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All Journal JURNAL JAMU KUSUMA Jurnal Kesehatan Farmasi Jurnal Kesehatan dr. Soebandi
Septiana Laksmi Ramayani
Poltekkes Kemenkes Surakarta
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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POTENSI GEL HANDSANITIZER EKSTRAK DAUN KITOLOD (Isotoma longiflora L.) SEBAGAI ANTIBAKTERI TERHADAP BAKTERI Staphylococcus aureus Septiana Laksmi Ramayani
Jurnal Jamu Kusuma Vol. 2 No. 1 (2022): JURNAL JAMU KUSUMA
Publisher : Poltekkes Kemenkes Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (269.398 KB) | DOI: 10.37341/jurnaljamukusuma.v2i1.26

Abstract

Staphylococcus aureus is a Gram positive and commensal bacteria that colonizes 30% of healthy individuals in various parts of the body. Kitolod (Isotoma longiflora L )leaf extract has antibacterial activity against Staphylococcus aureus bacteria and may be developed into hand sanitizer gel preparations. The purpose of this study was to determine the antibacterial activity of the hand sanitizer gel preparation of kitolod leaf extract. Kitolod leaf extract was macerated with 96% ethanol and then formulated into a hand sanitizer gel preparation. Antibacterial activity was carried out using the Kirby Bauer method using a negative control of 10% DMSO and a gel base, while the positive control was a gel hand sanitizer on the market. The results showed that the negative control did not show antibacterial activity, while the positive control, kitolod leaf extract and hand sanitizer gel preparations of kitolod leaf extract gave a clear zone indicating the presence of antibacterial activity against Staphylococcus aureus bacteria. The antibacterial activity of the kitolod leaf extract hand sanitizer gel was classified in the strong category
Pengaruh Ukuran Partikel dan Lama Penyulingan Terhadap Jumlah Rendemen Minyak Atsiri Serbuk Temulawak (Curcuma xanthorrhiza) Septiana Laksmi Ramayani; Chatarina Hartiningty Ratna Meilyanawati
Jurnal Kesehatan Farmasi Vol 4, No 2 (2022)
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (659.245 KB) | DOI: 10.36086/jpharm.v4i2.1450

Abstract

Background: Java tumeric (Curcuma xanthorrhiza) is a medicinal plant native to Indonesia which has been empirically proven to be efficacious for health to cure various types of diseases. One of the compounds in Java tumeric is essential oil. The purpose of this study was to determine the effect of particle size and distillation time on the yield of Java tumeric essential oil. Method: The extraction method used is hydrodistillation. The variables in this study were particle size (425µm and 250µm) and distillation time (3.4 and 5 hours). The data obtained were analyzed using Kruskal Wallis and followed by Mann Whitney. Results: The results showed that a particle size of 250µm resulted in a greater yield of essential oils than a particle size of 425µm. Distillation time of 5 hours produces a greater yield of essential oils than distillation time of 4 hours or 3 hours. The smaller the particle size and the longer the distillation time, the greater the yield of essential oil produced. Conclusion: Particle size and distillation time affect the yield of java tumeric essential oil.
The Effect of Kitolod (Isotoma Longiflora) Leaf Extract Concentration in Gel Formula on Total Phenolic and Flavonoid Levels Septiana Laksmi Ramayani; Dania Fauzita Rarasati; Yuliya Rizky Widyastuti
Jurnal Kesehatan dr. Soebandi Vol 12 No 1 (2024): Jurnal Kesehatan dr. Soebandi
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jkds.v12i1.573

Abstract

Belonging to the Campanulaceae family, Kitolod (Isotoma longiflora) possesses antioxidant properties crucial for wound healing; presenting a case for its formulation into a gel and investigating the total phenolic and flavonoid content of kitolod leaf extract when in gel form is essential to understand its capabilities as an anti-inflammatory and wound-healing gel, as well as to examine the possible correlation between the extract's concentration and its phenolic and flavonoid content. This study assessed how different concentrations of kitolod leaf extract affect the total phenolic and flavonoid levels in a gel formulation. Using 96% ethanol, kitolod leaves were macerated. The gel formulations contained varying concentrations of kitolod leaf extract: F1(5%), F2(10%), and F3(20%). The presence of phenols and flavonoids was confirmed through qualitative tests using FeCl3 1% for phenols and the Shinoda test for flavonoids. The findings confirmed that the total levels of phenolics and flavonoids increased with the concentration of kitolod leaf extract in the gel. SPSS analysis showed a strong correlation between extract concentration in the gel and the amounts of total phenolics and flavonoids, highlighting a positive relationship between these two chemical compounds since they are in the same category.
Co-Authors Chatarina Hartiningty Ratna Meilyanawati Dania Fauzita Rarasati Yuliya Rizky Widyastuti