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All Journal Studia Economica: Jurnal Ekonomi Islam JSFK (Jurnal Sains Farmasi & Klinis)
Nahdiah Nahdiah, Nahdiah
STAIN Palangka Raya
Religion Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Studi In Silico dan Pengaruh Gugus Metoksi pada Hasil Sintesis Analog Kalkon terhadap Inhibisi Enzim α-Glukosidase Dona, Rahma; Furi, Mustika; Frimayanti, Neni; Zamri, Adel; Nahdiah, Nahdiah
JSFK (Jurnal Sains Farmasi & Klinis) Vol 9 No 1 (2022): J Sains Farm Klin 9(1), April 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.1.12-23.2022

Abstract

Kalkon (1,3-diaril-2-propen-1-on) merupakan golongan flavonoid yang memiliki banyak aktivitas salah satunya sebagai antidiabetes. Pada penelitian ini dilakukan sintesis tiga senyawa analog kalkon yaitu 2’-hidroksi-2-metoksi-kalkon (Kalkon1), 2’-hidroksi-3-metoksi-kalkon (Kalkon2) dan 2’-hidroksi-4-metoksi-kalkon (Kalkon3) dan serta dilakukan pengujian karakterisasi nya. Sintesis analog kalkon  dilakukan dengan metode irradiasi microwave menggunakan  katalis KOH, pelarut etanol dan PEG 400. Struktur setiap produk dikarakterisasi melalui spektroskopi UV-Vis, FTIR dan 1H NMR, menunjukkan bahwa ketiga senyawa analog kalkon hasil sintesis memiliki struktur sesuai dengan yang diharapkan, dengan hasil rendemen yaitu 91,53% (Kalkon1), 79,01% (Kalkon 2) dan 77,48% Kalkon 3. Berdasarkan studi in silico dari parameter nilai energi bebas ikatan didapatkan bahwa senyawa Kalkon 3 memiliki nilai energi bebas ikatan terkecil yaitu sebesar -8,8 kcal/mol dibandingkan senyawa Kalkon1 dan Kalkon2 yaitu sebesar -7,5 kcal/mol, -6,8 kcal/mol. Untuk  parameter  kecocokan asam amino dengan kontrol positif (akarbose), hanya senyawa Kalkon1 yang memiliki kecocokan dengan kontrol positif (akarbose) sedangkan untuk parameter ikatan hidrogen didapatkan bahwa semua senyawa uji tidak menunjukkan adanya interaksi berupa ikatan hidrogen antara ligand dan reseptor. Hasil ini menunjukkan senyawa Kalkon1, Kalkon 2 dan Kalkon 3 diperkirakan tidak aktif sebagai inhibitor enzim α-glukosidase.
Dampak Program Zakat Community Development (ZCD) Di Kelompok Penggemukan Sapi Ternak Mekar Samarinda Nahdiah, Nahdiah; Mursyid, Mursyid; Nasir, Muhammad
Studia Economica : Jurnal Ekonomi Islam STUDIA ECONOMICA: Jurnal Ekonomi Islam | Vol. 11 | No. 1 | 2025
Publisher : Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/se.v0i1.23210

Abstract

This study aims to trace the impact of the Zakat Community Development (ZCD) program run by BAZNAS East Kalimantan Province using a sustainable livelihood impact assessment (SLIA) which looks at 5 assets, namely natural assets, human assets, financial assets, social assets, and physical assets. This research uses a qualitative method using case studies. The data obtained from this study was through interviews and observations with BAZNAS employees of East Kalimantan Province and the Chairman of the Mekar Cattle Fattening Group as mustahik. The results of this study show that the management and utilization of natural assets in the Mekar Cattle Fattening Group has been carried out well and has an impact on the fertility of the surrounding environment. Likewise, the utilization of human, financial, social, and physical assets has increased from this group after receiving assistance from the zakat community development program, the increase in financial assets can be seen from the increase in cattle sales from this group, and the development of other businesses carried out by the group's members. The social asset is the contribution from the group to the community such as infaq, the contribution of road repairs in their area. The physical assets of this group can also be said to increase with the increase in the number of stables, besides that members of this group can also increase the ownership of personal belongings from the sale of cattle
Co-Authors Adel Zamri Furi, Mustika Mursyid, Mursyid Nasir, Muhammad Neni Frimayanti Rahma Dona