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All Journal Jurnal Sehat Mandiri Eduvest - Journal of Universal Studies
Endang Mahati
Universitas Diponegoro
Aerospace Engineering Computer Science & IT Environmental Science Health Professions Neuroscience Public Health Social Sciences

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Stabilitas Vitamin D3 pada Dadih (Susu Kerbau Fermentasi) Sari Bema Ramdika; Diana Nur Afifah; Anang Mohamad Legowo; Muflihatul Muniroh; Yora Nindita; Endang Mahati
Jurnal Sehat Mandiri Vol 18 No 1 (2023): Jurnal Sehat Mandiri, Volume 18, No.1 Juni 2023
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v18i1.914

Abstract

Vitamin D deficiency and inadequacy is a worldwide problem that can cause serious health problems. Vitamin D reduce the risk of osteoporosis, cancer, diabetes mellitus, and cardiovascular disease. Vitamin D is obtained from four sources such as sun exposure, food, supplements and fortification food. The research was conducted in October 2019. The purpose of this study was to see the stability of vitamin D3 in dadih during storage. The High Performance Liquid Chromatogaphy (HPLC) method was used to calculate vitamin D3 levels in fortified dadih. Quantification of vitamin D3 was done on day 0, day 3, day 9, day 16, day 23 and day 30. Statistical analysis showed that there was no significant difference in the level of vitamin D3 in dadih for 30 days of storage although there was a decrease in the level of vitamin D3 in dadih on the fourth week but it was not significantly (p> 0.05). In conclusion, Vitamin D3 in the dadih was stable for 30 days of storage although there was a decrease in vitamin D3 levels on the 16th and 30th days of storage due to the undetectable vitamin D3 in some samples. The addition of vitamin D3 to dadih is suggested using encapsulation techniques to increase solubility, longer shelf life, prevention of chemical degradation, better dispersibility, higher bioavailability and effectiveness.
Immunomodulatory Potential of Curcuma longa Extract as Adjuvant Therapy for Peritonitis: A Systematic Review of Inflammatory Biomarkers IL-6 and Myeloperoxidase Ishak Andreas Soritua Lumban Gaol; Endang Mahati; Erik Prabowo
Eduvest - Journal of Universal Studies Vol. 6 No. 4 (2026): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v6i4.53012

Abstract

Peritonitis is a severe inflammatory condition of the peritoneum associated with high morbidity and mortality, often progressing to sepsis due to excessive inflammatory responses. Pro-inflammatory cytokines such as interleukin-6 (IL-6) and neutrophil-derived enzymes like myeloperoxidase (MPO) play critical roles in disease progression and tissue damage. Current treatments primarily focus on infection control; however, adjunctive therapies targeting inflammation remain limited. This study aims to evaluate the potential of Curcuma longa extract as an adjuvant therapy in modulating IL-6 levels and MPO activity in peritonitis. This research employed a systematic review design following PRISMA 2020 guidelines. Literature was collected from Scopus, PubMed, Google Scholar, and ScienceDirect using predefined inclusion and exclusion criteria. A total of four eligible experimental studies (in vivo and in vitro) were analyzed. The findings demonstrate that Curcuma longa extract, particularly curcumin, significantly reduces IL-6 expression and modulates MPO activity, indicating decreased inflammatory response and neutrophil infiltration. These effects are associated with the inhibition of key inflammatory pathways such as NF-κB and MAPK.In conclusion, Curcuma longa shows promising potential as an adjunctive therapy for peritonitis by attenuating inflammatory biomarkers. However, further standardized studies and clinical trials are required to confirm its efficacy and optimal therapeutic dosage.
Co-Authors Anang M Legowo Diana Nur Afifah, Diana Nur Erik Prabowo Ishak Andreas Soritua Lumban Gaol Muflihatul Muniroh Sari Bema Ramdika Yora Nindita