Article Per Year (5 Year)
p-Index From 2020 - 2025
0.817
P-Index
This Author published in this journals
All Journal Jurnal Gizi dan Pangan Jurnal Aisyah : Jurnal Ilmu Kesehatan Indonesian Journal of Global Health research Indonesian Journal of Applied Research (IJAR) International Journal of Health and Pharmaceutical (IJHP)
Trini Suryowati, Trini
Departemen Biokimia, FK Universitas Kristen Indonesia, Jl.Mayjen Sutoyo No 2, Jakarta 13630
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Veterinary

Published : 5 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 5 Documents
Search

 1 
Bioactive compounds, antidiabetic and antimicrobial potential of pinang seeds extract (Areca catechu l) Suryowati, Trini; Siagian, Forman Erwin; Maheshwari, Hera; Diani, Yusias Hikmat; Kusuma, Rini Anjarwati
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 3: September 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v8i3.2060

Abstract

Diabetes mellitus is a chronic metabolic disorder affecting people of all ages. The critical aspect of fruits is that rich sources of antioxidants may act in combination with each other phytochemicals to provide their protective effect. Pinang (Areca catechu L.) fruit is edible as the local indigenous plant from West Irian Jaya (Papua) Indonesia. This study was aimed at investigating the biologically active compounds of seeds, fruits, and leaves, the a-glucosidase inhibitory and antibacterial activity of seeds of Pinang against Gram-positive bacteria Staphylococcus aureus ATCC 25923, and Gram-negative bacteria Escherichia coli ATCC 25922. Pinang fruits were extracted by using the maceration method and ethanol solvent. Identify the chemical compounds in seeds by GC-MS technique, test to a-glycosidase inhibitory effect was measured with spectrophotometric. Well, the diffusion method was employed in evaluating the antimicrobial property of extracts. The evaluation of the bioactive compound of Pinang fruits revealed the presence of Vitamin E (0.20%). The inhibition of a-glucosidase of seeds extract of IC50 values was 82.74 ppm, and the global standard was 0.34 ppm. This study confirmed that Pinang seeds contain glucosidase activity that has the potency to inhibit glucose. The antimicrobial activity was performed against bacteria as it showed zone inhibition. These results indicated that Pinang seed extracts exerted potent inhibitory effects against a-glucosidase and inhibited the proliferation of Gram-negative microorganisms.
The Characteristics and Prognosis of Relapsed Patients with Pulmonary Tuberculosis Suryowati, Trini; Marantuan, Randolph Serep; Taneo, Putri Manuella Ussy
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6499

Abstract

Relapsed Pulmonary Tuberculosis is a condition of patients infected with Mycobacterium tuberculosis who have received complete OAT treatment and are declared cured but are re-infected. Based on WHO (World Health Organization) data in 2014, there were 7,840 cases of relapsed pulmonary tuberculosis in Indonesia. This study aims to determine the characteristics and prognosis of relapsed pulmonary tuberculosis patients at the Kramat Jati District Health Centre for the 2021-2022 period. This study uses medical record data with a retrospective descriptive method. In this study, data results were obtained on patients with Relapse Pulmonary Tuberculosis who were treated at the Kramat Jati District Health Center in the period 2021-2022, as many as 34 patients whose criteria met the inclusion criteria. The data obtained were data in the form of age, gender, type of pulmonary tuberculosis diagnosis, occupation or status, previous treatment history, anti-tuberculin drug guidelines, prognosis, which can be used as variables in this study. The data analysis used in this study is using descriptive statistical data methods with frequency analysis. The results showed that patients aged 21-40 years were (32.4%). Male gender (67.6%), bacteriological confirmed diagnosis type (94.1%). Type of employment or other status (58.8%), previous treatment history of relapse patients (61.8%), category 2 OAT guideline patients (82.4%). The prognosis of relapsed pulmonary tuberculosis patients tended to be good (27%). This study concludes that the prognosis of relapsed pulmonary tuberculosis patients with complete treatment category 2 tends to be good.
Comparison Effectiveness of Antidiabetic Activity Extracts of Bay Leaves (Syzygium polycephalum) and Moringa Seeds (Moringa oleifera L.) Suryowati, Trini; Bombing Rombelayuk Allorante, Sealtiel; Pangaribuan, Achnes
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.463

Abstract

The present study reports a comparative evaluation of the antidiabetic potential of ethanol extracts from Syzygium polyanthum (bay leaves) and Moringa oleifera L. (moringa seeds) based on their inhibitory activity against the α-glucosidase enzyme. Diabetes mellitus, a chronic metabolic disorder characterized by hyperglycemia due to impaired insulin secretion or action, can be managed through enzyme inhibition that delays carbohydrate hydrolysis. The investigation was conducted for five weeks using an in vitro experimental method, in which both plant materials were extracted via maceration with 70% ethanol. The α-glucosidase inhibition assay was performed spectrophotometrically at 410 nm, and the half-maximal inhibitory concentration (IC₅₀) was determined to compare the inhibitory capacities of both extracts. Phytochemical profiling revealed that bay leaf extract contains flavonoids, tannins, saponins, and steroids, while moringa seed extract contains flavonoids, alkaloids, and steroids. Results showed that bay leaf extract exhibited strong α-glucosidase inhibition with an IC₅₀ value below 100 ppm, indicating a significant potential as a natural antidiabetic agent. In contrast, moringa seed extract demonstrated weaker activity with no substantial inhibition observed at the tested concentrations. Based on comparative analysis, bay leaf extract shows a higher inhibitory efficiency, suggesting its potential application in herbal antidiabetic formulations. Further studies are recommended to explore the optimal concentration range and bioactive constituents of moringa seeds.
The Effect of Torbangun (Coleus amboinicus Lour) Leaf Extract on Antibiotic Resistant Bacteria Escherichia coli pBR322 and Toxicity Tests on Artemia salina Leach Suryowati, Trini; Yang, John Jackson; Sunarti, Lusia Sri; Bintang, Maria
Indonesian Journal of Applied Research (IJAR) Vol. 5 No. 1 (2024): Indonesian Journal of Applied Research (IJAR)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/ijar.v5i1.388

Abstract

Inappropriate antibiotic use can lead to antibiotic resistance, causing many problems in the treatment of Escherichia coli infection. One way to avoid resistance is to use the traditional medicine Coleus amboinicus Lour, also known as Torbangun in Indonesia. The purpose of this study was to determine the inhibitory ability of 70% ethanol extract of Torbngun leaf against Escherichia coli pBR322 has plasmid pBR322, which is resistant to antibiotics Ampicillin and Tetracycline based on activity and minimum inhibitory concentration. Extraction was carried out using the maceration method. The presence of inhibition zones indicated antibacterial activity. The appearance of the inhibition zone at the minimum concentration indicated the minimum inhibitory concentration. Following this, the cytotoxic activity was evaluated using the brine shrimp lethality test. Data analysis was performed using an unpaired t-test using GraphPad Prism® software. Antibacterial activity tests showed that a 15% torbangun leaf extract concentration had inhibitory power against Escherichia coli pBR322. The toxicity test of torbangun leaf extract against Artemia salina Leach shrimp larvae showed LD50 results at a concentration of 150 ppm.
IDENTIFIKASI KOMPONEN KIMIA DAN AKTIVITAS ANTIOKSIDAN DALAM TANAMAN TORBANGUN (Coleus amboinicus Lour) Suryowati, Trini; Rimbawan, Rimbawan; Damanik, Rizal M; Bintang, Maria; Handharyani, Ekowati
Jurnal Gizi dan Pangan Vol. 10 No. 3 (2015)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (485.092 KB) | DOI: 10.25182/jgp.2015.10.3.%p

Abstract

ABSTRACTThe objective of this study was to determine the chemical compound in leaves, stem, and root by GC-MS technique and antioxidant activity of torbangun leaves (Coleus amboinicus Lour). The torbangun leaves ethanol extract were tested to antioxidant activity assay using DPPH, and á-glucosidase inhibitory effects was measured with a spectrophotometric method. The analysis of leaves revealed the presence of Carbamic acid, monoammonium salt (CAS) Ammonium carbamate (11.73%), Hexadecanoic acid (CAS) Palmitic acid (8.35%), I-Limonene (5.92%), Heptadecene-(8)- carbonic acid-(1) (4.76%), Oxacycloheptadec-8-en-2-one (CAS) Ambrettolide (4.70%). The analysis of stem revealed the presence of Formamide (CAS) Methanamide (22.48%), 12,13- Dimethyl-2,7- dioxa 5,10 diazatricyclo [4.4.4.0(1,6)] trans -tetradecan-12 (13.22%), Hexadecanoic acid (CAS) Palmitic acid (11.51%), 2-Propanone, 1-hydroxy- (CAS) Acetol (10.14%), 9-Octadecen-1-ol, (Z)- (CAS) cis-9-Octadecen-1-ol (7.09%). The analysis of roots revealed the presence of Methanamine, N-methyl- (CAS) Dimethylamine (28.45%), Acetic acid (CAS) Ethylic acid (9.78%), 3.2-Propanone, 1-hydroxy- (CAS) Acetol (6.41%), 1-Propen-2-ol, acetate (CAS) Isopropenyl acetate (5.16%), 4.73 Phenol, 2-methoxy- (CAS) Guaiacol(4.73%). The DPPH result of torbangun leaves ethanol extract obtained by IC50 247,942 ppm and ascorbic acid standard was 1 ppm. IC50 values inhibition of á-glucosidase extract was >100 ppm and glucobay standard was 0.264 ppm. This research provided a chemical compound and the torbangun leaves ethanol extract capable of acting as antioxidant based on IC50 values.Keywords: antioxidant activity, chemical compound, Coleus amboinicus LourABSTRAKPenelitian ini bertujuan untuk mengetahui komponen senyawa kimia dalam daun, dahan, dan akar menggunakan analisis Kromatografi Gas-Spektrometri Massa (GC-MS) serta aktivitas antioksidan daun torbangun (Coleus amboinicus Lour). Daun torbangun yang diekstrak etanol dianalisis aktivitas antioksidan menggunakan test DPPH, dan daya hambat enzim á-glukosidase diukur dengan metode spektrofotometer. Hasil analisis dalam daun menunjukkan komponen kimia Carbamic acid, monoammonium salt (CAS) Ammonium carbamate (11,73%), Hexadecanoic acid (CAS) Palmitic acid (8,35%), I-Limonene (5,92%), Heptadecene-(8)-carbonic acid-(1) (4,76%), Oxacycloheptadec-8-en-2-one (CAS) Ambrettolide (4,70%). Hasil analisis dalam dahan menunjukkan komponen kimia Formamide (CAS) Methanamide (22,8%), 12,13-Dimethyl-2,7-dioxa5,10diaza tricyclo [4.4.4.0(1,6)] trans-tetradecan-12 (13,22%), Hexadecanoic acid (CAS) Palmitic acid (11,51%), 2-Propanone,1-hydroxy-(CAS) Acetol (10,14%), 9-Octadecen-1-ol, (Z)- (CAS) cis-9-Octadecen-1-ol (7,09%). Hasil analisis dalam akar menunjukkan komponen kimia Methanamine, N-methyl-(CAS) Dimethylamine (28,45%), Acetic acid (CAS) Ethylic acid (9,78%), 3.2-Propanone, 1- hydroxy- (CAS) Acetol (6,41%), 1-Propen-2-ol, acetate (CAS) Isopropenyl acetate (5,16%), 4.73 Phenol, 2-methoxy- (CAS) Guaiacol (4,73%). Hasil uji antioksidan terhadap daun torbangun dengan metode DPPH didapatkan IC50 247,942 ppm dibandingkan standar vitamin C 1 ppm. Nilai IC50 dari penghambatan enzim á-glukosidase dalam ekstrak daun torbangun >100 ppm dibandingkan dengan standar glukobay 0,264 ppm. Hasil penelitian ini menunjukkan bahwa daun torbangun yang diekstrak dengan etanol mampu berperan sebagai antioksidan berdasarkan nilai IC50.Kata kunci: aktivitas antioksidan, Coleus amboinicus Lour, komponen kimia
Co-Authors Bombing Rombelayuk Allorante, Sealtiel Diani, Yusias Hikmat Ekowati Handharyani HERA MAHESHWARI Kusuma, Rini Anjarwati Marantuan, Randolph Serep MARIA BINTANG Pangaribuan, Achnes Rimbawan , Rizal M Damanik, Rizal M Siagian, Forman Erwin Sunarti, Lusia Sri Taneo, Putri Manuella Ussy Yang, John Jackson