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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Mandala Pharmacon Indonesia
Junvidya Heroweti
Universitas Wahid Hasyim
Medicine & Pharmacology

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Antiaging and Antiacne Activity of Ethanol-Methanol Extract of Mint Leaves (Mentha Piperita.) Risha Fillah Fithria; Junvidya Heroweti; Farah Fadiyah Anwar; Ihsannur Laily Safara; Anisatuz Zahro Atsabitah
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 19, No 2 (2022): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v19i2.6418

Abstract

ABSTRACT  Acne and premature aging are skin problems that are often experienced by Indonesian women. Mint leaves contain flavonoids which are known to be antibacterial and antioxidant. This study is an experimental study with pre and post test control group design that aims to determine the antibacterial activity of ethanol-methanol extract of mint leaves (EEMDM) against Propionibacterium acnes on the back of rabbits and antiaging activity on the hind limbs of rats. Mint leaves were extracted by maceration method using ethanol (70%) – methanol (1:1). Antiacne activity test using 5 rabbits induced by P.acnes intradermally on the back of shaved rabbits. The area was treated with K1 (clindamycin 0.1%), K2 (DMSO), C (EEMDM 30%), D (EEMDM 35%), E (EEMDM 40%). Antiaging activity test using 12 Wistar rats: 1 group as normal control (K1) and 5 test groups induced by UV light 311 nm and then treated with: C1 (EEMDM 20 mg/ml), C2 (EEMDM 40 mg/ml), C3 (EEMDM 60 mg/ml), C4 (EEMDM 80 mg/ml); and K2 (DMSO). The antiacne activity test parameter was a decrease in the diameter of the erythema. Tukey's Post Hoc test results showed that EEMDM concentrations of 30%, 35%, and 40% had antiacne activity. Antiaging test parameters in the form of decreased scores of wrinkles, erythema, and exfoliation. The results of the Kruskal Wallis test (p>0.05) showed that EEMDM concentrations of 20, 40, 60, and 80 mg/ml had no antiaging activity.keywords: antiacne, antiaging, ethanol-methanol, mint leaves 
Analisis Efektivitas Biaya Kombinasi CCB-ACEI dan CCB-ARB pada Pasien Hipertensi dengan Penyerta DM Tipe II Junvidya Heroweti; Indah Rokhmawati
Jurnal Mandala Pharmacon Indonesia Vol. 9 No. 1 (2023): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v9i1.311

Abstract

Hipertensi dan DM merupakan kasus kronis yang dialami oleh usia degeneratif. Kombinasi terapi antihipertensi jangka panjang membutuhkan biaya tinggi. Analisis diperlukan untuk mengetahui efektifitas terapi dari segi biaya dalam memberikan outcome yang paling baik. Penelitian ini bertujuan untuk menganalisis efektifitas biaya terapi kombinasi obat antihipertensi pada pasien BPJS dengan penyerta DM tipe II pada pasien rawat jalan di RSI NU Demak. Penelitian observasional dilakukan dengan pendekatan analisis farmakoekonomi menggunakan cost effectiveness analysis dengan menghitung nilai ACER dan ICER. Pengambilan data retrospektif menggunakan rekam medis dan melihat biaya medis langsung. Data dikelompokkan berdasarkan pola terapi kemudian dilakukan analisis efektivitas biaya pada setiap kelompok terapi. Analisis efektivitas biaya dilakukan dengan cara menghitung biaya medis langsung, efektivitas terapi berdasarkan target minimal tekanan darah, serta menghitung nilai ACER dan ICER. Hasil penelitian menunjukkan antihipertensi yang paling cost-effective berdasarkan ACER adalah kombinasi golongan CCB-ACEI, kombinasi Amlodipin 10 mg–Lisinopril 10 mg dengan nilai sebesar Rp.6.388,70. Nilai ICER didapatkan antihipertensi yang paling cost-effective yaitu kombinasi golongan CCB-ARB dengan terapi Amlodipin 5 mg–Valsartan 160 mg yang menunjukkan nilai sebesar  Rp. – 58.401,38. Analisis sensitivitas menunjukkan bahwa penggunaan CCB-ARB lebih sensitif terhadap kenaikan 25% biaya dibandingkan dengan kombinasi CCB-ACEI.
Evaluasi Penerapan Standar Pelayanan Farmasi Klinik Di Apotek Kabupaten Magelang Junvidya Heroweti; Fitri Rahmawati; Muhammad Ikhsan
Jurnal Ilmu Farmasi dan Farmasi Klinik 2023: [Special Edition] Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v0i1.9363

Abstract

Standar pelayanan farmasi (PMK 73/2016) menjadi tolak ukur pelayanan kefarmasian pada apotek meliputi compounding dan dispensing, pengkajian resep, konseling, pelayanan informasi obat, pelayanan kefarmasian di rumah, pemantauan terapi obat dan monitoring efek samping obat. Berdasarkan hasil observasi apotek di Kabupaten Magelang, terdapat beberapa apotek yang tidak terdapat apoteker selama apotek buka. Selain itu ditemukan juga tenaga kerja selain tenaga kefarmasian yang ikut serta dalam pelayanan farmasi klinik. Penelitian ini untuk mengevaluasi penerapan standar pelayanan farmasi klinik untuk apotek di sekitar Kabupaten Magelang. Penelitian dilakukan secara deskriptif non eksperimental dengan metode Cross-Sectional. Pemilihan sampel secara random dengan jumlah 25 apotek di wilayah Kabupaten Magelang. Pengambilan data menggunakan kuesioner. Data dianalisis dengan SPSS secara deskriptif kuantitatif. Evaluasi penerapan standar pelayanan farmasi klinik pada apotek di sekitar Kabupaten Magelang diperoleh hasil rata–rata pengkajian dan pelayanan resep  93,28%  (kategori baik), compounding dan dispensing 93,89% (kategori baik), pelayanan informasi obat 65,28% (kategori cukup), konseling 66,53% (kategori cukup), pemantauan terapi obat 45,37% (kategori kurang), dan monitoring efek samping obat 30,33 % (kategori kurang).
Sunscreen effectivity and physical characterization of avocado oil in nanoemulsion using isopropyl myristate variations Ayu Shabrina; Zuhriya Muna Firdausi; Agnes Theresya Poerba; Diana Anisa Setyani; Junvidya Heroweti
Pharmaciana Vol 14, No 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.28214

Abstract

Unsaturated fatty acids in avocado oil can help reduce erythema brought on by prolonged UV-B exposure. The effectivity of sunscreen absorption into the skin will be enhanced by the use of isopropyl myristate (IPM) in nanoemulsion. The purpose of this study was to determine the physical characteristics and sunscreen effectiveness of avocado oil nanoemulsion (AVN) modified with IPM. 1% (FI), 3% (FII), and 5% (FIII) IPM variation were used to make AVN with 5% oil. The AVN were tested for physical characteristics such as organoleptic, pH, viscosity, rheology, particle size and polydispersity index (PI). The products were also tested for sunscreen effectivity by in vitro and Minimum Erythemal Dose (MED) method. The data obtained were analyzed statistically. The results showed that the AVN was pale yellow and clear with transmittance percentage were 96%. The rheogram showed that the products were newtonian. The pH values range were from 6.62 to 6.66; viscosity 1.65-1.84 dPa.s; particle size < 17 nm, zeta potential was in range of -30,54±1,72 to -37,85±3,11 and PI < 0.5 for all formula. In vitro SPF values were 16.43 ± 4.50 (FI), 16.27 ± 4.20 (FII) and 17.88 ± 3.20 (FIII) (p >0.05), and categorized as ultra protection. MED value were 12.28 ± 1.34 (FI); 12.51 ± 1.68 (FII); and 13.22 ± 1.84 (FIII) (p< 0.05) and categorized as maximum protection. Isopropyl myristate increased the sunscreen product's MED value without changing its physical characteristics.
Co-Authors Agnes Theresya Poerba Anisatuz Zahro Atsabitah Ayu Shabrina Diana Anisa Setyani Farah Fadiyah Anwar Fitri Rahmawati Ihsannur Laily Safara Indah Rokhmawati Muhammad Ikhsan Risha Fillah Fithria Zuhriya Muna Firdausi