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All Journal Jurnal Kesehatan Junior Medical Journal
Restu Syamsul Hadi
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Religion Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Medicine & Pharmacology Public Health

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The Effect of Honey (Apis Mellifera) Fermentation On Cisplatin Induced Hepatic Histology of Rats and The Review According to Islamic Perspective Fakhria Mutia; Restu Syamsul Hadi; Firman Arifandi
Junior Medical Journal Vol 1, No 2 (2022)
Publisher : Junior Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (804.654 KB) | DOI: 10.33476/jmj.v1i2.2890

Abstract

Background: Cancer is one of the main killer diseases in the world. Cancer must be treated properly. The most common cancer treatment is chemotherapy. Cisplatin is one of the chemotherapy drugs used because of its wide efficacy for the treatment of various types of cancer. Side effects of cisplatin include ototoxicity, nephrotoxicity, hepatotoxicity, neurotoxicity and bone marrow depression. Therefore, there is a need for a solution that can reduce the side effects of cisplatin. One of the natural ingredients that can reduce the side effects of cisplatin is honey. Methods: This research is in the form of primary data, the data is taken directly by conducting an in vivo experiment. This study was divided into 4 groups, namely the untreated group, the cisplatin treatment group only, the cisplatin treatment group with 5% honey fermentation and the cisplatin treatment group with 10% honey fermentation. After that, HE staining was performed to see the histopathological picture of liver cells. Results: Fermentation of honey can reduce the size of congestion and hemorrhage from liver cells exposed to cisplatin. Conclusion: Fermented honey can protect the liver from the toxic effects of cisplatin exposure. In the view of Islam, treatment is one of the efforts in getting the gift of healing from Allah Subhanahu wa Ta'ala. Islam and medicine agree on the importance of this research to support the goals of Islamic law, namely Maqashid Syari'iyah.
Konsentrasi Basic Fibroblast Growth Factor (bFGF) dan Transforming Growth Factor-Beta 1 (TGF-β1) pada Penyembuhan Luka Kulit Tikus Anggi Puspa Nur Hidayati; Wira Alwysaputro; Afif Ramdisa; Restu Syamsul Hadi
Jurnal Kesehatan Vol 11 No 1 (2023): April 2023
Publisher : Politeknik Negeri Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25047/j-kes.v11i1.337

Abstract

Acceleration of wound healing is now becomes a trend center for many researcher to explore various herbs which are containing compounds that can affecting some factors involved in wound healing process. Growth factors is one of the marker that can be analyzed whether a certain herb can accelerate wound healing. To better understand how a certain herb invloved in the acceleration of wound healing, a growth factors-study was conducted. Archived skin tissue of rats from previous study (unpublished) which were been treated with Anredera cordifolia (Binahong) extract were used, and subjected to enzyme-linked immunosorbent assay (ELISA) to quantify bFGF and TGF-β1. The results obtained was then analyzed descriptively between the control group (Binahong-untreated) and treatment group (Binahong-treated). The ELISA results showed no siginificant difference of bFGF and TGF-β1 concentration between control group (Binahong-untreated) and treatment group (Binahong-treated). However, the concentration of bFGF dan TGF-β1 on day 14 were decreasing compared with those concentration on day 7, assumed the wound healing phase has already entering the next phase where the production of bFGF and TGF-β1 have been replaced with other growth factors involved in wound healing process
Co-Authors Afif Ramdisa Anggi Puspa Nur Hidayati Fakhria Mutia Firman Arifandi Wira Alwysaputro