Marselus Merung, Marselus
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Journal : e-CliniC

PROFIL PENDERITA TUMOR KELENJAR LIUR DI RSUP PROF. DR. R.D. KANDOU MANADO PERIODE JULI 2012-JUNI 2015 Iman, Wirawan; Merung, Marselus; Aschorijanto, Ainun
e-CliniC Vol 4, No 1 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.4.1.2016.10976

Abstract

Abstract: Salivary glands tumours are relatively rare to find. There is still no adequate data about the incidence of salivary gland tumours in Indonesia. The main objective of this research was to cognise the profile of salivary glands tumours patients in Prof. Dr. R.D. Kandou Central General Hospital Manado from July 2012 to June 2015. Methods used is descriptive retrospective. The results showed there are 37 patients with salivary gland(s) tumour(s). Male was 59,5% and female was 40,5%. By age groups found that <19 years for 2.7%, 19-30 years for 8,2%, 31-45 years for 21.6%, 46-60 years for 37,8%, >60 years for 29,7%. Based on the histopathological classification, pleomorphic adenoma for 56.8%, Whartin's tumor for 8.1%, myoepithelioma for 2,7%, basal cell adenoma for 2.7%, oncocytoma for 2.7%, cystadenoma for 5.4%, canalicular adenoma for 2.7%, mucoepidermoid carcinoma for 10.8%, adenocarcinoma for 5.4%, and acinic cell carcinoma for 2.7%. Based on the location of the tumours’ appearance, parotid gland for 83.8%, submandibular gland for 13.5%, minor salivary glands for 2.7%. Based by the incidences annually, first year for 21.6%, second year for 32.3%, and the third year for 46.1%.Conclusion: Males are more than females, most commonly found in the age group of 51-60 years, the most commonly benign tumour found is the pleomorphic adenoma, the most commonly found malign tumour is mucoepidermoid carcinoma, the most commonly location of the tumours’ appearance is the parotid gland. The salivary glands tumours continued to increase during the last three years.Suggestion: Still necessary to do further research about salivary glands tumours.Keywords: salivary glands tumours, age, gender, histopathology, location, profileAbstrak : Tumor kelenjar liur adalah tumor yang relatif sedikit dijumpai ditemukan. Belum ditemukan data yang lengkap tentang kejadian tumor kelenjar liur di Indonesia. Tujuan utama dari penelitian ini adalah untuk mengetahui profil penderita tumor kelenjar liur di RSUP Prof. Dr. R.D. Kandou Manado periode Juli 2012-Juni 2015. Metode penelitian yang digunakan adalah deskriptif retrospektif. Hasil penelitian memperlihatkan terdapat 37 penderita tumor kelenjar liur. Laki-laki sebanyak 59,5% dan perempuan 40,5%. Kelompok usia <16 tahun sebanyak 2,7%, 16-30 tahun sebanyak 8,1%, 31-45 tahun sebanyak 21,6%, 46-60 tahun sebanyak 37,8%, >60 tahun sebanyak 29,7%. Berdasarkan klasifikasi histopatologi jenis pleomorphic adenoma sebanyak 56,8%, Whartin’s tumor sebanyak 8,2%, myoepithelioma sebanyak 2,7%, basal cell adenoma sebanyak 2,7%, oncocytoma sebanyak 2,7%, cystadenoma sebanyak 5,4%, canalicular adenoma sebanyak 2,7%, mucoepidermoid carcinoma sebanyak 10,8%, adenocarcinoma sebanyak 5,4%, acinic cell carcinoma sebanyak 2,7%. Berdasarkan lokasi munculnya tumor, kelenjar parotis sebanyak 83,8%, kelenjar submandibula sebanyak 13,5%, kelenjar liur minor sebanyak 2,7%. Berdasarkan jumlah pertahunnya, tahun pertama sebanyak 21,6%, tahun kedua sebanyak 32,3%, dan tahun ketiga sebanyak 46,1%.Kesimpulan : Penderita laki-laki lebih banyak daripada perempuan, paling banyak ditemukan pada kelompok usia 46-60 tahun, tumor jinak yang paling banyak ditemukan adalah pleomorphic adenoma, tumor ganas yang paling banyak ditemukan adalah mucoepidermoid carcinoma, lokasi tersering munculnya tumor adalah kelenjar parotis. Penderita tumor kelenjar liur terus meningkat selama tiga tahun terakhir.Saran : Perlu dilakukan penelitian lebih lanjut tentang tumor kelenjar liurKata Kunci : tumor kelenjar liur, usia, jenis kelamin, histopatologi, lokasi, profil
Analisis Hubungan Ca 15-3 dan Respon Kemoterapi Neoadjuvan pada Pasien Kanker Payudara Stadium Lanjut Lokal Rusli, Lie V.; Merung, Marselus; Pontoh†, Victor; Manginstar, Christian; Hatibie, Mendy J.; Langi, F. L. Fredrik G.
e-CliniC Vol 9, No 2 (2021): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v9i2.34659

Abstract

Abstract: Neoadjuvant chemotherapy is one of the therapeutic modalities used in the management of locally advanced breast cancer. Therapeutic response can be objectively assessed with RECIST and Ca 15-3 could be used to monitor response to breast cancer (BC) treatment. This study was aimed to prove the relationship between Ca 15-3 and response to neoadjuvant chemotherapy in locally advanced BC. The study was carried out at the Departement of Surgery Prof. Dr. R. D. Kandou Hospital Manado using a single-arm pre-post trial. Each patient would be performed Ca 15-3 test and clinical assessment (RECIST) pre and post chemotherapy for two sessions. There were 11 BC patients with invasive ductal carcinoma.  The average age was 60 years old and the majority had anemia and lymphocytopenia. There was a decrease in Ca 15-3 in each patient by a baseline of 21.8 U/mL pre-treatment and a decrease in the lesion size by 30.3 mm using RECIST. The results showed that changes in RECIST and Ca 15-3 level were correlated with each unit change in RECIST was associated with a decrease in Ca 15-3 level by 0.03 units (p=0.019). In conclusion, there was a decrease in Ca 15-3 level in response to chemotherapy, followed by a decrease in RECIST. There was a relationship between Ca 15-3 level and chemotherapy response assessed with RECIST after the second chemotherapy.Keywords: Ca 15-3, chemotherapy response, neoadjuvant chemotherapy, RECIST, breast cancer  Abstrak: Kemoterapi neoadjuvan masih merupakan pilihan utama terapi untuk kanker payudara (KPD) stadium lanjut local. Respon suatu kemoterapi dapat dinilai secara objektif dengan RECIST dan Ca 15-3 dapat digunakan untuk memantau respon terhadap pengobatan KPD. Penelitian ini bertujuan untuk membuktikan hubungan antara Ca 15-3 dengan respon kemoterapi neoadjuvan RECIST pada pasien KPD stadium lanjut lokal. Penelitian dilaksanakan di Bagian Bedah RSUP Prof. Dr. R. D. Kandou, Manado dengan menggunakan single-arm pre-post trial. Setiap individu yang terlibat akan diperiksa kadar Ca 15-3, serta penilaian RECIST sebelum dan sesudah mereka menerima kemoterapi selama dua sesi. Hasil penelitian mendapatkan 11 pasien KPD dengan karsinoma duktal invasif. Rerata usia 60 tahun, umumnya dengan anemia dan limfositopenia. Terdapat penurunan Ca 15-3 pada tiap pasien sebesar awal 21,8 U/mL pra pengobatan dan penurunan lesi 30,3 mm saat dinilai menurut RECIST. Didapatkan bahwa perubahan RECIST dan Ca 15-3 memiliki keterkaitan dengan setiap unit perubahan RECIST berhubungan dengan penurunan kadar Ca 15-3 sebesar 0,03 unit (p=0,019). Simpulan penelitian ini ialah terdapat hubungan antara kadar Ca 15-3 dengan respon kemoterapi setelah kemoterapi siklus ke dua.Kata kunci: Ca 15-3; respon kemoterapi; neoadjuvan kemoterapi; RECIST; kanker payudara