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All Journal Pro-Life Indonesian Journal of Applied Research (IJAR)
John Jackson Yang
Departeman Biokimia Kedokteran Fakultas Kedokteran, Universitas Kristen Indonesia, Jakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Immunology & microbiology

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Potensi Antijamur Ekstrak Andaliman (Zanthoxylum acanthopodium) terhadap Candida albicans Fri Rahmawati; John Jackson Yang; Irene Rumiris Bavelina
Jurnal Pro-Life Vol. 9 No. 3 (2022): November
Publisher : Program Studi Pendidikan Biologi Fakultas Keguruan dan Ilmu Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/jpvol6Iss2pp102

Abstract

Andaliman (Zanthoxylum acanthopodium DC) is a plant that grows and is widely used in Sumatra, especially by the Batak tribe (North Sumatra). Andaliman is empirically used for the treatment of diarrhea, toothache, and is a natural food preservative. Resistance increase of antifungal drugs to Candida albicans, so research is needed to find new ingredients that are effective as antifungals. The use of traditional medicines derived from plants can be an alternative for the community as an antifungal. The aim of the research was to determine the class of active compounds and the potential of andaliman fruit extract to inhibit the growth of C. albicans. The extraction process uses the maceration method with 70% ethanol and aquadest as a solvent. The antifungal activity test method used was the disc diffusion method and the phytochemical test using the Harborne method. The concentration of andaliman extract used was 50%, 40%, 30%, 20% and 10%, positive control was fluconazole and negative control was distilled water. The results showed that the andaliman extract was able to inhibit the growth of C. albicans with the lowest concentration of 10%. Andaliman extract (ethanol and aquadest) contains active compounds in the form of flavonoids, tannins, saponins, and steroids.
The Effect of Torbangun (Coleus amboinicus Lour) Leaf Extract on Antibiotic Resistant Bacteria Escherichia coli pBR322 and Toxicity Tests on Artemia salina Leach Trini Suryowati; John Jackson Yang; Lusia Sri Sunarti; Maria Bintang
Indonesian Journal of Applied Research (IJAR) Vol. 5 No. 1 (2024): Indonesian Journal of Applied Research (IJAR)
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/ijar.v5i1.388

Abstract

Inappropriate antibiotic use can lead to antibiotic resistance, causing many problems in the treatment of Escherichia coli infection. One way to avoid resistance is to use the traditional medicine Coleus amboinicus Lour, also known as Torbangun in Indonesia. The purpose of this study was to determine the inhibitory ability of 70% ethanol extract of Torbngun leaf against Escherichia coli pBR322 has plasmid pBR322, which is resistant to antibiotics Ampicillin and Tetracycline based on activity and minimum inhibitory concentration. Extraction was carried out using the maceration method. The presence of inhibition zones indicated antibacterial activity. The appearance of the inhibition zone at the minimum concentration indicated the minimum inhibitory concentration. Following this, the cytotoxic activity was evaluated using the brine shrimp lethality test. Data analysis was performed using an unpaired t-test using GraphPad Prism® software. Antibacterial activity tests showed that a 15% torbangun leaf extract concentration had inhibitory power against Escherichia coli pBR322. The toxicity test of torbangun leaf extract against Artemia salina Leach shrimp larvae showed LD50 results at a concentration of 150 ppm.
Co-Authors Fri Rahmawati Irene Rumiris Bavelina Lusia Sri Sunarti Maria Bintang Trini Suryowati