The learning tool that will be developed is Student Worksheet oriented High Order Thinking (HOTS). Based on interviews with science subject teachers at research school used was student worksheet not HOTS-oriented, which was still Middle Order Thinking Skills level. This study aims (1) determine validity of student worksheets oriented HOTS on environmental pollution material, (2) describe practicality of student worksheets oriented HOTS on environmental pollution material, (3) describe effectiveness of student worksheets oriented HOTS on environmental pollution material developed. Research development with the Four-D development model developed by Thingarajan consists of 4 stages: define, design and develop. The results of the study were seen from percentage of each aspect obtained from 3 validators, namely validator I of 97%, validator II of 73% and validator III of 100% with very valid criteria. In addition, practicality of student worksheets oriented HOTS is seen from three stages, namely student activities (88.28%), learning implementation (100%), and student responses to student worksheets oriented HOTS (87%) with very good criteria. The effectiveness of student worksheets oriented HOTS states that the results of pretest and posttest carried out during learning show different results, namely the posttest is greater than pretest result using N-gain score % with value of 78 categorized as effective. Thus, student worksheets oriented HOTS is feasible and can be used in science learning about environmental pollution. Novelty this research is to produce student worksheets oriented HOTS on environmental pollution material. Benefits of research can foster creativity of students to think at higher levels independently.