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Isolation and Structure Determination of Stigmaterol from the Stem Bark of Lansium domesticum Corr. Cv. Kokossan Siska Elisahbet Sinaga; Fajar Fauzi Abdullah; Unang Supratman; Tri Mayanti; Rani Maharani
Chimica et Natura Acta Vol 10, No 3 (2022)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v10.n3.39240

Abstract

Indonesia is a tropical country with biodiversity and a source of natural compounds such as terpenoids, phenolic, flavonoids, and alkaloid groups. The steroid is one of the large groups of terpenoid compounds with various structures and bioactivities. The steroid was also commonly found in the Meliaceae family. One species of this family is Lansium domesticum Corr. which has been studied to have various activities from isolated compounds (limonoids, sesquiterpenoids, onoceranoids, cycloartanoids, and steroids) as well as from their extracts such as antidiarrheal, antimalarial, antimicrobial, antiinsecticide, antifeedant and were used as traditional medicine such as eye drops and scorpion stings. The n-hexane fraction from the bark of L. domesticum Cor. cv. Kokosan produced steroid compounds whose structure is determined by IR, 1H-NMR, 13C-NMR, and DEPT spectroscopy methods and compared with the literature. It was concluded that the steroid isolated was (22E)-stigmasta-5,22-dien-3ol and was first isolated from this genus. This compound was inactive against MCF-7 breast cancer cells with an IC50 value of 832.14 µM.
Pelatihan Pembuatan Lotion Antinyamuk Berbasis Minyak Atsiri untuk Meningkatkan Pengetahuan Siswa SMAN 30 Garut Aika Latifah Alawiyah; Fajar Fauzi Abdullah; Ruchiyat; Farid Perdana; Isye Martiani; Jasminum Sambact; Rahma Mekar Muharram
Agrokreatif: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 12 No. 2 (2026): Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/agrokreatif.12.2.367-375

Abstract

Mosquitoes are considered vectors responsible for dengue fever, malaria, and chikungunya. Applying anti-mosquito lotion is a precaution to avoid mosquito bites. Certain commercial items contain diethyltoluamide (DEET), which can be harmful to health and contaminate the environment when used for extended periods. Utilizing essential oils in a anti-mosquito lotion is more eco-friendly. This community service aimed to improve students’ understanding and ability to produce anti-mosquito lotion using essential oils. The training took place at SMAN 30 Garut, involving 35 students from classes X and XII. The training approach involves preparation; implementation (pre-test and post-test to evaluate participants’ knowledge levels, delivering material interactively, and practicing); and evaluating activities through satisfaction questionnaires. A paired t-test analysis of the pre-test and post-test results showed that a t-value of 3,25 with a p-value of 0,012 (< 0,05), indicating a significant improvement in the pupils’ knowledge of the subject matter and their skills in making mosquito-repellent lotion. The percentage of correct answers has increased from 68,57% (pre-test) to 86,35% (post-test). The results indicated that participants responded positively to the activities conducted. The results of the training showed an improvement in students’ understanding of the subjectand their ability to make anti-mosquito lotions. This activity not only provides insight into the use of natural products but also raises students’ interest in entrepreneurial oppoturnities and innovation within schools and the community.