Background: Covid-19 is a new beta-coronavirus that has a single-stranded positive sense RNA genome with a diameter of 65-125 nm. The spread of the corona virus can occur through droplets, transmission of aerosols released from the nose or mouth of an infected person when talking, coughing, or sneezing. Covid-19 is more likely to infect older people and people who have underlying chronic diseases such as diabetes. The current handling of COVID-19 is done by changing people's behavior to comply with the Covid-19 prevention protocol.Purpose: Knowing the relationship between knowledge about Covid-19 prevention and protocol compliance among patients people with diabetes mellitusMethod: Quantitative with analytic cross-sectional design. The population was patients with diabetes mellitus, the sample size was 73 people, the sampling technique used was purposive sampling. Analysis using chi square test.Results: Finding that 67.1% of people with diabetes mellitus had good knowledge and 57.5% were obedient in carrying out the covid-19 prevention protocol. The results of the analysis obtained p-value 0.030 (p<0.05).Conclusion: There is a relationship between knowledge and adherence to diabetes mellitus patients in carrying out the Covid-19 prevention protocol. Patients with diabetes mellitus should be able to apply the Covid-19 prevention protocol in accordance with the standards set by the government so that the risk of being exposed to the Covid-19 virus can be avoided.Keywords: Knowledge; Compliance; Covid-19; Health protocolPendahuluan: Covid-19 merupakan beta-corona virus baru yang memiliki genom RNA sense positif beruntai tunggal dengan diameter 65-125 nm. Penyebaran virus corona dapat terjadi melalui percikan droplet, transmisi aerosol yang dikeluarkan dari hidung atau mulut orang yang terinfeksi saat berbicara, batuk, atau bersin. Covid-19 lebih mudah menginfeksi orang yang berusia lanjut dan orang yang memiliki penyakit kronis yang mendasari seperti diabetes. Penanganan covid-19 saat ini dilakukan dengan mengubah perilaku masyarakat agar mematuhi protocol pencegahan covid-19.Tujuan: Mengetahui hubungan antara pengetahuan tentang pencegahan Covid-19 dengan kepatuhan protokol pada pasien penderita diabetes melitus.Metode: Penelitian kuantitatif, dengan desain analitik rancangan cross sectional. Populasinya penderita diabetes mellitus dengan besar sampel yang diambil sebanyak 73 orang, teknik pengambilan sampel menggunakan purposive sampling. Analisis menggunakan uji chi square.Hasil: Didapatkan bahwa bahwa 67,1% penderita diabetes mellitus memiliki pengetahuan baik dan 57,5% patuh dalam menjalankan protocol pencegahan covid-19. Hasil analisis didapatkan p-value 0,030 (p<0,05).Simpulan: Terdapat hubungan antara pengetahuan terhadap kepatuhan penderita diabetes mellitus dalam menjalankan protocol pencegahan covid-19. Bagi penderita penderita diabetes mellitus hendaknya dapat menerapkan protocol pencegahan covid-19 sesuai dengan standar yang telah ditetapkan oleh pemerintah sehingga resiko terpapar virus covid-19 dapat dihindari.