Article Per Year (5 Year)
p-Index From 2020 - 2025
1.037
P-Index
This Author published in this journals
All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Syiah Kuala Sari Pediatri Caring : Jurnal Pengabdian Masyarakat Pediatric Sciences Journal IJRETINA - International Journal of Retina
Susanto Nugroho
Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Brawijaya/Rumah Sakit Umum Daerah Dr. Saiful Anwar, Malang
Agriculture, Biological Sciences & Forestry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

Published : 6 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Prominently Increased of Mannose Binding Lectin (MBL) and Myeloperoxidase (MPO) Levels in Severe Valve Regurgitation and Heart Failure of Rheumatic Heart Disease Rachmania Putri; Renny Suwarniaty; Loeki Enggar Fitri; Susanto Nugroho; Mohammad Saifur Rahman
Journal of Tropical Life Science Vol. 7 No. 2 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.02.04

Abstract

Rheumatic heart disease (RHD) is mediated by an abnormal immunological response following a Streptococcus pyogenes infection that induces a disturbance of oxidants and antioxidants balances. Mannose-binding lectin (MBL) binds to N-acetylglucosamine, a molecule present on the Streptococcus cell wall and human heart valves. There is a disturbance of oxidant and antioxidant balance in rheumatic disease. Myeloperoxidase (MPO) is a marker of oxidative stress and inflammation. This study was aimed to determine the correlation of MBL and MPO levels and severity of valvular regurgitation and heart failure (HF) in RHD patients. A case-control study was conduct using human peripheral blood samples from 32 children aged 6 to 14 years old. The subjects were divided into two groups: 16 RHD patients included in the case group and 16 healthy children as a control group. The level of MBL and MPO was investigated using ELISA method. There were significant differences on MBL and MPO level between patient and control group. The level of MBL and MPO were significantly increased in RHD group, especially on severe valvular regurgitation. There was a strong correlation between MBL and MPO levels and the severity of valvular regurgitation (r = 0.94 and r = 0.88). The least significant diff-erence (LSD) analysis showed that significant difference occurs in the severe heart failure group. Our research revealed that the MBL and MPO levels in pediatric RHD patients were significantly higher than in healthy children. The MBL and MPO levels were significantly correlated with the severity of valvular regurgitation and heart failure.
Co-Authors Arief Rahman Budi Utomo Desy Wulandari Dominicus Husada Hajeng Wulandari I Dewa Gede Ugrasena Irene Ratridewi Ismoedijanto Lely Retno W Loeki Enggar Fitri Marvin Anthony Putera Mohammad Saifur Rahman Nadia Artha Dewi Nanda Juwita Parwati Setiono Basuki Rachmania Putri Renny Suwarniaty Rofa Husnul Khuluqi Savitri Laksmi Winaputri Sony Wicaksono Sony Wicaksono Wisnu Barlianto