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All Journal Indonesian Journal of Global Health research Gaster Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan
Yuriz Bakhtiar
Universitas Diponegoro
Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Sensitivitas dan Spesifitas Skor Stroke Literature Review Sutarwi Sutarwi; Yuriz Bakhtiar; Nana Rochana
Gaster Vol 18 No 2 (2020): AGUSTUS
Publisher : P3M Universitas 'Aisyiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (690.318 KB) | DOI: 10.30787/gaster.v18i2.521

Abstract

Latar belakang; Pemeriksaan penunjang untuk menentukan type stroke secara akurat adalah pemeriksaan CT-Scan dan Magnetic Resonance Imaging (MRI), akan tetapi alat penunjang ini relatif mahal dan tidak dapat diakses untuk sebagian besar rumah sakit yang masih kekurangan sumber daya.Tujuan penelitian;untuk membandingkan tingkat akurasi, sensitivitas serta spesifisitas antara Siriraj skor stroke, Allen skor stroke, Algoritma stroke Gadjah Mada Serta Dave&Djoenaidi dalam membedakan stroke haemoragik dan stroke iskemik pada fase akut. Metode:;jenis penelitian adalah dssriptif dengan pencarian literature menggunakan database online untuk studi yang ditulis dalam bahasa Inggris dan artikel diidentifikasi dengan menggunakan kriteria yang telah ditetapkan dengan melihat membandingkan nilai sensitivitas dan spesifisitas skor stroke yang digunakan.Hasil; sensitivitas dan spesifisitas untuk Skor Stroke Siriraj yaitu 0,69 (95% CI 0,62-0,75) dan 0,83 (95% CI 0,75-0,88) untuk stroke iskemik dan 0,65 (95% CI 0,56-0,73) dan 0,88 ( 95% CI 0,83-0,91) untuk stroke hemoragik. Sensitivitas dan spesifisitas skor stroke Guy adalah 0.70 (95% CI 0,53-0,83) dan 0,79 (95% CI 0,68-0,87) untuk stroke iskemik dan 0,54 (95% CI 0,42-0,66) dan 0,89 (95% CI 0,83 -0,94) untuk stroke hemoragik, Untuk Sistem Skor Stroke Dave&Djoenaidi memiliki Sensitivitas 90,3%, Spesifitas 89,1%, Akurasi 89,75, dan AUC  97,3%. Kesimpulan; sistem skor oleh Dave dan Djoenadi lebih akurat karena memiliki keandalan yang tinggi. Perlu dilakukan analisis lebih lanjut untuk mengidentifikasi skor Dave & Djoenaidi untuk mendeteksi dini terjadinya stroke Infark maupun stroke Hemoragik. 
The Effect of Mindfulness on Pain and IL-6 Level Serum ln Cancer Patient Anisa Ell Raharyani; Yuriz Bakhtiar; Awal Prasetyo
Indonesian Journal of Global Health Research Vol 5 No 1 (2023): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (135 KB) | DOI: 10.37287/ijghr.v5i1.1483

Abstract

Pain is a common symptom experienced by patients of nasopharyngeal cancer. This pain is caused by metastasis, infection and medication. Pain can result in physical, psychological (stress), social, and spiritual impact as well as it causes the emergence of perception about death that can decrease the life quality. Pain response affects changes on psychoneuroimmunology. Integrated treatment on pain is needed. Mindfulness is one form of integrative therapy to relieve pain intensity and reduce pro-inflammatory cytokine activity as a pain response. Objective to show effect Mindfullnes on pain and Il-6 serum level in cancer patient especially nasopharyngeal cancer. Experimental clinical trial one group pre and post test design without control. Sample collected based on consecutive sampling. Pain intensity is measured by using VAS, the neutrophils count is measured by using analyzer packet and IL-6 level is measured with ELISA. The instrument validity test showed r=0.90, while the reability test showed more than 0.90. Data were analyzed using t-test. Average difference of pain intensity before therapy, (mean4,07 + 0,99), there is a difference in the pain level, neuthropyl and IL-6. Mindfulness is proved to give effect on pain intensity, neutrophils count and IL-6 level on patients with nasopharyngeal cancer.
The Effects of Diabetes Mellitus on Bone Healing : A Systematic Review of RANKL and OPG Maya Indah Triwardani; Endang Mahati; Yuriz Bakhtiar
Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan Vol. 4 No. 3 (2026): September: Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebida
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/corona.v4i3.2403

Abstract

Background: Diabetes mellitus (DM) impairs fracture healing by promoting advanced glycation end products, oxidative stress, and an imbalance in the RANKL/osteoprotegerin (OPG) system, thereby increasing bone resorption and inhibiting osteoblast activity. Objective: To evaluate the effects of DM on fracture healing as reflected by RANKL and OPG levels. Methods: This systematic review followed PRISMA and Synthesis without Meta-analysis (SWiM) guidance. PubMed, Scopus, and Google Scholar were searched for English-language studies published from January 2021 through May 2026. Eligible in vivo studies compared diabetic and non-diabetic rat fracture models and reported RANKL and/or OPG outcomes. Study selection, data extraction, and risk-of-bias assessment were conducted independently using the SYRCLE tool for animal studies. Results: Three studies met the inclusion criteria. Diabetic groups consistently showed higher RANKL and lower OPG than non-diabetic controls, indicating a higher RANKL/OPG ratio and a shift toward osteoclast-mediated bone resorption. These changes were accompanied by impaired bone formation and delayed healing-related outcomes. Conclusion: DM is associated with a consistent pro-resorptive imbalance in the RANKL/OPG system during fracture healing. The concordance across animal studies supports this pathway as a potential therapeutic target, while standardized studies and clinical validation remain necessary.
Co-Authors Awal Prasetyo Endang Mahati Maya Indah Triwardani Nana Rochana Raharyani, Anisa Ell Sutarwi Sutarwi