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All Journal Narra J Trends in Infection and Global Health Indonesian Journal of Pharmacology and Therapy
Fauzul Husna
Department of Pharmacology, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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SARS-CoV-2 infection and male fertility problems Ika Inda Bani; Zulkarnain Zulkarnain; Gholib Gholib; Dedy Syahrizal; Fauzul Husna; Winda Yulia; Mulkan Azhari
Trends in Infection and Global Health Vol 2, No 2 (2022): December 2022
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v2i2.29426

Abstract

In 2019, the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), has killed more than 6.6 millions of people around the world as of end of 2022. The long-term impact of COVID-19 is persisted, including its impact on male reproduction. SARS-CoV-2 enters into host cells using the angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) receptors. Both of these receptors are expressed more in men, and therefore men are more susceptible to SARS-CoV-2. COVID-19 potentially cause infertility by damaging testicular tissues and interfering with the process of spermatogenesis. A decrease in serum levels of testosterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) as well as a decrease in sperm quality in men with COVID-19 compared to healthy men of the same age has been reported in several studies. Utilizing existing research data, this study aims to explore in detail of how SARS-CoV-2 tends to affect male fertility.
Inhibitory effect of yellow cempaka leaf (Michelia champaca Linn.) against Staphylococcus aureus and Escherichia coli Fauzul Husna; Teuku Heriansyah; Shabrina Masturah
Indonesian Journal of Pharmacology and Therapy Vol 7 No 2 (2026)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.28181

Abstract

Several studies have been conducted to develop herbal plants as alternatives to address infections. Yellow cempaka (Michelia champaca Linn.) is a natural ingredient that can serve as an alternative treatment. This study used a posttest-only control group to examine the antibacterial activity of the disc diffusion method against Staphylococcus aureus and Escherichia coli. This study included four treatment groups (10, 20, 40, and 80% ethanol extracts) and two control groups (10 μg amoxicillin for S. aureus, 5 μg ciprofloxacin for E. coli, and 96% ethanol as a negative control). The results showed that the ethanol extract of M. champaca leaves exhibited antibacterial activity against S. aureus at all concentrations tested, with mean inhibition zone diameters ranging from 13.70 mm to 23.11 mm. Statistical analysis showed that the 20% extract concentration had antibacterialactivity comparable to the positive control (p > 0.05), whereas the 40% and 80% concentrations showed significantly different inhibition zone diameters from the positive control (p < 0.05). In contrast, the ethanol extract of M. champaca leaves showed weak antibacterial activity against E. coli at all concentrations tested, with mean inhibition zone diameters ranging from 6.38 mm to 7.63 mm, which were significantly different from the positive control (p<0.05). These findings revealed that the ethanol extract of M. champaca leaves has potential as an alternative treatment for S. aureus infections. However, further research is needed to isolateand identify specific active compounds and to evaluate their efficacy and safety.
Association of posterior calcaneal enthesophytes with ultrasonographic Achilles tendon abnormalities: A comparative radiographic and ultrasonographic study Suci Ananda; Masna D. Abdullah; Fauzul Husna; Iskandar Zakaria; Nita Elvira
Narra J Vol. 6 No. 3 (2026): December 2026 (In Press)
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i3.3134

Abstract

Achilles tendinopathy may be accompanied by tendon thickening and fibrillar pattern abnormalities on ultrasonography. Posterior calcaneal enthesophytes are frequently identified on lateral ankle radiographs, but their relationship with Achilles tendon abnormalities remains unclear. The aim of this study was to assess the associations of posterior calcaneal enthesophyte presence and length with ultrasonographic findings of the Achilles tendon. A hospital-based cross-sectional study included 46 patients with heel or posterior ankle pain, with 54 ankles used as the unit of analysis. Enthesophyte presence and length were assessed using lateral ankle radiography, whereas Achilles tendon thickness and fibrillar pattern abnormalities were evaluated using ultrasonography. Associations were analyzed using Fisher’s exact test, and continuous measurements were compared using the Mann–Whitney U test. Posterior calcaneal enthesophytes were identified in 40.7% of ankles. Tendon thickening and fibrillar pattern abnormalities were observed in 1.9% and 9.3% of ankles, respectively. Enthesophyte presence was not significantly associated with tendon thickening (p=0.407), and tendon thickness did not differ significantly between ankles with and without enthesophytes (p=0.063). Fibrillar pattern abnormalities were observed in 22.7% of ankles with enthesophytes and in none of the ankles without enthesophytes (p=0.008). An enthesophyte length ≥0.85 mm was associated with fibrillar pattern abnormalities (p=0.005) but not tendon thickening (p=0.370). Median enthesophyte length was greater in ankles with fibrillar abnormalities than in those without abnormalities (2.50 mm vs 0.00 mm; p=0.005). This study highlights that posterior calcaneal enthesophytes were associated with fibrillar pattern abnormalities but not tendon thickening. Since ultrasonographic abnormalities were uncommon and clinical outcomes were not assessed, these preliminary cross-sectional associations require confirmation in larger prospective studies.
Co-Authors Dedy Syahrizal Gholib Gholib Ika Inda Bani Iskandar Zakaria Masna D. Abdullah Mulkan Azhari Nita Elvira Shabrina Masturah Suci Ananda Teuku Heriansyah Winda Yulia Zulkarnain Zulkarnain