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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences AL KAUNIYAH Quagga: Jurnal Pendidikan dan Biologi
Rahadian Yudo Hartantyo
Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Immunology & microbiology Materials Science & Nanotechnology

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Ameliorative Effect of Infused Watercress on Rat Galactopoiesis following Maternal Separation Rahadian Yudo Hartantyo; Ucik Erlitaningsih; Jeremia Gerald; Indah Permata Sari; Laksmindra Fitria; Mulyati Mulyati
Journal of Tropical Life Science Vol. 8 No. 3 (2018)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Galactopoiesis is the maintenance of milk production. The process that regulated primarily by prolactin hormone. The research was conducted to evaluate galactopoiesis activity by measuring prolactin level and milk production continuity of lactating rats after oral administration of infused watercress. Twenty lactating rats were randomly divided into five groups (two control groups and three variations of infused watercress dose groups). Serum prolactin was measured using enzyme-linked immunosorbent assay. Milk yield was measured using indirect milk measurement method by Sampson and Jansen. Milk protein level was measured using Kjedahl method. The treatment of infused watercress (10 g/kg body weight), started from postnatal day 3 until 12, indicated ameliorative effect on rat galactopoiesis by increasing milk yield and prolactin levels, but not milk total protein.
Toksisitas Oral Akut Arthrospira maxima dan Chlorella vulgaris Isolat Glagah Pada Tikus (Rattus norvegicus Berkenhout, 1769) Galur Wistar Laksmindra Fitria; Tika Candra Dewi; Kholidatus Silmi; Mulyati Mulyati; Rahadian Yudo Hartantyo; Slamet Widiyanto; Eko Agus Suyono
Al-Kauniyah: Jurnal Biologi Vol 15, No 2 (2022): AL-KAUNIYAH JURNAL BIOLOGI
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/kauniyah.v15i2.18716

Abstract

AbstrakArthrospira (Spirulina) dan Chlorella adalah mikroalga yang telah dikenal bermanfaat bagi kesehatan sehingga banyak dikembangkan sebagai produk suplemen makanan. Penelitian ini bertujuan untuk mempelajari tingkat ketoksikan dan keamanan mengkonsumsi A. maxima dan C. vulgaris yang diisolasi dari perairan Pantai Glagah di Provinsi D.I. Yogyakarta menggunakan tikus Wistar sebagai model praklinis. Studi toksisitas merupakan langkah awal sebelum dilakukan eksplorasi potensi, pemanfaatan, dan pengolahan kedua mikroalga ini sebagai produk suplemen kesehatan. Prosedur uji toksisitas mengikuti Guideline OECD No. 420. Parameter yang diamati meliputi berat badan, profil hematologis, evaluasi fungsi hati (aktivitas ALT dan kadar bilirubin), serta fungsi ginjal (kadar kreatinin dan asam urat). Berdasarkan hasil, dapat disimpulkan bahwa pemberian per oral A. maxima dan C. vulgaris hingga dosis 5.000 mg/kg bb tidak menunjukkan tanda-tanda ketoksikan, ditunjukkan dengan nilai untuk sebagian besar variabel yang berada dalam kisaran normal. Fluktuasi nilai yang terjadi merupakan wujud dinamika fisiologis normal. Dalam penelitian ini kami mendapat temuan bahwa C. vulgaris menunjukkan potensi sebagai antianemia. Oleh karena studi toksisitas ini adalah dosis tunggal dan terbatas untuk periode akut, maka perlu dilanjutkan dengan studi toksisitas dosis berulang dan periode yang lebih panjang, selain untuk mempelajari ketoksikan dan keamanan juga untuk menggali potensinya.AbstractArthrospira (Spirulina) and Chlorella are microalgae that possess benefits for health, therefore they are Arthrospira (Spirulina) and Chlorella are microalgae that possess benefits for health, therefore they are developed as food supplement products. This study aimed to determine the toxicity and the safety of consuming A. maxima and C. vulgaris isolated from Glagah coastal water in D.I. Yogyakarta Province using Wistar rats as preclinical model. Toxicity study is the first step before exploring the potential, utilization and processing of these microalgae as health supplement products. Toxicity test procedure was performed following OECD Guideline No. 420. Parameters observed included: body weight, hematological profile, and evaluation of liver function (ALT activity and bilirubin level) and renal function (creatinine and uric acid levels). Based on the results, it is concluded that oral administration of A. maxima and C. vulgaris up to dose of 5,000 mg/kg bw demonstrated no signs of toxicity, indicated by values for most of variables were within normal range. Fluctuation in values were manifestation of normal physiological dynamic. In this study, we found that C. vulgaris could be an antianemia potential. Since this toxicity study was a single-dose and limited to acute period, it is suggested to continue with repeated-dose toxicity studies with longer periods to examine the toxicity and the safety of both species besides exploring their potential.
Comparative Analysis of Hematological Profiles in Diabetic Mice Treated with D-Allulose and Neoagaro-Oligosaccharides Salsabila Faradisa Nuris; Wiwin Ariesti; Tri Rini Nuringtyas; Budi Saksono; Rahadian Yudo Hartantyo; Fajar Sofyantoro; Nastiti Wijayanti
Quagga: Jurnal Pendidikan dan Biologi Vol 18 No 2 (2026): QUAGGA : Jurnal Pendidikan dan Biologi
Publisher : Program Studi Pendidikan Biologi, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25134/quagga.v18i2.504

Abstract

Diabetes mellitus is characterized by chronic hyperglycemia that induces oxidative stress and inflammation, contributing to hematological dysfunction and increased systemic risk. This study comparatively evaluated the effects of D-allulose and neoagarooligosaccharides (NAOS) on hematological parameters in BALB/c mice with type 2 diabetes induced by streptozotocin. Experimental groups consisted of control, negative control, positive control (metformin), and treatment groups receiving D-allulose (0.05, 0.1, 0.2 g/kg BW) or NAOS (100, 200, 400 mg/kg BW) orally for 28 days. Hematological assessments included red blood cell (RBC) count, erythrocyte indices (hemoglobin, hematocrit, mean corpuscular hemoglobin), leukocyte count, and lymphocyte levels. Negative controls displayed decreased RBC parameters and lymphocytes, with elevated leukocytes, indicating hematological impairment associated with hyperglycemia. D-allulose improved RBC count, hemoglobin, and MCH, while reducing leukocyte count and elevating lymphocytes, especially at lower doses. NAOS primarily enhanced erythrocyte quality by improving hemoglobin, hematocrit, and MCH, while also modulating leukocyte and lymphocyte profiles. Overall, D-allulose was more effective in restoring erythrocyte quantity, whereas NAOS contributed more prominently to erythrocyte index improvement. Both agents show potential in reducing hematological disorders associated with inflammation in diabetes cases.
Co-Authors Budi Saksono Eko Agus Suyono Fajar Sofyantoro Indah Permata Sari Jeremia Gerald Kholidatus Silmi Laksmindra Fitria Laksmindra Fitria Mulyati Mulyati Mulyati Mulyati Nastiti Wijayanti Salsabila Faradisa Nuris Slamet Widiyanto Tika Candra Dewi Tri Rini Nuringtyas Ucik Erlitaningsih Wiwin Ariesti