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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jember Medical Journal (JMJ)
Muhammad Haikal Supriyadi
Universitas Jember
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Subchronic exposure to Chlorpyrifos, Carbofuran, and Cypermethrin increase sciatic nerve damage and degeneration in adolescent rats Muhammad Ihwan Narwanto; Muhammad Haikal Supriyadi; Desie Dwi Wisudanti
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 7 No 1 (2023): Qanun Medika Vol 07 No 01 January 2023
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v7i1.13666

Abstract

Several types of pesticides that are often used are chlorpyrifos (organophosphate), carbofuran (carbamate), and cypermethrin (pyrethroid).  Pesticides can kill pests but also can cause toxic effects on humans when exposed.  One of the adverse effects of pesticide exposure is a disturbance in the peripheral nervous system.  Age is an essential factor in peripheral nerve damage.  Nerve injury is one of the most common injuries in children and adolescents and is estimated at 10% to 15% of all exceptional unit cases.  However, the outcome of peripheral nerve injury is known better in subjects who sustain the injury at a younger age.  This study aims to determine the subchronic exposure effect of chlorpyrifos, carbofuran, and cypermethrin to sciatic nerve histopathology in juvenile rats.  This study used 30 male Wistar rats (Rattus norvegicus) which were divided into 5 groups, normal group (N), control group (K), chlorpyrifos group (P1), carbofuran group (P2) and cypermethrin group (P3).  Subcutaneous injection of pesticides was carried out for 21 days.  Rats were sacrificed using the cervical dislocation method, and the right sciatic nerve was taken for histopathological observation.  Assessment of the degree of ischiatic nerve histopathological damage is using the Jensen et al., (2018) method.  Data were analyzed using the Kruskal-Wallis test and continued with the Mann-Whitney test.  This study showed a significantly increased degree of histopathological damage in the chlorpyrifos group, carbofuran group, and cypermethrin group compared to the control group and the normal group (p<0.05).  It can be concluded that exposure to chlorpyrifos, carbofuran, and cypermethrin pesticides increased damage and degeneration of the ischiadicus nerve in juvenile rats.
A Stillborn Baby with Tetra-amelia Syndrome in Jember: A Case Report Suseno, Daniel Alexander; Baswedan, Achmad Haykal; Putra, Muhamad Dwi Eka; Supriyadi, Muhammad Haikal; Pangestu, Wahyuning
Jember Medical Journal Vol. 3 No. 2 (2024): .
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jembermedicaljournal.v3i2.1057

Abstract

Tetra-amelia syndrome is a rare congenital disorder characterized by the absence of all four extremities. This extremity disorder occurs in 1 in 1,300 to 2,000 births. This condition is caused by genetic mutations in the WNT3 and RSPO2 genes. Specific risk factors for tetra-amelia syndrome remain unclear. This is also due to the lack of studies that discuss specific risk factors for tetra-amelia syndrome. In this case report, we discuss a stillborn baby with tetra-amelia syndrome to a mother with various pregnancy risk factors in Jember. This case report aims to examine the presence of several risk factors in the mother and their relationship with congenital disorders, especially tetra-amelia syndrome.
Co-Authors Baswedan, Achmad Haykal Desie Dwi Wisudanti M. Ihwan Narwanto Pangestu, Wahyuning Putra, Muhamad Dwi Eka Suseno, Daniel Alexander