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Nurul Hastuti Raun
STIKES Muhammadiyah Manado
Health Professions Public Health

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Uji Efektivitas Ekstrak Etanol Daun Jambu Mete (Anacardium occidentale L.) Sebagai Analgetik Pada Tikus Putih (Rattus norvegicus) Rahmat Ismail; Hamidah Sri Supriati; Nurul Hastuti Raun
Jurnal Sains dan Kesehatan Vol. 4 No. 2 (2020): Desember : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (134.269 KB) | DOI: 10.57214/jusika.v4i2.177

Abstract

Pain is a defense mechanism of the body and caused by tissue damage to the body due to injury, accident or medical action. Traditionally, cashew leaves were used in curing inflammation, pain, toothache, wound healing, rheumatism as well as dysentery. This study aims to determine the effectiveness of analgetic power of cashew leaf ethanol extract (Anacardium occidentale L.) in white rats (Rattus norvegicus). The research conducted is experimental research, with chemical excitatory methods. The test animals were divided into 5 groups with each treatment of 3 mice. Group I Na CMC 1%, group II Paracetamol, group III cashew leaf ethanol extract 10%, group IV cashew leaf ethanol extract 20%, and group V cashew leaf ethanol extract 40% given orally. Pain inductors are 1% induced acetic acid intraperitonially. Observed the amount of mice geliat for 1 hour and calculated percent analgetic power. The results obtained in this study have properties as analgetics with analgetic power concentration of 10%: 82.73%, concentration of 20%: 84.89%, and concentration of 40%: 88.48%.
Uji Efektivitas Ekstrak Etanol Daun Lire (Hemigraphis repanda (L) Hall F) Sebagai Antipiretik Pada Tikus Putih (Rattus norvegicus) Rahmat Ismail; Hamidah Sri Supriati; Nurul Hastuti Raun
Jurnal Sains dan Kesehatan Vol. 5 No. 1 (2021): Juni : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (154.473 KB) | DOI: 10.57214/jusika.v5i1.181

Abstract

Fever can be interpreted as a body temperature that is higher (>37°C) than normal temperature because of the temperature control center in the hypothalamus, the temperature control center balances temperature during health or fever by regulating the formation and release of heat. For this reason, the purpose of this study was to determine the antipyretic effectiveness of various concentrations of extracts. In this study, 5% peptone was used to induce fever in 15 white rats which were divided into 5 treatment groups. Groups 1 was given 1% NaCMC as a negative control, groups 2 was given paracetamol 9 mg/200gBB) as a positive control, groups 3 was given 10% lire leaf extract (2 mg/200gBB), groups 4 was given 20% lire leaf extract (4 mg/200gBB), and groups 5 was given 40% lire leaf extract (8 mg/200gBB). This results of this study obtained extract levels of 7,44% and there was a weak antipyretic effect at concentrations of 10% and 20% lire leaf extract, while the greatest antipyretic effect was found in 40% lire leaf extract, almost comparable to 9 mg paracetamol.
Co-Authors Hamidah Sri Supriati Rahmat Ismail