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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Dwi Retnoningrum
Diponegoro University
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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Correlation between Lipid Accumulation Product with Fasting Blood Glucose and CRP in Obese Females Natra Dias Surohadi; Dwi Retnoningrum; Meita Hendrianingtyas; Etika Ratna Noer; Ahmad Syauqi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 29, No 1 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i1.1964

Abstract

Obesity is an excessive fat accumulation due to an imbalance between energy intake and consumption. Central obesity, represented by an increase in Waist Circumference (WC) and waist-to-hip ratio, is a predictor for obesity-related metabolic disorders and has replaced BMI to determine the clinical diagnosis of metabolic syndrome. Lipid accumulation product calculated from WC and fasting triglyceride concentration is presumed to be an alternative to measure excessive lipid accumulation and a marker to predict diabetes or cardiovascular risk. Lipid accumulation product is related to cardiovascular disease, diabetes, and metabolic syndrome and is preferable to BMI to identify diseases. It has been established that obesity and increased visceral adipocytes contribute to increased levels of some inflammatory proteins such as CRP. This study aimed to determine the correlation between LAP with FBG and CRP in obese females. This cross-sectional study involved female with obesity aged 35-50 years at Diponegoro National Hospital, Semarang, carried out from February to May 2021. Lipid accumulation product was calculated using LAP=(WC[cm]–58)×(TG[mmol/L]), TG and FBG levels were measured with the colorimetric enzymatic method, and CRP levels were analyzed with an immunoturbidimetric method using the chemical analyzer. The correlation between variables was analyzed using Pearson and Spearman correlation tests (p <0.05). CRP and FBG average levels were 3.546±2.6554 mg/dL and 83.1±11.363 mg/dL, respectively. There was a weak positive correlation between LAP with FBG (p=0.033; r=0.262) and LAP with CRP (p=0.04; r=0.251). Therefore, lipid accumulation products might influence FBG and CRP levels in the obese population
Correlation between Neutrophil to Monocyte Ratio, C-Reactive Protein, and D-dimer Levels among COVID-19 Patients Melkior Krisna Arondaya; Banundari Rachmawati; Santoso Jaeri; Dwi Retnoningrum
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 2 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i2.1992

Abstract

COVID-19 is a disease caused by the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) and leads to various clinical manifestations. This condition can cause inflammation and cardiovascular disease that can result in increased Neutrophil-to-Monocyte Ratio (NMR), C-Reactive Protein (CRP), and D-dimer. The correlation between variables needs further investigation that can be a reference. This study aimed to analyze the correlation between NMR and CRP also NMR and D-dimer in COVID-19 patients with moderate dan severe illness. The research was an observational analytical study with a cross-sectional design on 40 subjects.  Data were secondary data from COVID-19 patient’s medical records in RSND Semarang. This study was carried out from April to September 2021. Correlation analysis using the Spearman Rank test with p<0.05 was considered significant. The Mean of NMR, CRP, and D-dimer was 16.69±10.65, 113.94±70.42 mg/L, and 1.72±2.35 mg/L, respectively. There was a weak positive correlation between NMR and CRP (p=0.023 and r=0.358) and there was no correlation between NMR and D-dimer (p=0.638 and r=0.077). It was expected that this knowledge about the correlation between NMR and CRP and D-dimer can help healthcare providers in planning therapy and preventing complications that may occur due to CRP and D-dimer increase.
Correlation between Lipid Accumulation Product with Fasting Blood Glucose and CRP in Obese Females Natra Dias Surohadi; Dwi Retnoningrum; Meita Hendrianingtyas; Etika Ratna Noer; Ahmad Syauqi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 1 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i1.1964

Abstract

Obesity is an excessive fat accumulation due to an imbalance between energy intake and consumption. Central obesity, represented by an increase in Waist Circumference (WC) and waist-to-hip ratio, is a predictor for obesity-related metabolic disorders and has replaced BMI to determine the clinical diagnosis of metabolic syndrome. Lipid accumulation product calculated from WC and fasting triglyceride concentration is presumed to be an alternative to measure excessive lipid accumulation and a marker to predict diabetes or cardiovascular risk. Lipid accumulation product is related to cardiovascular disease, diabetes, and metabolic syndrome and is preferable to BMI to identify diseases. It has been established that obesity and increased visceral adipocytes contribute to increased levels of some inflammatory proteins such as CRP. This study aimed to determine the correlation between LAP with FBG and CRP in obese females. This cross-sectional study involved female with obesity aged 35-50 years at Diponegoro National Hospital, Semarang, carried out from February to May 2021. Lipid accumulation product was calculated using LAP=(WC[cm]–58)í—(TG[mmol/L]), TG and FBG levels were measured with the colorimetric enzymatic method, and CRP levels were analyzed with an immunoturbidimetric method using the chemical analyzer. The correlation between variables was analyzed using Pearson and Spearman correlation tests (p <0.05). CRP and FBG average levels were 3.546±2.6554 mg/dL and 83.1±11.363 mg/dL, respectively. There was a weak positive correlation between LAP with FBG (p=0.033; r=0.262) and LAP with CRP (p=0.04; r=0.251). Therefore, lipid accumulation products might influence FBG and CRP levels in the obese population
Co-Authors Ahmad Syauqi Banundari Rachmawati Etika Ratna Noer Meita Hendrianingtyas Melkior Krisna Arondaya Natra Dias Surohadi Santoso Jaeri