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All Journal Jurnal Kedokteran Brawijaya Jurnal Ilmiah Kedokteran Wijaya Kusuma
Herni Suprapti
Bagian Farmakologi Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Chromosome Aberration on Growth and Developmental Disorder Eva Diah Setijowati; Herni Suprapti; Maria Widijanti Sugeng; Retno Dwi Wulandari
Jurnal Kedokteran Brawijaya Vol. 32 No. 2 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.02.5

Abstract

Growth and development in humans begin at conception, which shows progress and interdependence. Normal children show the characteristic of growth and development. In children with growth and development disorder, chromosomal abnormality may be found. This study aimed to determine chromosomal abnormality in patients with growth and development disorder. The samples were taken from karyotype results of patients in the Medical Genetics Laboratory, Faculty of Medicine, Universitas Wijaya Kusuma Surabaya, from 2010-2020. The inclusion criteria were infants to adolescents aged 24 years and unmarried who experienced impaired growth and development, including sexual development. Chromosomal abnormalities were obtained from cytogenetic analysis using the G-banding method. From 75 samples with growth and development disorders, there were abnormalities in the number of autosomal chromosomes and sex chromosomes found in patients with Down syndrome, Turner syndrome, Klinefelter syndrome, and Edwards syndrome. Chromosomal structural abnormalities found were deletion, translocation, inversion, duplication, marker chromosome, and heteromorphism. This study showed the importance of karyotyping in children and adolescents with growth and developmental disorders.
Pharmacogenomics Statins: Biomarkers for Clinical Prediction Herni Suprapti
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (759.993 KB) | DOI: 10.30742/jikw.v7i1.61

Abstract

Statins are the most widely prescribed drug for hyperlipidemic therapy and for the prevention of Cardiovascular disease. But although statins are very effective for the prevention of atherosclerosis, there are still patients with CVD. In this case, it is thought to be the influence of genetic factors. There is a static gene link to statin dose required for therapy, but there are still no relevant pharmacogenomic tests for statin therapy guidelines. This article describes basic pharmacogenomic terminology, genes (CETP, HMGCR, SLCO1B1, ABCB1, and CYP3A4 / 5), and progression of statin pharmacogenomic biomarkers for predicted therapeutic outcomes.
Interaksi obat Herni Suprapti
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 2, No 3 (2011): Volume Edisi Khusus Desember 2011
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4700.565 KB) | DOI: 10.30742/jikw.v2i3.2205

Abstract

Banyak pasien, terutama orang tua diperlakukan terus menerus dengan satu atau lebih obat untuk penyakit kronis seperti hipertensi, gagal jantung, osteoarthritis dan sebagainya.
Co-Authors Eva Diah Setijowati Maria Widijanti Sugeng Wulandari, Retno Dwi