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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Riset Kimia Medical Laboratory Technology Journal Jurnal Penelitian Farmasi Indonesia Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JSFK (Jurnal Sains Farmasi & Klinis) JURNAL PHOTON JFL : Jurnal Farmasi Lampung Jurnal Ilmu Kefarmasian Indonesia Jurnal Midpro Jurnal Ilmiah Farmako Bahari International Journal of Health and Pharmaceutical (IJHP) Jurnal Farmasi Sains dan Praktis Jurnal Bakti Nusantara Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Rahma Dona
Sekolah Tinggi Ilmu Farmasi Riau
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Physics Public Health Other

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Uji sitotoksisitas dan antiproliferatif ekstrak etanol daun leunca (Solanum Nigrum,L) terhadap sel raji Dona, Rahma; Sulistyani, Nanik; Nurani, Laela Hayu
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (449.264 KB) | DOI: 10.12928/pharmaciana.v6i2.3506

Abstract

Leunca (Solanum nigrum,L.) is one of the medicinal plant which used society for traditional medication as antipyretic, hypotensive and anticancer. The aim of  this research was to know an anticancer activity of ethanol extract of leunca leaves, emphasized on an ability to inhibit the growth Raji cell. Ethanol extract took from leunca leaf powder that epitomized using ethanol solvent by Soxhlet instrument. Citotoxicity test was done by incubating Raji cell at a density of 2x104 with treatment using ethanol extract from leunca (Solanum nigrum L.) leaf in several concentration 500; 250; 125; 62,5; 31,25; 15,62; 7,81 and 3,90 µg/ml. A test was done by MTT method and the percent of cell mortality was calculated. The LC50 values were calculated using probit analysis. The research continued with antiproliferation test on treatment sample concentration 50; 25 µg/ml with cell control for 24, 48, and 72 hours.The result of research indicate that ethanol extract of leunca leaves had cytotoxic effect towards Raji cell with LC50 values 59,22 µg/ml. The result of  antiproliferation test showed that there were the growth of inhibitation on treatment sample with doubling time values 69,56 hour at concentration 50 µg/ml; 60,00 hour at concentration 25 µg/ml, and doubling time cell control is 44,98 hour.
SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KALKON TERSUBSTITUSI METOKSI Dona, Rahma; Zamri, Adel; Jasril, -
Sistem Informasi Vol 5 No 2 (2015): Jurnal Photon
Publisher : Fakultas MIPA dan Kesehatan Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (268.933 KB)

Abstract

tumbuhan dalam jumlah yang relatif sedikit. Senyawa ini merupakan prekursor untuk biosintesis flavonoid dan isoflavonoid. Senyawa kalkon telah dilaporkan memiliki berbagai aktivitas biologis yang menarik seperti antimikrob, antitumor, antioksidan, antiinflamasi, antimalaria, dan antikanker. Aktivitas senyawa kalkon dipengaruhi oleh gugus α,β-tak jenuh dan substituen yang terdapat pada cincin aromatiknya. Pada penelitian ini, tiga analog kalkon tersubstitusi mono-metoksi pada cincin A aromatik dan cincin B aromatiknya telah disintesis menggunakan metode iradiasi microwave dengan katalis KOH dan pelarut etanol. Struktur setiap produk dikarakterisasi dengan spektroskopi UV-Vis, FTIR, 1H NMR, 13C NMR, dan HRMS. Uji toksisitas dilakukan menggunakan metode Brine Shrimp Lethality Test (BSLT). Berdasarkan hasil uji BSLT, ketiga senyawa tersebut berpotensi sebagai senyawa antikanker dengan nilai LC50<200 μg/mL.
Uji sitotoksisitas dan antiproliferatif ekstrak etanol daun leunca (Solanum Nigrum,L) terhadap sel raji Rahma Dona; Nanik Sulistyani; Laela Hayu Nurani
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (500.224 KB) | DOI: 10.12928/pharmaciana.v6i2.3506

Abstract

Leunca (Solanum nigrum,L.) is one of the medicinal plant which used society for traditional medication as antipyretic, hypotensive and anticancer. The aim of  this research was to know an anticancer activity of ethanol extract of leunca leaves, emphasized on an ability to inhibit the growth Raji cell. Ethanol extract took from leunca leaf powder that epitomized using ethanol solvent by Soxhlet instrument. Citotoxicity test was done by incubating Raji cell at a density of 2x104 with treatment using ethanol extract from leunca (Solanum nigrum L.) leaf in several concentration 500; 250; 125; 62,5; 31,25; 15,62; 7,81 and 3,90 µg/ml. A test was done by MTT method and the percent of cell mortality was calculated. The LC50 values were calculated using probit analysis. The research continued with antiproliferation test on treatment sample concentration 50; 25 µg/ml with cell control for 24, 48, and 72 hours.The result of research indicate that ethanol extract of leunca leaves had cytotoxic effect towards Raji cell with LC50 values 59,22 µg/ml. The result of  antiproliferation test showed that there were the growth of inhibitation on treatment sample with doubling time values 69,56 hour at concentration 50 µg/ml; 60,00 hour at concentration 25 µg/ml, and doubling time cell control is 44,98 hour.
Penetapan Kadar Vitamin E dalam Ekstrak n-Heksan Buah Kelapa Sawit (Elaeis guineensis Jacq) dan CPO (Crude Palm Oil) dengan Metode KCKT Mustika Furi; Rahma Dona; Vincent Tristan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.915

Abstract

Palm fruit (Elaeis guineensis Jacq) is a natural source of vitamin E (tocopherol). This study has determined vitamin E levels in n-hexane extracts of palm fruit (Elaeis guineensis Jacq) and CPO (Crude Palm Oil) using HPLC (High Performance Liquid Chromatography) method. The subject were palm fruit and CPO obtained from plantations and palm fruit mills PT X located in Kampar district, Riau. Extraction of palm fruit and CPO using ultrasonication and saponification method. Measurement using HPLC obtained optimum conditions using mobile phase acetonitrile: water (86:14), flow 1 mL/minute, UV-Vis detector at wavelength 284 nm and obtained retention time is 3,488 minutes. Determination of the calibration curve is obtained the regression equation y = 702,872x + 3273,26 and r2 = 0,9985. The result of the determination vitamin E levels in the palm fruit extract and CPO sequentially is (469,4008 ± 2,5879) µg/mg and for CPO is (262,5248 ± 6,3987) µg/mg.
Studi In Silico, Sintesis, dan Uji Sitotoksik Senyawa P-Metoksi Kalkon terhadap Sel Kanker Payudara MCF-7 Rahma Dona; Neni Frimayanti; Ihsan Ikhtiarudin; Benni Iskandar; Fikri Maulana; Nova Tantri Silalahi
Jurnal Sains Farmasi & Klinis Vol 6, No 3 (2019): J Sains Farm Klin 6(3), Desember 2019
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (48.117 KB) | DOI: 10.25077/jsfk.6.3.243-249.2019

Abstract

Kalkon (1,3-difenil-2-propene-1-on) adalah salah satu senyawa golongan flavonoid yang memiliki beragam aktivitas biologis diantaranya sebagai antikanker. Penelitian ini bertujuan untuk mengetahui  efek sitotoksik analog kalkon (E)-3-(4-metoksifenil)-1-fenilprop-2-en-1-on dengan menggunakan teknik komputerisasi (docking), senyawa analog kalkon tersebut disintesis menggunakan reaksi kondensasi Claisen-Schmidt dengan katalis basa secara metode iradiasi gelombang mikro. Studi in silico ini dilakukan antara senyawa kalkon dengan  protein dengan kode PDB ID P521 dengan menggunakan program AutoDock Vina, sedangkan uji aktivitas sitotoksik senyawa kalkon dilakukan terhadap sel kanker payudara MCF-7 menggunakan metode WST-8. Berdasarkan hasil docking, senyawa kalkon (E)-3-(4-metoksifenil)-1-fenilprop-2-en-1-on memiliki potensi sebagai penghambat aktif terhadap sel kanker payudara MCF-7 ditandai dengan senyawa ini memiliki nilai energi bebas ikatan yang lebih kecil dibandingkan doxorubicin sebagai pembanding; memiliki 4 persamaan asam amino dengan doxorubicin dimana interaksi yang terbentuk terdiri dari 4 jenis ikatan yaitu ikatan hidrogen, ikatan van der Waals, ikatan pi-sigma dan ikatan pi –alkil.  Dari hasil uji sitotoksik antara sel kanker MCF-7 dan senyawa kalkon diperoleh nilai IC50 sebesar 48,18 µg/mL. Dari penelitian tersebut dapat disimpulkan bahwa senyawa analog kalkon (E)-3-(4-metoksifenil)-1-fenilprop-2-en-1-on dapat berpotensi sebagai inhibitor terhadap sel kanker payudara MCF-7
SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KALKON TERSUBSTITUSI METOKSI Rahma Dona; Adel Zamri; - Jasril
Sistem Informasi Vol 5 No 2 (2015): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v5i2.579

Abstract

tumbuhan dalam jumlah yang relatif sedikit. Senyawa ini merupakan prekursor untuk biosintesis flavonoid dan isoflavonoid. Senyawa kalkon telah dilaporkan memiliki berbagai aktivitas biologis yang menarik seperti antimikrob, antitumor, antioksidan, antiinflamasi, antimalaria, dan antikanker. Aktivitas senyawa kalkon dipengaruhi oleh gugus α,β-tak jenuh dan substituen yang terdapat pada cincin aromatiknya. Pada penelitian ini, tiga analog kalkon tersubstitusi mono-metoksi pada cincin A aromatik dan cincin B aromatiknya telah disintesis menggunakan metode iradiasi microwave dengan katalis KOH dan pelarut etanol. Struktur setiap produk dikarakterisasi dengan spektroskopi UV-Vis, FTIR, 1H NMR, 13C NMR, dan HRMS. Uji toksisitas dilakukan menggunakan metode Brine Shrimp Lethality Test (BSLT). Berdasarkan hasil uji BSLT, ketiga senyawa tersebut berpotensi sebagai senyawa antikanker dengan nilai LC50<200 μg/mL.
PENENTUAN KADAR TOTAL FENOLIK, TOTAL FLAVONOID DAN UJI AKTIVITAS ANTIOKSIDAN DARI EKSTRAK DAN FRAKSI DAUN KARAMUNTING (Rhodomyrtus tomentosa (Aiton) Hassk): antioxidant Rahma Dona
Jurnal Penelitian Farmasi Indonesia Vol. 9 No. 2 (2020): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v9i2.975

Abstract

Karamunting (Rhodomyrtus tomentosa (Aiton) Hassk) is a family of Myrtaceae which has been used by the community as traditional medicine. The purpose of this research is determine total phenolic and total flavonoid level and test antioxidant activity of Karamunting Leaves. Determination of total phenolic using gallic acid standard by the Folin Ciocalteu method. The results obtained total phenolic in water fraction of 99 mgGAE/g, ethanol extract 94,1 mgGAE/g, ethyl acetate fraction 83,3 mgGAE/g and n-hexane fraction 41,4 mgGAE/g. Determination of total flavonoid using standard quersetin with AlCL3 complex formation method, the results obtained total flavonoid in water fraction of 156,8 mgQE/g, ethanol extract 192,6 mgQE/g, ethyl acetate fraction 89,4 mgQE/g and n-hexane fraction 31,3 mgQE/g. Determination of antioxidant activity was determined by DPPH radical capture test (1,1-diphenyl-2-picrylhydrazyl), the results obtained in water fraction with IC50 value 15,02 µg/mL, ethanol extract 14,06 µg/mL, ethyl acetate fraction 14,48 µg/mL with very strong activity of antioxidant, whereas in the n-hexane fraction was categorized as weak antioxidant activity with an IC50 value of 264,02 µg/mL.
SINTESIS, KARAKTERISASI STRUKTUR, DAN KAJIAN MOLECULAR DOCKING SENYAWA 4’-METOKSI FLAVONOL SEBAGAI INHIBITOR MAIN PROTEASE (MPro) SARS-CoV-2 Ihsan Ikhtiarudin; Nesa Agistia; Neni Frimayanti; Enda Mora; Rahma Dona; Nofriyanti; Rosnita Dewi Rahmawati; Adel Zamri
Majalah Farmasi dan Farmakologi Vol. 26 No. 1 (2022): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v26i1.18652

Abstract

Main protease (MPro) merupakan salah satu protein yang memiliki peran penting dalam proses replikasi virus SARS-CoV-2. Beberapa studi in silico dan in vitro telah menunjukkan bahwa senyawa flavonoid baik alami maupun sintetis memiliki potensi yang menjanjikan untuk dikembangkan sebagai antivirus SARS-CoV-2. Penelitian ini bertujuan untuk mensintesis senyawa 4'-metoksi flavonol dan mengeksplorasi potensinya sebagai inhibitor MPro SARS-CoV-2. Sintesis dilakukan menggunakan senyawa awal 2'-hidroksi-4-metoksi kalkon melalui reaksi Algar-Flynn-Oyamada (AFO) dengan metode pengadukan (stirring method). Selanjutnya, kajian molecular docking dilakukan menggunakan struktur kristal MPro SARS-CoV-2 yang diunduh dari website RCSB Protein Data Bank (PDB ID: 6M2N). Hasil sintesis senyawa 4'-metoksi flavonol diperoleh rendemen produk sebesar 37,72 % dan struktur produk hasil sintesis telah dikonfirmasi melalui analisis spektroskopi UV-Vis, FT-IR, dan 1H NMR. Selanjutnya, hasil kajian molecular docking menunjukkan bahwa senyawa 4’-metoksi flavonol dapat membentuk ikatan hidrogen dengan dua residu penting pada sisi aktif 6M2N, yaitu Glu166 dan Gln189, dengan nilai energi bebas ikatan sebesar -7,13 kcal/mol dan nilai RMSD sebesar 1,45. Hasil kajian ini menunjukkan bahwa senyawa 4'-metoksi flavonol dapat terikat dengan lebih mudah pada sisi aktif MPro SARS-CoV-2 dibandingkan dengan baicalein sebagai senyawa flavonoid pembanding yang telah terbukti secara in vitro dapat menghambat aktivitas proteolitik MPro SARS-CoV-2.
Phytochemical Screening And Antioxidant Activity Testing Of Porang (Amorphophallus Muelleri Blume) Leaf Ethanol Extract From Kuta Buluh Region, North Sumatera Ainil Fithri Pulungan; Ridwanto Ridwanto; Gabena Indrayani Dalimunthe; Zulmai Rani; Rahma Dona; Ricky Andi Syahputra; Robiatun Rambe
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 1 (2022): February 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (192.501 KB) | DOI: 10.51601/ijhp.v3i1.141

Abstract

Porang (Amorphallus muelleri Blume) is one type of tuber plant that has the potential to be developed in Indonesia. Porang plants have been reported to contain chemical compounds that have antioxidant activity. This research was conducted on the leaves of the porang plant with the aim of knowing the antioxidant activity, characterization, and phytochemical profile of the compounds contained therein. Compound identification and characterization were performed using standard methods, and antioxidant activity was determined using the DPPH (1,1- Diphenyl-2-picrylhydrazyl ) method. The results of the identification of chemical compounds showed that the ethanol extract of porang leaves contained chemical compounds of alkaloids, flavonoids, tannins, saponins, and steroids. The results of the examination of the simplicia characterization of porang leaves included the soluble ethanol content of 33.93%, the water soluble extract content of 17.3%, the ash content of 5.58%, the acid insoluble ash content of 0.235% and the water content of 8%. From the results of the simplicia characterization, it shows that the results meet the specified requirements. The results showed that the ethanol extract of porang leaves had antioxidant activity with an IC50 value of 93.04 µg/mL, which in this case is included in the category of strong antioxidant activity. Meanwhile, as a comparison, Vitamin C was used, which has an IC50 value of µg/mL, which is included in the category of very strong antioxidant activity.
ALPHA-GLUCOSIDASE INHIBITORY ACTIVITIES OF KEDABU FRUIT (Sonneratia ovata BACKER) ETHANOL EXTRACT AND FRACTION Rahma Dona; Haiyul Fadhl; Mustika Furi; Tyasakti Viryana
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.4165

Abstract

One of the antidiabetic activity tests is carried out through inhibition testing of the ɑ-glucosidase enzyme. Sonneratia ovata Backer is a mangrove plant that has been used traditionally in medicine. The antidiabetic activity of the fruit samples of Kedabu (Sonneratia ovata Backer) was tested by measuring the inhibition of the ɑ-glucosidase enzyme in vitro. The test sample used ethanol extract (EE) and 3 fruit fractions of Kedabu. The calculation result of the IC50 value obtained at EE was 1.86 µg / mL, the calculation result of the IC50 value obtained in the n-hexane (FH) fraction of Kedabu fruit was 193.32 µg / mL, the calculation result of the IC50 value obtained in the ethyl acetate fraction (FE) of fruit Kedabu is 2.32 µg / mL and finally the calculation result of the IC50 value of water fraction (FA) is 2.29 µg / mL. The positive control in this study, Akarbose, obtained an IC50 result of 0.75 µg / mL. Based on the results obtained, the ethanol extract of Kedabu (Sonneratia ovata Backer) fruit is very active and has the potential as an inhibitor of the ɑ-glucosidase enzyme, followed by the water fraction and ethyl acetate fraction, while the potentially inactive sample is in the n-hexane fraction.
Co-Authors Abdi Wira Septama Abdi Wira Septama Adel Zamri Adel Zamri Adel Zamri Adel Zamri agistia, nesa Ainun Alfatma Anggraeni, Silvana Armon Fernando Armon Fernando Aulya, Nurliza BENNI ISKANDAR Dwi Andreyas Emma Susanti Emrizal Enda Mora Fikri Maulana Fikri Maulana, Fikri Fina Aryani, Fina Fithri Pulungan, Ainil Furi, Mustika Gabena Indrayani Dalimunthe Gressy Novita Haiyul Fadhli Hendra, Rudi Husnawati Ihsan Ikhtiarudin Jasril Jasril Jonang, Aqila Rifdah Kasnaidi, Ahmad Faisal Khairiah, Kinanti Bahy Laela Hayu Nurani Melzi Octaviani Milianty, Jesy Musyirna Rahmah Nst Muthui’ah Muthui’ah Nahdiah Nahdiah Nahdiah Nahdiah, Nahdiah Nanik Sulistyani Nasution, Musyirna Rahmah Neni Frimayanti Ningrum, Tilar Eka Widia Ningsih, Yozi Fiedya Nofriyanti Nova Novita Nova Tantri Silalahi Novita Sari Nurul Susianti Rahayu Utami Rahayu Utami Ricky Andi Syahputra Ridwanto Ridwanto Rizki Annisa A Robiatun Rambe Rosnita Dewi Rahmawati Sasnita, Nadya Ayu Selvia Selvia Septi Muharni Septiani Nindia Putri Silalahi, Nova Tantri Sinata, Novia Suci Anggela Soraya Syahbandi, Ilham Tyasakti Viryana utari, Mayang Vincent Tristan Winda Tria Safitri Wira Noviana Suhery YANTO YANTO Zulmai Rani