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All Journal Media Penelitian dan Pengembangan Kesehatan Jurnal Health Sains
Saptuti Chunaeni, Saptuti
Rumah Sakit Kanker Dharmais, Jakarta
Decision Sciences, Operations Research & Management Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Efektivitas Iradiasi terhadap Penurunan Limfosit T pada Komponen Sel Darah Merah Pekat Kadir, Sheila; Setiawaty, Vivi; Kosasih, Agus; Chunaeni, Saptuti
Media Penelitian dan Pengembangan Kesehatan Vol 26, No 1 Mar (2016)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (332.294 KB)

Abstract

AbstrakPemberian transfusi darah merupakan salah satu tindakan medis untuk penyelamatan nyawa (life saving)dan penyembuhan penyakit, tetapi di sisi lain tindakan ini juga memiliki risiko atau komplikasi. Salahsatu komplikasi yang dikenal adalah Transfusion-Associated Graft-vs-Host Disease (TAGVHD) yangmenyebabkan berproliferasinya limfosit T yang kemudian akan diikuti oleh proses engraft (tertanam)di dalam tubuh resipien khususnya yang berada dalam kondisi imunokompeten seperti pasien kankeratau dengan penyakit autoimun. Saat ini, satu–satunya metode yang dapat diterima untuk mencegahkomplikasi tersebut adalah dengan melakukan iradiasi darah. Penelitian ini bertujuan untuk mengetahuidosis iradiasi dan waktu penyinaran yang tepat untuk menurunkan jumlah CD 3+ dan CD 4+ sebagaipenyebab terjadinya TAGVHD. Hasil penelitian dapat dijadikan rekomendasi untuk prosedur iradiasiterhadap komponen sel darah merah pekat yang akan diberikan pada pasien-pasien imunokompetendi RS Kanker Dharmais Jakarta. Penelitian ini menggunakan disain penelitian eksperimental denganpemeriksaan time series yang dilakukan terhadap 54 kantong komponen sel darah merah pekat denganumur simpan tidak lebih dari satu hari. Pengujian dilakukan terhadap jumlah CD 3+ dan CD 4+ dalamtiga dosis dengan tiga serial waktu berbeda. Terjadi penurunan secara bermakna jumlah CD 3+ denganpenyinaran dosis 3000 cGy dan CD 4+ dengan penyinaran dosis 2500 dan 3000 cGy pada komponen seldarah merah pekat yang dilakukan iradiasi pada waktu penyinaran 3 jam dan 5 jam. Dosis penyinaran2500 cGy dan setelah 5 jam penyinaran memberikan penurunan viabilitas CD 3+.Kata Kunci: iradiasi, Transfusion-Associated Graft-vs-Host Disease (TAGVHD), CD 3+, CD 4+ AbstractBlood transfusion is a medical treatment for life-saving and cure the disease. On the other hand thesetreatment also have risks or complications, one of which is known as Transfusion-Associated Graftvs-Host Disease (TAGVHD) that may cause proliferation T lymphocytes and follow by a processengraft (embedded) in the recipient’s body at a state of immunocompetent. This condition is commonlyexperienced by patients with impaired immunological systems such as cancer patients or autoimmunediseases. Currently, one - the only acceptable method to prevent such complications by way of bloodirradiation. The aim of the study is to determine the irradiation dose and exposure time in reducingthe amount of CD 3+ and CD 4+ which is the cause of the TAGVHD. The results of this study will be arecommendation for action to the irradiation of packed red cell that will be given in immunocompetentpatients in Jakarta Dharmais Cancer Hospital. This study used an experimental research design timeseries with the examination conducted on 54 bags of packed red cell with the storage time was nolonger than one day. The experiments were conducted on the number of CD 3+ and CD 4+ in three doseswith three different time series. We found the significant decline in the number of CD 3+with 3000 cGyirradiation dose and CD 4+ with 2500 dan 3000 cGy irradiation doses in packed red cell irradiation at 3 to5 hours of irradiation time. The 2500 cGy irradiation doses for 5 hours decreased the viability of CD 3+.Keywords: irradiation, Transfusion-Associated Graft-vs-Host Disease (TAGVHD), CD 3+, CD 4+
The Effect of Platelet Aditive Solution In Maintaining the Quality and Function of Concentrated Platelets In The Pooling Method of Buffy Coat Leukofiltered Wido Sari Nawangsih, Idah; Widia A. Jusman, Sri; Chunaeni, Saptuti
Jurnal Health Sains Vol. 6 No. 1 (2025): Jurnal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v6i1.1537

Abstract

The availability of platelets in the Indonesian Red Cross (PMI) Blood Transfusion Unit (UDD) has been significantly high, with 767,680 bags collected in 2019, increasing to 957,397 bags in 2021. The dengue fever outbreak alongside the COVID-19 pandemic led to a nearly twofold increase in the demand for concentrated platelets (TP) in hospitals from 2021. However, platelet additive solution (PAS), which can extend platelet shelf life, is not yet utilized in Indonesia. This study aims to investigate whether TP obtained using the buffy coat leukofiltered pooling method and stored with PAS can improve platelet quality during storage. A series of laboratory tests were conducted to evaluate platelet count, pH levels, and aggregation function using ADP inspection, monitored over a storage period from day zero to day seven. The results indicate that the addition of PAS effectively maintains platelet quality, pH stability, and platelet function throughout the storage duration. This is attributed to the nutrient-rich composition of PAS, which contains glucose, sodium acetate, sodium chloride, phosphate, magnesium, and potassium, ensuring the preservation of platelet integrity. The findings highlight the potential benefits of PAS implementation in Indonesia to enhance platelet storage efficiency and availability, particularly during periods of high demand. Future research should explore the optimal PAS formulation for different storage conditions, cost-effectiveness, and clinical efficacy in transfusion settings to support broader adoption of this technology in blood banking.
Co-Authors Agus Kosasih, Agus Jusman, Sri Widia Azraki Sheila Kadir, Sheila Vivi Setiawaty Wido Sari Nawangsih, Idah