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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Herni Suprapti
Bagian Farmakologi Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Pharmacogenomics Statins: Biomarkers for Clinical Prediction Herni Suprapti
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (759.993 KB) | DOI: 10.30742/jikw.v7i1.61

Abstract

Statins are the most widely prescribed drug for hyperlipidemic therapy and for the prevention of Cardiovascular disease. But although statins are very effective for the prevention of atherosclerosis, there are still patients with CVD. In this case, it is thought to be the influence of genetic factors. There is a static gene link to statin dose required for therapy, but there are still no relevant pharmacogenomic tests for statin therapy guidelines. This article describes basic pharmacogenomic terminology, genes (CETP, HMGCR, SLCO1B1, ABCB1, and CYP3A4 / 5), and progression of statin pharmacogenomic biomarkers for predicted therapeutic outcomes.
Interaksi obat Herni Suprapti
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 2, No 3 (2011): Volume Edisi Khusus Desember 2011
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4700.565 KB) | DOI: 10.30742/jikw.v2i3.2205

Abstract

Banyak pasien, terutama orang tua diperlakukan terus menerus dengan satu atau lebih obat untuk penyakit kronis seperti hipertensi, gagal jantung, osteoarthritis dan sebagainya.
Hubungan Kadar Low-Density Lipoprotein (LDL) dan Body Mass Index (BMI) terhadap Kejadian Stroke pada Pasien Lanjut Usia di RSUD Raden Tumenggung Notopuro Sidoarjo Tahun 2023 Balqis Agita Yuhasnara; Herni Suprapti; Nugroho Eka Wirawan Budianto
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 6 No. 1 (2026): Maret : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v6i1.8893

Abstract

This study aims to determine the relationship between Low-Density Lipoprotein (LDL) levels and Body Mass Index (BMI) with the incidence of stroke among elderly patients at Raden Tumenggung Notopuro Regional General Hospital, Sidoarjo, in 2023. This research employed a quantitative method with a case-control design, using secondary data obtained from patient medical records. The sampling technique used was non-probability sampling with a consecutive sampling approach, resulting in 112 respondents who met the inclusion and exclusion criteria. Data were analyzed using the Levene Test for homogeneity, the Mann-Whitney Test for comparison, and the Spearman correlation test. The results indicated a significant relationship between LDL and BMI with stroke incidence, with p-values of 0.000 and 0.003 (p<0.05), respectively. The correlation coefficients showed a strong positive relationship between LDL levels and stroke incidence (r=0.508), as well as a moderate positive relationship between BMI and stroke (r=0.276). It can be concluded that elevated LDL levels and imbalanced BMI contribute significantly to the increased risk of stroke among the elderly. Therefore, controlling cholesterol levels, maintaining a healthy diet, and monitoring body weight are essential preventive measures to reduce stroke risk in this population.
Co-Authors Balqis Agita Yuhasnara Nugroho Eka Wirawan Budianto