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All Journal Indonesian Journal of Rheumatology
Nadia Gita Ghassani
Lupus Study Group, Immunology Study Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia
Medicine & Pharmacology

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B-Cell Activating Factor Profile and Quality of Life in Systemic Lupus Erythematosus Patients Andri Reza Rahmadi; Habib Burahman; Nadia Gita Ghassani; Rachmat Gunadi Wachjudi; Laniyati Hamijoyo
Indonesian Journal of Rheumatology Vol. 14 No. 2 (2022): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v14i2.204

Abstract

Background: B-Cell Activating Factor (BAFF) is a cytokine that plays a role in systemic lupus erythematosus (SLE) pathogenesis. BAFF increases B cell function, which will affect disease activity. In addition to decreasing disease activity, good quality of life (QoL) is one of the goals to be achieved in SLE therapy, which is also affected by disease activity. The purpose of this study is to know the correlation of the BAFF profile with the QoL of SLE patients. Methods: This was a cross-sectional study using secondary data from a previous study. The subjects of this study were SLE patients who had visited the rheumatology outpatient clinic or were hospitalized in Hasan Sadikin Hospital Bandung from September 2016 until February 2017. Subjects were asked to complete the Short Form-36 and measure their BAFF level in serum. Demographic data were collected, and disease activity data were assessed by Mexican Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI). The statistical analysis used in this study was the Spearman test. Results: There was a positive correlation between BAFF and MEX-SLEDAI (r 0.238, p-value 0.038). There was also a negative correlation between MEX-SLEDAI and PCS, as well as the MCS score (r -0.392 and -0.371, p-value <0.05). Conclusion: BAFF levels will increase in higher disease activity which will affect a poorer quality of life.
Is Quality of Life of Lupus Better than Systemic Sclerosis? Laniyati Hamijoyo; Nadia Gita Ghassani; Bernard Santoso Suryajaya; Ignatius Irawan Hidayat; Valentine Natasya Moenadi; Sasfia Candrianita; Sumartini Dewi
Indonesian Journal of Rheumatology Vol. 11 No. 1 (2019): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v11i1.119

Abstract

Background. Patients with systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), have to cope with lifelong disease manifestation and impaired physical function. Limited physical activities along the disease will affect their quality of life (QoL). The QoL is recognized as an important factor of treatment strategy. This study aims to compare the quality of life of patient with SLE and SSc. Methods. This study was a cross-sectional study and conducted in rheumatology outpatient clinic of Hasan Sadikin Hospital Bandung, Indonesia from January 2015 until March 2017. The respondents were patients diagnosed as SLE and SSc who regularly visit rheumatology outpatient clinic. Respondents were asked to complete the Short Form-36 (SF-36). Baseline characteristics, including age, gender, and duration of disease, were collected during the visit. The Mann-Whitney U test was used to analyze the comparison. Results. There were 242 patients who completed the SF-36 questionnaires, consisted of 193 SLE patients and 49 SSc patients. SLE patients were slightly younger and had a longer duration of disease compared to SSc. The SF-36 Physical Component Summary (PCS) score was significantly higher on SLE patients (40.6 vs 40.4, p = 0.0001), but the mean of Mental Component Summary (MCS) score was similar among both diseases. Conclusion. Physical functioning aspect on quality of life is better in SLE patients compared to SSc patients. However, mental aspect for both diseases are relatively similar.
Co-Authors Andri Reza Rahmadi Bernard Santoso Suryajaya Habib Burahman Ignatius Irawan Hidayat Laniyati Hamijoyo, Laniyati Rachmat Gunadi Wachjudi Sasfia Candrianita Sumartini Dewi Valentine Natasya Moenadi