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All Journal Radioterapi & Onkologi Indonesia
Arie Munandar
Instalasi Pelayanan Terpadu Onkologi Radiasi, Fakultas Kedokteran Universitas Indonesia, RS. Dr. Cipto Mangunkusumo, Jakarta
Education Health Professions Medicine & Pharmacology Physics Other

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Role of Radiotherapy in Gestational Trophoblastic Neoplasia: A Case Report Arie Munandar; Viona Viona
Radioterapi & Onkologi Indonesia Vol 13, No 1 (2022): Volume 13 No.1 January 2022
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v13i1.143

Abstract

Gestational trophoblastic neoplasia (GTN) is a placental tissues malignancy that is prone to massive bleeding. Multimodality treatment is often needed to treat GTN, such as surgery and radiotherapy. Radiotherapy has a palliative role in case of hemorrhage and/or intracranial metastases.Radiotherapy is effective in controlling bleeding by destructing malignant blood vessels by inducing endothelial damage and increasing signal transduction pathway leading to apoptosis and increasing adhesion of thrombocytes to vascular endothelia resulting fibrosis. No dose and fractionation schemes are proven more effective than others, but longer fractions scheme (>5 fractions) and BED10 > 39 Gy show no additional benefit in hemostatic control or in reduction of re-bleeding rate.Brain metastatic lesions are prone to bleeding that might need craniotomy for blood evacuation or brain decompression. WBRT can be given concurrently with chemotherapy in brain metastatic GTN cases. Higher WBRT total dose (>22 Gy) associated with higher 5-year local control rates.
Co-Authors Viona Viona