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All Journal Nusantara Medical Science Journal Mandala of Health : A Scientific Journal
Salman Ardi Syamsu
Unknown Affiliation
Dentistry Health Professions Materials Science & Nanotechnology Neuroscience Public Health

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Original Article HUBUNGAN EKSPRESI CYCLOOXYGENASE-2 (COX-2) DENGAN DISEASE FREE SURVIVAL DAN OVERALL SURVIVAL PADA PENDERITA KANKER PAYUDARA Prihantono Prihantono; Juhamran Juhamran; Zaenal Abidin; Haryasena Haryasena; Salman Ardi Syamsu
Mandala Of Health Vol 12 No 1 (2019): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (443.883 KB) | DOI: 10.20884/1.mandala.2019.12.1.1045

Abstract

Cyclooxygenase-2 (COX-2) berperan dalam pertumbuhan tumor dan metastasisnya yang berdampak pada buruknya prognosis. Tujuan penelitian ini untuk mengetahui hubungan ekspresi COX-2 terhadap disease free survival dan overall survival pada pasien kanker payudara. Penelitian ini bersifat observasional menggunakan desain kohort dengan periode follow up selama 24 bulan. Hasil: Ekspresi COX-2 ditemukan pada 21 sampel (42%) dari 50 pasien kanker payudara. Selama follow up 24 bulan, lama DFS pada COX-2 negatif (20,1 bulan) lebih lama dibandingkan pada COX-2 positif (14,0 bulan) dan menunjukkan hubungan yang signifikan (p<0,01). Lama OS pada COX-2 negatif (22,6 bulan) lebih lama dibandingkan pada COX-2 positif (17,8 bulan) yang juga menunjukkan hubungan yang signifikan (p<0,01). Terdapat hubungan yang signifikan antara ekspresi COX-2 dengan disease free survival dan overall survival pada pasien kanker payudara. COX-2 bisa dijadikan salah satu faktor prognostik kanker payudara.
Mandibular Metastasis as a Rare Presentation of Follicular Variant Papillary Thyroid Carcinoma: A Case Series Hamdani, William; Patabang, Erwin A.; Haryasena , Haryasena; Ferianto, Djonny; Pieter Jr., John; Salman Ardi Syamsu
Nusantara Medical Science Journal Vol. 10 No. 2 (2025): Volume 10 Issue 2, July - December 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i2.48914

Abstract

Introduction: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. The follicular variant of papillary thyroid carcinoma (FV-PTC) represents a distinct histologic subtype that tends to spread hematogenously to distant organs, including bone. Mandibular metastasis from FV-PTC is exceedingly rare and may pose a diagnostic challenge, particularly when it precedes recognition of the primary thyroid lesion. Presentation of case:   We report two Asian female patients presenting with mandibular masses. The first patient had a history of total thyroidectomy for papillary thyroid carcinoma (follicular variant) ten years earlier. Imaging revealed an extensive osteolytic lesion of the right mandible. Histopathology of an incisional biopsy confirmed metastatic PTC, and the patient underwent right hemimandibulectomy with immediate reconstruction using a titanium plate. The second patient presented with a large, painful left mandibular mass without any history or clinical evidence of thyroid disease. Imaging showed a destructive lytic lesion of the left mandible, while neck ultrasonography revealed no thyroid enlargement. Biopsy suggested FV-PTC of thyroid origin. The patient underwent left hemimandibulectomy with titanium plate reconstruction. Final histopathology in both cases confirmed FV-PTC metastasis to the mandible. Conclusion: Mandibular metastasis from FV-PTC is a rare manifestation that may occur as late recurrence after thyroidectomy or as the first indication of an occult thyroid carcinoma. Comprehensive diagnostic workup and appropriate surgical reconstruction are crucial to achieve local disease control and preserve function. Clinicians should consider metastatic thyroid carcinoma in the differential diagnosis of lytic mandibular lesions, even in the absence of a palpable thyroid
Co-Authors Ferianto, Djonny Hamdani, William Haryasena , Haryasena Haryasena Haryasena Juhamran Juhamran Patabang, Erwin A. Pieter Jr., John Prihantono Prihantono Zaenal Abidin