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All Journal Medicinus : Jurnal Kedokteran
Jevon Lesmana
Department of Biology, Faculty of Science and Technology, Universitas Pelita Harapan, Tangerang, Banten
Medicine & Pharmacology Public Health

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Future Application of Oncolytic Viruses for Cancer Treatment Jevon Lesmana; Juandy Jo
Medicinus Vol 10, No 3 (2022): October 2022 - January 2023
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i3.6475

Abstract

Cancer treatments have developed over the years. A particular improvement is the utilization of oncolytic viruses to treat cancers. Oncolytic viruses are one of the immunotherapeutic tools that potentially could provide good results and benefits to the patients. Oncolytic viruses could mediate antitumor effects. Indeed, the connection between viral infections and cancer treatment have been reported historically. It is known that oncolytic viruses prefer to infect cancer cells rather than normal cells, resulting in the presentation of tumor-associated antigens to the immune system, boosting immunological activity in the tumor microenvironment, as well as assisting in the expression of inflammatory and immunomodulatory cytokines. Oncolytic viruses are a novel regimen in the cancer therapy, in which knowledge and technology of utilizing oncolytic viruses to treat cancer are still evolving. Importantly, clinical trials demonstrated that the viruses were well tolerated by cancer patients. Considering its potency and prospect, oncolytic viral treatments could be a useful additional tool for cancer therapy
Co-Authors Juandy Jo