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All Journal Journal of Pharmaceutical and Health Research
Jumina Jumina
Universitas Gadjah Mada, Yogyakarta
Health Professions Medicine & Pharmacology Nursing Public Health

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C-4-metoksifenilkaliks[4]pirogalaril Dodekasinamat: Sintesis dan Uji Pendahuluan sebagai Bahan Aktif Tabir Surya Harizal Harizal; Jumina Jumina; Tutik Dwi Wahyuningsih
Journal of Pharmaceutical and Health Research Vol 3 No 3 (2022): October 2022
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v3i3.2819

Abstract

Synthesis and preliminary study of C-4-methoxyphenyl[4]pyrogallaryl dodecacinnamate were successfully performed. Synthesis of target molecule was conducted in two steps including preparation of calix[4]pyrogallarene derivative, and O-cinnamoylation of the calix[4]pyrogallarene. The product obtained was pre-evaluated as sunscreen active compound through UV spectroscopy (UV absorbance profile, maximum wavelength, and molar absorption coefficient), and photostability tests. The results of evaluation indicated dominant absorbance in UVC/UVB region with exceptionally high molar absorption coefficient. In other side, target molecule has relatively low photostability in which the UV absorbance decreased 47% after 30 minutes irradiation. The main factor for this lowering was due to the close distance between each cinnamate groups.
Co-Authors Harizal Harizal Tutik Dwi Wahyuningsih