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All Journal Jurnal Biosilampari: Jurnal Biologi
Fadiatul Ainiah
Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry

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HISTOPATHOLOGICAL CONDITION OF MALE RAT LIVER INDUCED BY CONDENSED TANNIN EXTRACT OF BELUNTAS LEAVE Eko Susetyarini; Fadiatul Ainiah; Fendy Hardian Permana
Jurnal Biosilampari : Jurnal Biologi Vol 5 No 1 (2022): Biosilampari
Publisher : LP4MK STKIP PGRI Lubuklinggau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31540/biosilampari.v5i1.1537

Abstract

This study at to determine the changes in liver histology of male rats after induction of condensed tannin extract of Beluntas leaves with control doses, 0.4 ml/kgBW, 2 ml/kgBW, and 3 ml/kgBW. This study is an experimental study for 14 days involving 24 samples of male rats. Parameters of histological structure changes were assessed by the scoring system for normal hepatocyte cell condition, parenchymatous degeneration, hydropic degeneration, and necrosis. One Way Anova test obtained a p value< 0.001 which means there was a significant difference in changes in the histopathological structure of liver cells significantly. Based on the Post Hoc test, it was obtained. between the control and treatment groups showed a significant difference between the control dose of 0.4 ml/kgBW, 2 ml/KgBW dose, and 3ml/KgBW dose. Meanwhile, the changes in liver histopathology between 2 ml/KgBW, and a dose of 3ml/KgBW were significantly the same.
Co-Authors Eko Susetyarini Fendy Hardian Permana