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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN e-GIGI JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Masyarakat Jaringan Laboratorium Medis Medica Arteriana (Med-Art) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Desy Armalina
Department Of Anatomy And Histology, Faculty Of Medicine, Universitas Diponegoro, Semarang, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Screening for Hypertension and Electrocardiography (ECG) for Cardiovascular Diseases Risk Armalina, Desy; Witjahjo, Bambang; Susilaningsih, Neni; Purnawati, Ratna Damma; Ismail, Akhmad; Saktini, Fanti
KEMAS: Jurnal Kesehatan Masyarakat Vol 15, No 3 (2020)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v15i3.17969

Abstract

ECG is a routine, accessible, inexpensive, and non-invasive tool for diagnosis of CVD and has been commonly described in medical reports as a suitable diagnostic tool for assessing ‘silent’ heart disease. An observational descriptive study, in Gisikdrono Urban Communities, found 72% elderly with hypertension, and higher than the reported national prevalence in 2013 (25.8%). We gained 38% of elderly with abnormal ECG which is: 5% Old myocardial infarction, 3% IMO Anteroseptal, 5% LVH, 8% LAD, 3%) of Inferior Ischemia, 3% dysrhythmia, and 13% bradycardia, without complaint of heart disease before. Aging became one of the factors of declining protection in the heart and increases the risk of destruction of heart failure. Considering examination of other organs that can affect the cause of heart anomalies to the elderly and expected to raise awareness of the importance of maintaining the blood pressure.
Pengaruh Konsentrasi Ekstrak Kulit Buah Naga Merah terhadap Pertum-buhan Streptococcus mutans pada Sediaan Obat Kumur (Uji Invitro) Ariyani, Bitha; Armalina, Desy; Purbaningrum, Diah A.
e-GiGi Vol 9, No 2 (2021): e-GiGi
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/eg.v9i2.34572

Abstract

Abstract: Caries could be minimized by reducing plaque accumulation with an antiseptic mouthwash. However, chlorhexidine 0,2%, the gold standard mouthwash, is known to have side effects. This has led to the innovation of an alternative herbal-based mouthwash that has antibacterial properties; one of the possible natural material is red dragon fruit peels. This study was aimed to prove the effect of red dragon fruit peel extract as mouthwash prepared in several concentrations to inhibit the growth of Streptococcus mutans. This was a quasi-experimental study with the post test control group design. There were six sample groups, namely mouthwash with extract concentration of 6.25%, 12.5%, 25%, and 50%, negative control (aquadest), and positive control (chlorhexidine 0.2%). The antibacterial assessment was done by using the well diffusion method calculating the inhibition zone formed around the wellbore. Data were analyzed by using the Kruskal Wallis test and the Mann Whitney Post Hoc test. The results showed that the average inhibition zones formed by extract mouthwash of 6.25%, 12.5%, 25%, 50% were 3.18 mm, 5.13 mm, 7.30 mm, and 11.01 mm respectively, and by positive control was 14.65 mm. There were significant differences between each treatment group. All concentrations of red dragon fruit peel extract in mouthwash could inhibit effectively the growth of Streptococcus mutans although not as effective as the positive control. In conclusion, red dragon fruit peel extract mouthwash could inihibit the growth of Streptococcus mutans.Keywords: mouthwash; red dragon fruit peel; Streptococcus mutans; antibacterial effect  Abstrak: Karies dapat diminimalisasi dengan mengurangi akumulasi plak menggunakan obat kumur antiseptik. Obat kumur chlorhexidine 0,2% merupakan obat kumur baku emas namun memiliki efek samping. Hal tersebut memunculkan inovasi untuk mencari alternatif obat kumur berbahan dasar herbal yang memiliki sifat antibakteri; salah satunya ialah kulit buah naga merah. Penelitian ini bertujuan membuktikan pengaruh ekstrak kulit buah naga merah dalam obat kumur dengan beberapa konsentrasi untuk menghambat pertumbuhan Streptococcus mutans penyebab karies. Jenis penelitian ialah quasi experimental dengan desain post test only group control design. Terdapat enam kelompok sampel yaitu obat kumur konsentrasi ekstrak 6,25%, 12,5%, 25%, 50%, kontrol (-) akuades, dan kontrol (+) chlorhexidine 0,2%. Uji antibakteri menggunakan metode difusi sumuran dengan menghitung zona hambat yang terbentuk di sekitar lubang sumuran. Uji statistik menggunakan Kruskal Wallis  dan uji post hoc Mann Whitney. Hasil penelitian mendapatkan rerata zona hambat yang terbentuk dari obat kumur konsentrasi ekstrak 6,25%, 12,5%, 25%, 50% ialah 3,18 mm, 5,13 mm, 7,30 mm, 11,01mm, dan kelompok kontrol(+) ialah 14,56 mm. Perbedaan bermakna terdapat pada setiap kelompok perlakuan. Setiap konsentrasi ekstrak kulit buah naga merah dalam obat kumur berpengaruh menghambat pertumbuhan bakteri Streptococcus mutans, namun belum sebaik kontrol (+). Simpulan penelitian ini ialah ekstrak kulit buah naga merah dalam obat kumur berpengaruh menghambat pertumbuhan bakteri Streptococcus mutans.Kata kunci: obat kumur; kulit buah naga merah; Streptococcus mutans; efek antibakteri
Effect of kelor (Moringa oleifera Lam) ethanolic leaves extract on uterus of pregnant mice and its teratogenicity Desy Armalina; Neni Susilaningsih; Indah Saraswati; Eva Annisa
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 4 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005304202102

Abstract

Moringa oleifera Lam (Moringaceae) is a source of additional dietary. It contains 9 essential amino acids, calcium, iron, potassium, magnesium, zinc and vitamins A, C, E and B which have a major role in the immune system. Previous study reported that M. oleifera Lam can increase the hemoglobin of breastfeeding mothers. In contrast, M. oleifera Lam is well known as abortifacient plant, therefore it is not recommended to use during pregnancy. The aim of this study was to evaluate the effect of M. oleifera Lam ethanolic leaves extract M. oleifera Lam on uterus of pregnant mice and its teratogenic effect. Twenty pregnant female Balb/c mice were used in this experimental study. Mice were randomized divided into four groups with five mice in each group. Group C as control, mice were not given anything. Group T1-T3 were given M. oleifera Lam ethanolic leaves extract during pregnancy age 7-18 days with doses of 10, 20 and 30 mg/kg BW, respectively.  Phytochemical analysis was performed quantitatively and qualitatively. On day 19, a caesarean section was performed to take the uterus, count the number of living foetus, dead foetus, disability, and other morphological abnormalities. No significant difference between all groups was observed. The abortifacient effect was not also observed in the uterus. Qualitative phytochemical analysis results showed that alkaloids, flavonoids, phenols, steroids, and tannins are identified in this extract. Quantitative steroids analysis results showed that the extract contained steroids of 1057.6 ppm. In conclusion, the M. oleifera Lam ethanolic leaves extract at dose of 30 mg/kg BW does not show any effect on the uterus of pregnant mice. Further study concerning the effects on other organs and hormones is recommended.
EFFECT OF DIFFERENT CONCENTRATION CINNAMON EXTRACTS (CINNAMOMUM BURMANNII) IN GROWTH LACTOBACILLUS ACIDOPHILUS (IN VITRO) Sherlin Mentary Farizha; Desy Armalina; Diah Ajeng Purbaningrum
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 1 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i1.30523

Abstract

Background: One of the dental and oral health problem that really need attention is caries. Lactobacillus acidophilus is one of the bacteria that play a role in the process of further caries in dentin. We can control it by using materials like antibacterial. Cinnamon barks (Cinnamomum burmannii) is a plant from Indonesia that contains antibacterial compounds such as sinamaldehid, flavonoid, tannins, alkaloids, and saponinsPurpose: To know the effect of various concentrations of cinnamon barks extracts (Cinamomum burmannii) on the growth of Lactobacillus acidophilus in vitroMethod: True experimental study with the post test control group design has 25 samples. Cinnamon barks was extracted by the soxhletation method then phytochemical tests were performed to determine the antibacterial compounds. Antibacterial tested using the diffusion method to determine the diameter of the inhibitory zone. Statistical tests using Kruskal-Wallis and Man-WhitneyResult: The mean inhibition zone diameters at concentrations of 6.25%, 12.5%, 25%, 50%, and positive controls were 4.80 mm, 10.99 mm, 16.83 mm, 19.14 mm, 29, 80 mm. Kruskal Wallis test showed significant differences in inhibition zone diameter in inhibiting the growth of Lactobacillus acidophilus p = 0,000321 (p <0.05). The Man Whitnney test showed a significant difference between the concentration of 6.25% with concentrations of 25% and 50% and concentrations of 12.5% with concentrations of 25% and 50%. There were no significant differences between the concentrations of 6.25% with 12.5% and 25 % with 50%Conclusion: There is an effect of cinnamon bark extracts from various concentrations on the growth of Lactobacillus acidophillus as assessed by the formation of inhibition zone diameters. The 25% concentration is the minimum concentration that can significantly inhibit bacteria
Histopathological changes in liver, kidney and teratogenic effects of mice on exposure to mosquito repellent Desy Armalina; Bambang Witjahjo; Neni Susilaningsih
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 1, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss1.art4

Abstract

Background: Mosquito repellent technology has changed from conventional technology to electric technology, which is more secure and practical. All insect repellent contains chemical compounds that can endanger health. D-Allethrin, the first pyrethroid generation of mosquito repellent is used commercially. Some studies in multi-ethnic population found transplacental transmission in pregnancy. Objective: This study aims to evaluate influences of D-Allethrin in mosquito repellent on liver and kidney, and teratogenic effects in foetal mice. Methods: An experimental laboratory design was conducted in 18 pregnant female Balb/c mice. They were randomized into 3 groups: Group K, P1 and P2. Group K was not given anything. Group P1 and P2 were given exposure pathways of mosquito repellent with inhalation for 12 and 24 hours, in a period of gestational age (0-18 days). On day 19, a Cesar surgery was conducted to take their foetuses and to count the number of living foetuses, dead foetuses, disability, and morphological abnormalities. Results: The administration of allethrin inhalation with dose 12 hours and 24 hours significantly damage mice’s kidney and liver microscopically (p<0.05). A microscopic result of the liver were necrosis in portal areas, hydropic degeneration of lobules, infiltration of inflammatory cells, and fibrosis in the portal area causing a sinusoidal portal to widen. Kidney examination obtained necrosis and hydropic degeneration, as well as the infiltration of lymphocytes and erythrocytes. Teratogenic effects in the foetuses were prematurity and failure of foetal development.Conclusion: Exposure pathways of D-Allethrin in mosquito repellent affected the microscopic appearance of the liver, kidney, and teratogenic effects in the foetuses.
Acute Toxicity Test of Soursop Leaves (Annona muricata) on Liver and Kidney of Switzerland Mice Utomo, Astika Widy; Susilaningsih, Neni; Armalina, Desy
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 6, No 2 (2015): July-December 2015
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (682.764 KB) | DOI: 10.30659/sainsmed.v6i2.600

Abstract

Introduction: The soursoup leaves extract (Annona muricata) has widely been used as traditional medicine for cancer. No studies have been conduct to investigate the safety of the extract. Objectives: The purpose of the study was to investigate the acute oral toxicity test of soursoup leaves extract (Annona muricata) on Swiss mice’s liver and kidney.Methods: Twenty four mice were divided into 4 groups. Group I was control group, while group II-IV was given soursoup leaves extract as single dose orally via sonde. The mice were obsereved until day 7 to determine the LD50 and at the end were terminated to collect the liver and kidney. The organs later were made into histopathology slides. The slides read with light microscope. The data analyzed with ANOVA and was considered significant at p<0.05.Results: All mice were alive during the 7 days observation and no mice showing the toxic spectrum after the dosing. Microscopically, no damage on the liver and kidney organ among the groups.Conclusion: The LD50 of soursoup leaves extract is more than 2000 mg/kgBW. This result indicate that the extract is practically non toxic and do not damage the liver and kidney.
The use of herbal medicines in patients with type-2 diabetes mellitus in Indonesia Utomo, Astika Widy; Annisaa, Eva; Antari, Arlita Leniseptaria; Armalina, Desy
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2022): June 2022
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (866.994 KB) | DOI: 10.30659/sainsmed.v13i1.13487

Abstract

In Indonesia, the use of herbal medicine as an alternative medicine is increasing. Herbal remedies are used as complementary medicine and self-medication. Diabetes mellitus requires treatment over the long term. This may contribute to the medication adherence problem. Consequently, many patients seek alternative treatments, such as herbal medications. The purpose of this study was to determine the use and type of herbal medicines among diabetic patients in Indonesia. A cross-sectional study with 190 respondents selected at random from multiple cities in Indonesia. A questionnaire was used to determine the most frequently used herbal medicine, the demographic profile of the patients, the health services, and the level of patient satisfaction with the use of herbal medicines. The participants were predominantly female (62.7%), housewives (39.5%), aged between 40 and 65 (84.5%), high school graduates (74.7%), and had low to moderate incomes (74.7%). The use of herbal medicine was 22%, and the combination of herbal medicine and prescription medication was 6%. Bitter leaves (10%), mangosteen peel (8.9%), insulin leaves (7.9%), mahkota dewa herbs (6.3%), and bitter melon are used as herbal or traditional medicines (4.7%). In terms of satisfaction, 28.7%, 40.9%, and 14.4% of respondents were quite satisfied, satisfied, and very satisfied with the use of herbal medicines, respectively. Herbal remedies are commonly used in alternative diabetes treatments. Bitter leaves are the most frequently used herb, with over half of respondents expressing satisfaction with the benefits of herbal medicine.
The Effect of Moringa oleifera Extract on Histopathological of Mice Testes Exposed by Monosodium Glutamate Handoyo, Regenio Akira; Saraswati, Indah; Mochtar, Arufiadi Anityo; Armalina, Desy; Miranti, Ika Pawitra
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 6 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i6.37311

Abstract

Background: Monosodium glutamate (MSG) consumption in excess can have an impact on a man's fertility and lead to infertility. MSG has the potential to produce free radicals, which can harm cells. Antioxidants can fight off free radicals. Exogenous antioxidants are required to maintain equilibrium since there will be an imbalance if the body produces more free radicals than endogenous antioxidants. Exogenous antioxidants flavonoids are present in the leaves of the Moringa plant (Moringa oleifera L). It is thought that flavonoids have 4-5 times more antioxidant potential than vitamins. Objectives: To evaluate how moringa leaf extract affects the histopathological profile of MSG-exposed mouse testes. Methods: Only the posttest was used as a control group in this study. 25 male mice were used as the sample, and they were split up into five groups. The treatment group 1 (P1) received 6 g/day of MSG exposure + 300 mg/kg BW/day of moringa leaf extract, the treatment group 2 (P2) received 6 g/day of MSG exposure + 600 mg/kg BW/day of moringa leaf extract, and the treatment group 3 (P3) received 6 g/day of MSG exposure + 1200 mg/kg BW/day of moringa leaf extract. The control group (K-) received only standard feed. The mice were put to death after 30 days. The testes were removed for histological examination using hematoxylin-eosin staining, and the Johnsen scoring criteria were applied to their evaluation. Results: The data were not significant according to the Shapiro-Wilk test in the P3 group (MSG 6 g/day + Moringa Extract 1200 mg/kg BW/day). The Kruskal-Wallis test revealed that there was no significant difference between the seminiferous tubules according to the treatment group (p = 0.117). Conclusion: Moringa oleifera leaf extract protects the histopathological picture of the testes of male mice compared to the group given monosodium glutamate. 
Appropriate Slice for Microscopic of Hepar and Kidney Mice Fixed With BNF 10% Armalina, Desy; Elen, Mircha Restiana; Labai, Nikita Ferren
Medica Arteriana (Med-Art) Vol 6, No 2 (2024): Desember 2024
Publisher : University of Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/medart.6.2.2024.43-49

Abstract

Background: Histological processing encompasses the steps of acquiring fresh tissue, preserving it through fixation to maintain its natural appearance, slicing it into thin sections, placing the sections on glass slides, and subsequently staining them. This enables the observation of various histological components within the tissue using a microscope. The objective of this study was to ascertain the microscopic characteristics of heparin preparations and the kidneys of mice (Mus musculus) through fixation using a formalin buffer solution.Method: This kind of research encompasses experimental research. The study employed a purposive sample methodology in its research design. This study concludes that preparations containing images provide a representative depic-tion of the cell nucleus, cytoplasm, and exhibit consistent coloration with different cutting thicknesses. The standard thickness for cutting the mice hepatic tissue using a microtome is 5 μm.Result: This thickness yields good microscopic results overall, with 25 field views from 5 preparations. The percentage of high-quality microscopic images obtained at this thickness is 100%. The statistical analysis revealed significant differences (p<0.05) between the 2 μm and 5 μm groups, as well as between the 5 μm and 8 μm groups. There was no statistically significant difference (p>0.05) observed between the 2 μm and 8 μm groups in terms of many aspects including structural, nucleolus, cytoplasm, color uniformity, and total structure scores.Conclusion: The optimum thickness in this research was 5 μm. Additional investigation is required to examine the microscopic characteristics of tissue samples by varying the duration of staining on the samples.
Histopathological changes in pregnant mice's hepar and kidney following exposure to kelor (Moringa oleifera) leaf extract Armalina, Desy; Susilaningsih, Neni; Saraswati, Indah
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 13, No 2 (2025): June
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.13.2.145-151

Abstract

Background: Moringa provides extra dietary benefits. The immune system is significantly influenced by the nine necessary amino acids, calcium, iron, potassium, magnesium, zinc, and vitamins A, C, E, and B that are included in this food. Previous studies state that moringa causes liver and kidney damage. Another study found that moringa has an abortive effect.Objectives: This study aimed to determine how exposure to kelor (moringa oleifera) leaf extract affected the hepar and kidney in pregnant mice and found the secondary metabolite of the moringa leaves.Materials and Methods: An experimental laboratory design was conducted in 24 pregnant female Balb/c mice. They were randomized into four groups. Group K was not given anything. Group P1-P3 were given moringa leaf extract during pregnancy at days with a dose dose of 10, 20, and 30 mg in 10, 20, and 18 days, and termination was done to take the organs and make the tissue processing.Results: We found no dead mice and no aggression during the experiment. Significant statistics differed between the experimental group in the microscopic appearance of the kidney and hepar. This study found degeneration and inflammation in the hepar and kidney in the treatment group. Qualitative phytochemical tests on leaves contained alkaloids, flavonoids, phenolics, tannins, and steroids.Conclusion: The ethanol extract of Moringa leaf has shown a mild heparin and kidney effect compared to the control.
Co-Authors Akhmad Ismail Antari, Arlita Leniseptaria Ariyani, Bitha Astika Widy Utomo, Astika Widy Bambang Witjahjo Bambang Witjahjo dewi, nasywa laksita Diah Ajeng Purbaningrum Elen, Mircha Restiana Eva Annisa Eva Annisaa Fanti Saktini Handoyo, Regenio Akira Ika Pawitra Miranti Indah Saraswati Labai, Nikita Ferren Mochtar, Arufiadi Anityo Neni Susilaningsih Pratiwi, Ela Nur Purbaningrum, Diah A. Ratna Damma Purnawati Sherlin Mentary Farizha Surati Surati