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All Journal JURNAL PROMOSI KESEHATAN INDONESIA Journal of Biomedicine and Translational Research
Riski Prihatningtias
Ophthalmology Department, Faculty of Medicine, Universitas Diponegoro
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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The Effect of Roselle Flower Infusion (Hibiscus sabdariffa) on Retinal Ganglion Cell Apoptosis of Sprague Dawley Rats Exposed to Cigarette Smoke Riski Prihatningtias; Puspita Kusuma Dewi; Desy Armalina; Hermawan Istiadi; Rahma Athifah Amelia; Faizah Fulyani
Journal of Biomedicine and Translational Research Vol 8, No 3 (2022): December 2022
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v8i3.15442

Abstract

Background: Cigarette smoke contains a lot of free radicals that can reduce antioxidants in the body. One of those is Reactive Oxygen Species (ROS) which can induce Retinal Ganglion Cell (RGC) apoptosis. Reduced ganglion cell axons will eventually lead to optic neuropathy. Supplementing herbal medicines, vitamins, foods, and drinks containing antioxidants is one way to increase oxidant levels in the body. Roselle or Hibiscus sabdariffa is a herbal plant reported to have a lot of antioxidant content.Objective: The study aimed to prove that Roselle flower infusions can reduce retinal ganglion cell apoptosis of Sprague Dawley rats exposed to cigarette smoke.Methods: This was an experimental study with a post-test-only design with a total of 24 male Sprague Dawley rats exposed to four non-filtered cigarettes/day for 30 consecutive days. They were randomly divided into four sub-groups, and each group consisted of 6 rats. The control group received 1 ml of saline, and three treatment groups received Roselle flower infusions of 2.5%, 5%, and 10% for 30 days. Enucleated eyes were then made paraffin blocks and slides with HE staining. The retinal ganglion cell apoptosis score was assessed by calculating the number of apoptotic cells using 1000x in five fields of view. The data were analyzed using Kruskal-Wallis non-parametric test followed by the Mann-Whitney U test.Results: The average retinal ganglion cell apoptosis score in control, treatment 1, 2, and 3 groups were 3.00; 2.83; 2.00; 1.83. There was a significant difference between the control group and treatment groups 2 (p=0.001) and group 3 (p=0.001), while between the control group and treatment group 1, there was no significant difference (p=0.317).Conclusion: The administration of 5% and 10% Roselle flower infusions can reduce the apoptosis score of retinal ganglion cells in Sprague Dawley rats exposed to cigarette smoke. The higher the Roselle flower infusion concentration, the lower the apoptosis score of retinal ganglion cells.
Sleep Quality and Screen Time as The Most Influential Factor of Computer Vision Syndrome Farhana Dhafira; Riski Prihatningtias; Trilaksana Nugroho; Maharani Maharani
Jurnal Promosi Kesehatan Indonesia Volume 18 No.2 Agustus 2023
Publisher : Master Program of Health Promotion Faculty of Public Health Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jpki.18.2.73-78

Abstract

Background: Since the Covid-19 Pandemic hit Indonesia, college students have had many eye health complaints; one is Computer Vision Syndrome (CVS). Factors that can increase the risk of CVS are decreased sleep quality, high computer/laptop use duration, and a non-ergonomic position. This study aimed to prove the relationship between sleep quality, visibility, and screen time on the incidence of CVS in medical students of Diponegoro University.Method: This cross-sectional study, including 147 medical students was conducted using primary data from questionnaires of Wendy Strouse Watt, Thomas H Murphy, Hospitality Eye Care Center, and vsp.com to gain data on respondent identity, visibility, and screen time. Sleep quality data were taken from the PSQI and CVS data through the CVS-Q questionnaire. Chi-square, Mann-Whittney, and logistic regression of multivariate analysis were used to analyze the data.Results: From 147 subjects, 108 were CVS (73.5%), and 39 were Non-CVS (26.5%). Variables of sleep quality and screen time (total) showed a significant relationship with CVS, which had p-values of p=0.001 and p=0.009 (p<0.05). As for the visibility to CVS, there was no relationship with p=0.863. In the multivariate test, sleep quality (p=0.000; ExpB=4.342) and total screen time (p=0.006; ExpB=3.913) were the most influential variables. The results showed that Computer Vision Syndrome is ubiquitous among Diponegoro University's final-year medical students. Sleep quality and total screen time can increase the risk of CVS by four times. This study also shows that CVS still appears in the post-pandemic era.
Co-Authors Desy Armalina Faizah Fulyani Farhana Dhafira Hermawan Istiadi Maharani Maharani Puspita Kusuma Dewi Rahma Athifah Amelia Trilaksana Nugroho