hemolitik pada kelompok dengan peningkatan FOE terhadap kelompok normal FOE, campuran penurunan dan peningkatan FOE dan penurunan FOE (p =0,03; p= 0,005; p= 0,000). Tidak terdapat perbedaan bermakna proporsi jenis anemia pada hasil campuran penurunan dan peningkatan FOE (p= 0,32). Gambaran morfologi darah tepi pada kelompok talasemia, 81% memiliki sel target dan pada kelompok anemia hemolitik, 70% memiliki sel spherosit.Hasil FOE di RS Dr. Sardjito menunjukkan gambaran variasi, talasemia maupun anemia hemolitik membutuhkan konfirmasi morfologi darah tepi untuk meninjau kesesuaiannya.

Peran Imunisasi dalam Pencegahan Hepatitis B pada Pegawai Universitas Muhammadiyah Yogyakarta Gugun, Adang Muhammad; Suryanto, -
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 9, No 2 (s) (2009)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v9i2 (s).1608

The purpose this research is to know endemicity level and prevention hepatitis B. This is a descriptif observational research. Subjects are 87 Medical Faculty of UMY employee. Screening to HBsAg, anti-HBs and anti-HBc are performed by enzyme-linked immunosorbent assay (ELISA) method and investigating about history of ilness and imunisation of hepatitis B by questionnaire. The result showed that one case positive HBsAg (1,1%) included as low endemicity and not found clinical manifestasion. The history showed that 14 person (16 %) have performed hepatitis B immunization, and 73 person (74 %) have never done. Six subject (43%) immunizationed showed positive anti-HBs with low titer. Hepatitis B history are experienced by two person (2,3%), and they have been health based on clinic and laboratory. One of them has anti-HBc negative. Anti-HBs examination showed 18 (21%) positively, 6 person (33%) have immunization history and 12person (67%) are never. There are 8person who have immunization history are negative anti-HBs. Anti-HBc examination showed that 25person (29%) positively, only one person (4%) has hepatitis B illness history and 24person (96%) have no illness history. Concluded that hepatitis endemicity in Medical Faculty UMY is low.Tujuan penelitian ini untuk mengetahui tingkat endemisitas dan upaya pencegahan Hepatitis B di FK UMY. Jenis penelitian adalah observasional deskriftif. Sampel penelitian adalah 87 pegawai Fakultas Kedokteran UMY. Skrining HBsAg, Anti HBs dan Anti HBc dilakukan dengan metode enzyme- linked immunosorbent assay {ELISA), riwayat sakit dan imunisasi hepatitis B dilacak dengan kuesioner. Hasil penelitian menunjukkan terdapat satu kasus HBsAg positip (1,1%) sehingga termasuk endemis rendah dan anamnesanya menunjukkan tidak ada gejala klinis. Riwayat menunjukkan 14 orang (16%) pernah melakukan imunisasi hepatitis B lengkap dan 73 orang (74%) tidak pernah divaksin. Enam orang (43%) dari yang melakukan imunisasi, memiliki anti-HBs positip dengan titer rendah. Riwayat pernah mengalami sakit hepatitis B terjadi pada 2 orang (2,3%) dan telah sembuh secara klinis dan laboratorik. Salah satu subyek dengan riwayat sakit hepatitis B memiliki hasil anti- HBc negatif. Pemeriksaan anti-HBs menunjukkan 18 orang (21%) positip, 6 orang (33%) diantaranya memiliki riwayat imunisasi dan 12 orang (67%) tidak pernah imunisasi. Delapan orang dengan riwayat imunisasi memiliki anti-HBs negatif. Pemeriksaan anti-HBc menunjukkan 25 orang (29%) positip, 1 orang (4%) diantaranya memiliki riwayat sakit hepatitis B, dan 24 orang (96%) tidak memiliki riwayat sakit hepatitis B. Disimpulkan bahwa endemisitas Hepatitis B di Fakultas Kedokteran Universitas Muhammadiyah Yogyakarta rendah.

Hubungan Angka Neutrofil dengan Mortalitas Infark Miokard Akut Utami, Mugi Restiana; Gugun, Adang Muhammad
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 12, No 1 (2012)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v12i1.993

Infark Miokard Akut (IMA) adalah kondisi otot jantung yang tidak mendapatkan cukup darah dan oksigen. Jaringan yang mengalami infark dapat menimbulkan reaksi peradangan pada daerah perbatasan antara infark dengan jaringan hidup. Neutrofil dengan cepat memasuki daerah yang mati dan mulai melakukan penghancuran. Neutrofilia merupakan petanda inflamasi pada kejadian koroner akut dan mempunyai nilai prognostik. Belum ada penelitian yang spesifik pada angka neutrofil sebagai prediktor mortalitas infark miokard akut. Tujuan penelitian ini adalah untuk mengetahui hubungan angka neutrofil dengan mortalitas IMA. Jenis penelitian analitik observasional dengan desain studi kasus kontrol dengan menggunakan rekam medis di RS PKU Muhammadiyah Yogyakarta. Subjek yang memenuhi kriteria inklusi dan eksklusi dikelompokkan menjadi kelompok meninggal dan kelompok yang masih hidup. Didapatkan 146 sampel yang dibagi menjadi 2 kelompok, 38 orang dalam kelompok yang meninggal dan 108 orang untuk kelompok yang masih hidup. Hasil analisis dengan chi square menunjukkan tidak ada hubungan yang bermakna antara kelompok yang meninggal maupun yang masih hidup dengan nilai OR 1,476 (95% CI 0,65-3,22; p=0,368), sehingga dapat disimpulkan bahwa angka netrofil tidak berhubungan dengan mortalitas IMA.Acute Myocardial Infarction (AMI) is an insufficiency of oxygen and blood in myocard. Infarction can induce inflammation reaction in borderline area of infarct and health tissue. Neutrophil enter to infarct area immediately and destroy. Neutrophilia is inflammation marker in acute coroner syndrome and have prognostic value. There is no a specific research about neutrophil as predictor of mortality of acute myocardial infarction. The objective research is to ascertain the relationship between neutrophil counts following acute myocardial infarction during hospitalization. An observational analytical research was done on AMI patients were hospitalized in the PKU Muhammadiyah Yogyakarta Hospital with case control design using medical records. Subject who fulfilled inclusion and exclusion criteria were divided into 2 groups, death group and live group. There were 146 samples which were divided into 2 groups, 38 patients in death group and 108 patients in live group. Chi square test showed that there is no significance statistically between death group and live group with OR 1,44 (95% CI 0,65-3,22; p=0,368). Neutrophil count does not related with mortality of AMI.

Korelasi Gambaran Ultrasonografi Hepar dengan Kadar Alkali Fosfatase Pasien Klinis Hepatitis Sakinah, Herti; Gugun, Adang Muhammad
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2013)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v13i1.1049

Hepatitis adalah penyakit peradangan atau infeksi hati, dengan penyebab virus, bakteri, jamur, parasit dari obat-obatan. Pemeriksaan penunjang diagnostik hepatitis adalah tes fungsi hati, salah satunya adalah alkali fosfatase, yaitu enzim yang berhubungan dengan penanda adanya penyumbatan pada kantung empedu (kolestasis) dan sensitif untuk mendeteksi beragam jenis penyakit parenkim hati. Pemeriksaan ultrasonografi (USG) dilakukan untuk mendeteksi adanya kelainan organ seperti gambaran ekhostruktur, ukuran, permukaan hepar dan vesika felea. Tujuan penelitian ini adalah untuk mengetahui korelasi antara gambaran USG hepar dengan kadar alkali fosfatase pada pasien klinis hepatitis. Jenis penelitian ini observasional analitik dengan desain cross sectional, menggunakan data rekam medis. Data penelitian berjumlah 35. Analisis data menggunakan uji Spearman dan uji Lambda. Hasil penelitian menunjukkan terdapat korelasi antara kadar alkali fosfatase dengan gambaran USG hepar yang meliputi: ekhostruktur (r=0,094, p=0,590), ukuran (r=0,333, p=0,050) dan permukaan hepar (r=0,324, p=0 ,057), vesika felea (r=0,615, p=0 ,001). Disimpulkan bahwa tidak terdapat korelasi yang bermakna antara gambaran ekhostruktur, permukaan, dan ukuran hepar dengan kadar alkali fosfatase, tapi terdapat korelasi yang bermakna antara gambaran vesika felea dengan kadar alkali fosfatase pada pasien klinis hepatitis.Â Hepatitis is the inflammation or infection of the liver. The causes viruses, bacteria, fungi, parasites and drugs. Additional examination a diagnostic of hepatitis are liver function test, such as Alkaline Phosphatase, Alkaline Phosphatase is an enzyme associated with markers of the blockage of the gallbladder (cholestasis) and sensitive for the detection of various types of liver parenchymal disease. Ultrasonography (USG) is to see a imaging ekhostruktur, size, surface liver and vesica felea. The aim of research to know the correlation between liver ultrasound imaging with Alkaline Phosphatase level in clinical hepatitis patient. This study was observational analytic cross-sectional design, using medical records. Research data 35. The analyzes were conducted using Spearmen test and Lambda test. The results showed a correlation between levels Alkaline Phosphatase with an ultrasound image of the liverÂ include: echostructure (r= 0.094, p= 0.590), size (r= 0.333, p= 0.050) and the surface of the liver (r= 0.324, p= 0.057), vesica felea (r= 0.615, p= 0.001). It can concluded that there was no significant correlation between the image echostruktur, surface, and the size of the liver with levels of Alkaline Phosphatase, but there is a significant correlation between the vesica fellea features with Alkaline Phosphatase levels in patients with clinical hepatitis.

Faktor Risiko Lekosituria pada Wanita Usia Reproduksi Gugun, Adang Muhammad
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 7, No 2 (s) (2007): Oktober
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v7i2 (s).1666

The purpose of this research to know the leucocyturia prevalence and its risk factors in reproduction age women. This is an analytic-observational with case-control design, performed in Kraton, Bambang Lipuro, Bantul District, Daerah Istimewa Yogyakarta. The subject are28 women in reproduction age who has leucocyturia (dipstick test) and the control are 54 women with negative leucocyturia. The risk factors of leucocyturia obtain from questionnaire. Relation between the risk factors and leucocyturia analyzed with univariat test. The result showed that leucocyturia prevalence in reproductive age women is 28%. Contact sexual risk factor was significantly relation with leucocyturia (odd ratio : 3,0 (CI 95%: 1,1-7,7; p=0,02) but perineal hygiene pre-coitus wasnâ€™t significant (odd ratio : 0,135 (CI 95%: 0,03 - 0,53; p=0,002).Tujuan penelitian ini adalah untuk mengetahui prevalensi dan faktor risiko lekosituria pada wanita usia reproduksi. Penelitian ini bersifat observasional analitik dengan rancangan case-control di Dusun Kraton, Bambang Lipuro, Kabupaten Bantul Daerah Istimewa Yogyakarta. Subyek penelitian adalah 28 orang wanita usia reproduksi yang mengalami lekosituria (uji dipstick) tanpa kelainan non infeksi dan 54 orang kontrol wanita usia reproduksi lekosituria negatif.. Data faktor risiko lekosituria digali melalui kuesioner. Analisis hubungan faktor risiko dengan lekosituria menggunakan analisis univariat. Hasil penelitian menunjukkan prevalensi lekosituria sebesar 28%. Faktor risiko sering kontak seksual bermakna dengan rasio odds sebesar 3,0 (CI 95%: 1,1-7,7; p=0,02). Kebersihan perineal pre- koitus bermakna dengan rasio odds sebesar 0,135 (CI 95%: 0,03 - 0,53; p=0,002). Faktor arah cebok, penggunaan AKDR, riwayat leukorea dan riwayat kateterisasi tidak bermakna (p0,05).

Prevalensi Seropositif IgM/IgG Toksoplasma pada Wanita Pranikah dan Tinjauan Faktor Risiko Kepemilikan Kucing Sari, Bernadeta Renny Yulianti; Gugun, Adang Muhammad
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 14, No 1 (2014): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v14i1.2379

Toksoplasmosis merupakan suatu penyakit infeksi parasit yang dapat dijumpai hampir di seluruh dunia karena berbagai faktor seperti usia, kebiasaan, gizi, kontak dengan kucing dan konsumsi daging kurang matang. Wanita pranikah memiliki risiko terinfeksi toksoplasma yang berdampak pada kelainan selama kehamilan, kecacatan atau kematian janin. Toksoplasma yang terdeteksi sebelum kehamilan bisa segera diobati sehingga mencegah penularan ke fetus. Penelitian ini bertujuan untuk mengetahui prevalensi seropositif IgM/IgG Toksoplasma pada populasi wanita pranikah dan hubungan kepemilikan kucing dengan prevalensi seropositif IgM/IgG Toksoplasma. Penelitian ini merupakan penelitian obser- vasional analitik dengan pendekatan cross sectional. Subyek penelitian ini adalah wanita pranikah di Kabupaten Bantul berjumlah 90 orang. Data diambil dari hasil kuesioner dilanjutkan pengambilan sampel serum untuk pemeriksaan IgM/IgG anti toksoplasma dengan ELISA. Data dianalisis dengan Fisher test. Hasil menunjukkan 55,6% seropositif Toksoplasma. Ditinjau dari faktor risiko, dari 11 orang berisiko positif memelihara kucing, dan 7 (63,6%) diantaranya seropositif Toksoplasma. Hasil uji Fisher test menunÂ¬jukkan nilai exact test 0,405 (0,05) dan CI: 0,716-1,909. Disimpulkan bahwa tidak ada hubungan antaÂ¬ra faktor risiko kepemilikan kucing dengan seropositif IgM/IgG Toksoplasma pada wanita pranikah di Bantul.Â Toxoplasmosis is a parasitic infection disease that can be found almost all over the world with various factors such as age, habits, nutrition, contact with cats and consumption of undercooked meat. Premarital women have a risk of infection with Toxoplasma that affects the abnormalities during pregÂ¬nancy, disability or death of the fetus. Toxoplasma infection that detected before pregnancy can be treated immediately to prevent transmission to the fetus. This study aims to know the relation between the prevalence of seropositive IgM/IgG Toxoplasma among premarital female population and the relaÂ¬tion between having cats and prevalence of IgM/IgG seropositive toxoplasma. This research is an anaÂ¬lytic observational with the cross sectional approach. Subjects are premarital women that living in Bantul regency amounted 90 sample. The data is taken from questionnaire and serum examined by ELISA to check the IgM/IgG anti Toxoplasma. The data analyzed by Fisher test. The result showed there are 55,6% seropositive IgM/IgG toxoplasma The evaluation of contact with cats risk factor show that 63,6% of 11 respondence are positive having cats. contact with cat risk factor, from 11 women that have positive risk factor, 7 of them have toxoplasma Seropositive (63,6%). Data analysis using Fisher test, show that exact test value 0,405 (0,05) and CI: 0,716-1,909. It is concluded that no correlation between contact with cat risk factor with the IgM/IgG Seropositive of Toxoplasma on premarital women in Bantul.

HbA1c and Blood Pressure Correlation in Patients with Uncontrolled Type 2 Diabetes Mellitus Gugun, Adang Muhammad; Suryanto
Formosa Journal of Sustainable Research Vol. 3 No. 11 (2024): November 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjsr.v3i11.12269

The primary metabolic symptom of diabetes mellitus is hyperglycemia. Analysing HbA1c levels can help determine blood glucose management. Elevations in blood pressure can be caused by abnormalities in the metabolism of glucose. Patients with uncontrolled diabetes mellitus may experience elevated blood pressure. To ascertain whether blood pressure and HbA1c levels are correlated in patients with uncontrolled DM. There were 90 subjects aged between 31-65 years consisting of 48 men and 42 women. HbA1c levels were checked using the boronate affinity method and blood pressure was measured using a sphygmomanometer. Data analysis used the independent difference t-test and Mann-Whitney U test as well as the Spearman correlation test with a significance level of α=0.05. Research subjects had an average HbA1c level of 10 ± 2.08% (7.1-15). Mean systolic blood pressure was 132.75 ± 18.04 mmHg (90-180). The average diastolic blood pressure was 83.28 ± 10.38 mmHg (60-120). Subjects who experienced hypertension were 36.66%. There were no differences in blood pressure between men and women (systolic p=0.70 and diastolic p=0.58). There was no correlation between HbA1c levels and blood pressure (systolic: r=0.022, p=0.81 and diastolic: r=0.022, p=0.81). There was no correlation between duration of DM and blood pressure (systolic: r=.093 and p=0.38 and diastolic: r= -.032 and p=0.76). There was no correlation between HbA1c levels and blood pressure

Analisis Hubungan Usia dan Jenis Kelamin dengan Tingkat Distres Pada Pasien Diabetes Melitus Tipe 2 Cendekia Airenda Muliandika; Gugun, Adang Muhammad; Alayyannur, Putri Ayuni
NUTRIX Vol 9 No 2 (2025): Volume 9, Issue 2, 2025
Publisher : Fakultas Ilmu Keperawatan Universitas Klabat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37771/nj.v9i2.1441

Diabetes Mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia resulting from impaired insulin secretion or insulin resistance. Type 2 DM is the most prevalent form, accounting for approximately 90–95% of all diabetes cases worldwide. In addition to causing physical complications, DM is also closely associated with psychological problems, one of which is distress. Distress in diabetic patients can increase blood glucose levels, exacerbate complications, and reduce quality of life. This study employed a descriptive observational design with a cross-sectional approach. The research instrument used was the Diabetes Distress Screening Scale (DDS), consisting of 17 questions. The study was conducted at PKU Muhammadiyah Gamping Hospital. The sample was obtained through purposive sampling, involving 47 type 2 DM patients who met the inclusion and exclusion criteria. Data were analyzed using the Kruskal–Wallis test with SPSS software. The majority of respondents experienced mild distress (63.8%), followed by moderate distress (29.8%) and severe distress (6.4%). The most influential domains were emotional burden and regimen-related distress, indicating that patients continue to face challenges in accepting their chronic condition and managing daily self-care routines. The Kruskal–Wallis analysis revealed no significant differences in distress levels based on gender (p=0.865) or age (p=0.912). In conclusion, most type 2 DM patients experienced mild distress, with no significant association between age or gender and distress levels. These findings highlight the importance of emotional support and continuous education to improve patients’ quality of life. Diabetes Melitus (DM) merupakan kelainan metabolik kronis yang ditandai oleh hiperglikemia akibat gangguan sekresi atau resistensi insulin. DM tipe 2 merupakan bentuk yang paling banyak diderita, mencapai hampir 90-95% dari seluruh kasus DM di dunia. Selain menimbulkan komplikasi fisik, DM juga berhubungan erat dengan masalah psikologis, salah satunya distres. Distres pada pasien DM dapat meningkatkan kadar gula darah, memperburuk komplikasi, dan menurunkan kualitas hidup. Penelitian ini menggunakan rancangan observasional deskriptif dengan desain cross-sectional. Instrumen penelitian berupa kuesioner Diabetes Distress Screening Scale (DDS) yang terdiri dari 17 pertanyaan. Penelitian dilaksanakan di RS PKU Muhammadiyah Gamping. Sampel penelitian diperoleh dengan teknik purposive sampling, didapatkan sebanyak 47 pasien DM tipe 2 yang memenuhi kriteria inklusi dan eksklusi. Analisis data dilakukan dengan uji Kruskal–Wallis menggunakan SPSS. Mayoritas responden mengalami distres ringan (63,8%), diikuti distres sedang (29,8%) dan distres berat (6,4%). Domain yang paling berpengaruh adalah beban emosional dan perawatan diri, yang menunjukkan bahwa pasien masih menghadapi kesulitan dalam menerima kondisi kronis serta mengelola rutinitas perawatan sehari-hari. Analisis Kruskal–Wallis tidak menemukan perbedaan bermakna tingkat distres berdasarkan jenis kelamin (p=0,865) maupun usia (p=0,912). Kesimpulanya sebagian besar pasien DM tipe 2 mengalami distres ringan. Usia dan jenis kelamin tidak berpengaruh secara signifikan dengan tingkat distres. Hasil penelitian ini menunjukkan pentingnya dukungan emosional dan edukasi berkelanjutan untuk meningkatkan kualitas hidup pasien.

DIFFERENCES IN S-RBD ANTIBODY TITERS OF SARS-CoV-2 POST-VACCINATION AND POST-COVID-19 IN UMY EMPLOYEES THAT DO GENERAL MEDICAL CHECK UP AT AMC MUHAMMADIYAH HOSPITAL YOGYAKARTA Suryanto, Suryanto; Gugun, Adang Muhammad
Cerdika: Jurnal Ilmiah Indonesia Vol. 3 No. 7 (2023): Cerdika : Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/cerdika.v3i7.637

COVID-19 is a global health problem today. Prevention is the best effort, including vaccination. The earliest evidence of the effectiveness of vaccination was marked by an increase in antibody levels. Research is needed to prove the effectiveness of vaccination by measuring levels of SARS-CoV-2 S-RBD antibodies and comparing them with individuals infected with COVID-19. This study aims to determine and prove differences in the levels of SARS-CoV-2 S-RBD antibodies in individuals with a history of COVID-19 vaccination in subjects who have been infected and who have not been infected with COVID-19. The type of research to be conducted is an analytic observational study with a cross sectional design. The variables studied were the levels of SARS-CoV-2 S-RBD antibodies in individuals who received the COVID-19 vaccination. Subjects consist of groups who have experienced infection and who have never been infected with COVID-19. The subjects used in this study were UMY employees who did general post-vaccination check-ups. The sampling technique used purposive sampling method with the inclusion criteria: (i) employees who are actively working (ii) Age 20-56 years (iii) There is a history of infection evidenced by PCR examination evidence (iv) getting vaccinated for more than 2 weeks. Exclusion criteria for employees who have a history of immune or autoimmune deficiency. This research was conducted at AMC Muhammadiyah Hospital. Examination of antibody levels of S-RBD SARS-CoV-2 was carried out using the Elisa method. Data analysis used descriptive method. The research subjects were 90, consisting of 45 subjects who had been exposed and 45 subjects who were not exposed to COVID-19. Subjects exposed to COVID-19 consisted of 25 men and 15 women, while subjects who were not exposed to COVID-19 consisted of 19 men and 26 women. The research subjects were 23 to 64 years old. From the results of the examination of S-RBD SARS-CoV-2 antibody levels, the results showed that the exposed group had a minimum level of 45.16 AU/mL while the maximum level was more than 1,000 AU/mL. In the unexposed group, 12 subjects had levels <3 AU/mL, while the rest had a minimum level of 3.01 AU/mL and a maximum level of 39.6 AU/mL. From this study, it can be concluded that there are differences in the levels of SARS-CoV-2 S-RBD antibodies which are higher in individuals who have been exposed to COVID-19 than individuals who have not been exposed. There are subjects who have not responded to the COVID-19 vaccination.

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