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All Journal Jurnal Riset Kefarmasian Indonesia PROFESSIONAL HEALTH JOURNAL
Ima Fitria Lestari
STIKES Banyuwangi
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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UJI EFEK ANALGESIK EKSTRAK DAUN SIRIH HIJAU BANYUWANGI (Piper betle L.) PADA MENCIT PUTIH JANTAN (Mus musculus) Ima Fitria Lestari; Junieta Fara Syafirah; Dita Amanda Deviani
Jurnal Riset Kefarmasian Indonesia Vol 5 No 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.351

Abstract

The content of flavonoid compounds in betel leaf is used as a protection as analgesic. The purpose of this study was to test the analgesic effects of Banyuwangi green betel leaf extract (Piper betle L.) on male white mice (Mus musculus). The doses of green betel leaf ethanol extract that were used were 4.696 mg, 9.392 mg and 18.784 mg and the positive control were mefenamic acid. The test animals used in this study were white male mice (Mus musculus) that were adapted for about 3 days in experimental environmental conditions. Based on the results of the study, the analgesic effect test of green betel leaf extract (Piper betle L.) can provide analgesic effectiveness on mice (Mus musculus). Ethanol extracts of green betel leaf (Piper betle L.) at doses of 4.696 mg/kgBW were able to provide a good analgesic effect with good responses to white male mice (Mus musculus). The percentage of analgesic power that was close to the percentage of analgesic power of the gold standard which is 69.23%.
Variasi Kadar AvicelPH101 dan Aerosil Terhadap Kadar Air Serbuk Bunga Telang (Clitoria ternatea L.) ima fitria lestari; Erma Pujiawati; Muhammad Rofik Usman
PROFESSIONAL HEALTH JOURNAL Vol 4 No 2 (2023): Juni
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (PPPM) STIKES Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/phj.v4i2.343

Abstract

Abstract Background: Banyuwangi has the potential of diverse natural resources. One example of the potential plant that can be utilized is butterfly pea (Clitoria ternatea L.). The contents of butterfly pea are phenolic acids, stilbenes (phytoalexins), flavanols, anthocyanins, flavonols and flavanones, polyphenols and flavonoids. In this research, preparations were developed from butterfly pea extract into powder form to make it more practical. The problems occur in making formulations usually have physical characteristics of being thick or liquid making it difficult to formulate into solid dosage forms, so in its manufacture additional ingredients or adsorbents were needed to dry the extract so it is easy to formulate. Avicel pH 101 and aerosil is a combination used as an adsorbent in the manufacture of powders. Aim: This study aimed to determine the effect of Avicel PH101 and Aerosil variations through the results of evaluating the moisture content of butterfly pea ethanol extract powder. Method: This study was a laboratory experiment that began with maceration of butterfly pea simplicia using 70% ethanol and then evaporated to obtain a thick extract of butterfly pea. The preparation of butterfly pea powder was carried out using a combination of Avicel pH 101 and aerosil which was varied in four formulas, namely FI (20%:20%), FII (50%:20% ), FIII (90%:0%), FIV (90% :20%) ). Results: The evaluation results of the water content test that met the requirements were FII(50%:20%) with a moisture content of 2.4%, FIII(90%:0%) with a moisture content of 2.8% and FIV (90%;20%) was the most optimal formulation of Avicel PH101 and Aerosil combination for the manufacture of butterfly pea powder with a moisture content of 1.5% and organoleptically in the form of a powder obtained was very dry and delicate. Keywords: Aerosil, Avicel PH101, Butterfly Pea Powder, Moisture Content.
Co-Authors Dita Amanda Deviani Erma Pujiawati Junieta Fara Syafirah Mohammad Rofik Usman