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All Journal Media Penelitian dan Pengembangan Kesehatan Jurnal Biotek Medisiana Indonesia INJURITY: Journal of Interdisciplinary Studies
Agus Kosasih, Agus
Rumah Sakit Kanker Dharmais, Jakarta
Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Health Professions Public Health Social Sciences

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Efek Berbagai Dosis Radiasi Terhadap Fragilitas Eritrosit dan Kadar Kalium pada Produk Sel Darah Merah Pekat Sidabutar, David H; Setiawaty, Vivi; Soedarmono, Yuyun SM; Kosasih, Agus
Jurnal Biotek Medisiana Indonesia Vol 4, No 1 (2015)
Publisher : Central Basic Biomedical and Health Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.703 KB)

Abstract

One of the delayed transfusion reactions that are fatal is TA GVHD (Transfusion Associated Graft Versus Host Disease). TA incidence of GVHD in immunocompromised patients is estimated at 0.1 to 1.0% with a mortality rate of approximately 80-90% .7 Efforts irradiation of cellular blood components is currently the most efficient way and a reliable way to prevent TA-GVHD. This study aims to determine the effect of various doses of irradiation effects on red blood cells during storage.This study used a descriptive analytic design at 54 red blood cell preparations that meet the inclusion and exclusion criteria. The preparation of red blood cells were divided into 4 groups, ie the group that received 2500,3000,5000 cGy dose and control. OFT testing and potassium levels on the first day, the third and fifth storage. An increase in potassium levels was statistically significant from the first day after irradiation at all doses. There were no significant differences in red blood cell membrane resistance to all doses of irradiation during storage until the fifth day. Irradiation at doses of 2500-5000 cGy can cause increased pottasium level and does not cause changes fragility of red blood cells stored for 5 days after irradiation. The need for further research on the quality of the preparation of red blood cells during storage after irradiation as seen levels of hemolysis (hemolysis rate).Keyword : Blood transfusion, Irradiated, OFT and potassium AbstrakSalah satu reaksi transfusi lambat yang bersifat fatal adalah TA GVHD (Transfusion Associated Graft Versus Host Disease). Kejadian TA GVHD pada pasien immunocompromised diperkirakan sebesar 0,1- 1,0% dengan angka kematian sekitar 80- 90%.7 Upaya radiasi komponen darah seluler saat ini merupakan cara yang paling efisien dan dapat diandalkan untuk mencegah TA-GVHD. Penelitian ini bertujuan untuk mengetahui pengaruh efek berbagai dosis radiasi terhadap sel darah merah selama penyimpanan. Penelitian ini menggunakan desain deskriptif analitik pada 54 sediaan sel darah merah yang memenuhi kriteria inklusi dan eksklusi. Sediaan sel darah merah dibagi menjadi 4 grup, yaitu grup yang mendapat dosis 2500,3000,5000 cGy dan kontrol. Dilakukan pengujian OFT dan kadar kalium pada hari pertama, ketiga dan kelima penyimpanan. Terjadi peningkatan kadar kalium yang bermakna secara statistik mulai dari hari pertama setelah dilakukan radiasi pada semua dosis. Tidak ditemukan perbedaan bermakna ketahanan membran sel darah merah terhadap semua dosis radiasi selama penyimpanan sampai hari kelima. Radiasi pada dosis 2500-5000 cGy dapat menyebabkan peningkatan kadar kalium dan tidak menyebabkan perubahan fragilitas sel darah merah yang disimpan selama 5 hari setelah radiasi. Perlunya penelitian lebih lanjut mengenai mutu sediaan sel darah merah selama penyimpanan setelah dilakukan radiasi seperti melihat tingkat hemolisis (hemolisis rate).Kata kunci: Transfusi darah, Radiasi, OFT, Kalium
Efektivitas Iradiasi terhadap Penurunan Limfosit T pada Komponen Sel Darah Merah Pekat Kadir, Sheila; Setiawaty, Vivi; Kosasih, Agus; Chunaeni, Saptuti
Media Penelitian dan Pengembangan Kesehatan Vol 26, No 1 Mar (2016)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

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Abstract

AbstrakPemberian transfusi darah merupakan salah satu tindakan medis untuk penyelamatan nyawa (life saving)dan penyembuhan penyakit, tetapi di sisi lain tindakan ini juga memiliki risiko atau komplikasi. Salahsatu komplikasi yang dikenal adalah Transfusion-Associated Graft-vs-Host Disease (TAGVHD) yangmenyebabkan berproliferasinya limfosit T yang kemudian akan diikuti oleh proses engraft (tertanam)di dalam tubuh resipien khususnya yang berada dalam kondisi imunokompeten seperti pasien kankeratau dengan penyakit autoimun. Saat ini, satu–satunya metode yang dapat diterima untuk mencegahkomplikasi tersebut adalah dengan melakukan iradiasi darah. Penelitian ini bertujuan untuk mengetahuidosis iradiasi dan waktu penyinaran yang tepat untuk menurunkan jumlah CD 3+ dan CD 4+ sebagaipenyebab terjadinya TAGVHD. Hasil penelitian dapat dijadikan rekomendasi untuk prosedur iradiasiterhadap komponen sel darah merah pekat yang akan diberikan pada pasien-pasien imunokompetendi RS Kanker Dharmais Jakarta. Penelitian ini menggunakan disain penelitian eksperimental denganpemeriksaan time series yang dilakukan terhadap 54 kantong komponen sel darah merah pekat denganumur simpan tidak lebih dari satu hari. Pengujian dilakukan terhadap jumlah CD 3+ dan CD 4+ dalamtiga dosis dengan tiga serial waktu berbeda. Terjadi penurunan secara bermakna jumlah CD 3+ denganpenyinaran dosis 3000 cGy dan CD 4+ dengan penyinaran dosis 2500 dan 3000 cGy pada komponen seldarah merah pekat yang dilakukan iradiasi pada waktu penyinaran 3 jam dan 5 jam. Dosis penyinaran2500 cGy dan setelah 5 jam penyinaran memberikan penurunan viabilitas CD 3+.Kata Kunci: iradiasi, Transfusion-Associated Graft-vs-Host Disease (TAGVHD), CD 3+, CD 4+ AbstractBlood transfusion is a medical treatment for life-saving and cure the disease. On the other hand thesetreatment also have risks or complications, one of which is known as Transfusion-Associated Graftvs-Host Disease (TAGVHD) that may cause proliferation T lymphocytes and follow by a processengraft (embedded) in the recipient’s body at a state of immunocompetent. This condition is commonlyexperienced by patients with impaired immunological systems such as cancer patients or autoimmunediseases. Currently, one - the only acceptable method to prevent such complications by way of bloodirradiation. The aim of the study is to determine the irradiation dose and exposure time in reducingthe amount of CD 3+ and CD 4+ which is the cause of the TAGVHD. The results of this study will be arecommendation for action to the irradiation of packed red cell that will be given in immunocompetentpatients in Jakarta Dharmais Cancer Hospital. This study used an experimental research design timeseries with the examination conducted on 54 bags of packed red cell with the storage time was nolonger than one day. The experiments were conducted on the number of CD 3+ and CD 4+ in three doseswith three different time series. We found the significant decline in the number of CD 3+with 3000 cGyirradiation dose and CD 4+ with 2500 dan 3000 cGy irradiation doses in packed red cell irradiation at 3 to5 hours of irradiation time. The 2500 cGy irradiation doses for 5 hours decreased the viability of CD 3+.Keywords: irradiation, Transfusion-Associated Graft-vs-Host Disease (TAGVHD), CD 3+, CD 4+
Road Damage Analysis On Inter-City Roads Using Pavement Condition Index (PCI) Approach In West Java Indonesia Hariani, Mira Lestira; Taufik, Ahmad; Suparman, Suparman; Kosasih, Agus; Farhan, Ohan
Interdiciplinary Journal and Hummanity (INJURITY) Vol. 4 No. 7 (2025): INJURITY: Journal of Interdisciplinary Studies
Publisher : Pusat Publikasi Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58631/injurity.v4i7.1464

Abstract

Poor road infrastructure conditions have a significant impact on transportation efficiency, user safety, and logistics costs, especially in areas with tropical climates and heavy vehicle traffic such as in West Java. This study aims to evaluate the condition of road pavement on the Jangga–Cikamurang Road section in Indramayu Regency using the Pavement Condition Index (PCI) method. The survey was conducted visually along 1 kilometer of road, which was divided into 10 segments of 100 meters each. Observations included identification of the type of damage, severity, and extent of damage in each segment. The results of the study showed that the most dominant types of damage were alligator cracking (42.47%) and depression (33.63%) with high severity. The PCI values obtained varied between 6 and 78, with 60% of segments categorized as poor to failed, and only 10% in satisfactory condition. These findings indicate that most road sections are in unserviceable conditions and require structural handling. Based on the PCI value classification, reconstruction actions are recommended for segments with PCI < 55, overlay and structural maintenance for PCI 55–70, and preventive maintenance for PCI > 70. This study confirms the importance of implementing PCI as a technical decision-making tool in sustainable road maintenance planning.
Co-Authors Abdulmuthalib Abdulmuthalib Ahmad Taufik Ardian Saputra, Ardian Aru W Sudoyo Ary H Reksodiputro, Ary H Auda Aziz, Auda Cosphiadi Irawan David H Sidabutar, David H Djumhana Atmakusumah, Djumhana Idrus Alwi Linda Lison, Linda Lyana Lyana, Lyana Merry Wintery, Merry Mira Lestira Hariani Ohan Farhan Saptuti Chunaeni, Saptuti Sheila Kadir, Sheila Sri Inggriani, Sri Suparman Suparman Teguh Santoso Vivi Setiawaty Yuyun SM Soedarmono, Yuyun SM