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All Journal Biology, Medicine, & Natural Product Chemistry
Elfred Rinaldo Kasimo
Kadiri University
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Interleukin-1 as a Predictor Cytokine SARS-CoV: Article Review Lisa Savitri; Elfred Rinaldo Kasimo; Rochmad Krissanjaya; Syntia Tanu Juwita; Ester Lianawati Antoro; Ida Septika Wulansari
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.187-190

Abstract

Severe acute respiratory syndrome coronavirus (SARS-CoV) is an etiologic agent of respiratory disease that has a mortality rate of 10%. IL-1 actively participates in the inflammatory response to infection. SARS-CoV-2 appears to act on the activation and maturation of IL-1?, which in turn activates other proinflammatory cytokines, such as IL-6 and TNF-. Therefore, IL-1? is part of the cytokine storm generated by coronavirus infection. Elevated levels of the IL-1 receptor antagonist (IL-1Ra) in severe cases of COVID-19, and this marker have been associated with increased viral load, loss of lung function, lung damage, and risk of death. In addition, there is an increase in IL-1? levels in patients with severe COVID-19, and this is strongly associated with lung injury. IL-1 levels are associated with the virulence of the process, and significantly higher serum levels have been observed in severe symptomatic SARS-CoV-2 cases than in mild cases or in those infected with the 2003 SARS-CoV coronavirus or 2012 MERS coronavirus.
Effect of Ciprofloxacin Administration on Gastric Histopathological Changes in Mice Lisa Savitri; Kharisul Ihsan; Rochmad Krissanjaya; Elfred Rinaldo Kasimo; Novirma Yanti; Mochamad Hanif Hilmi
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.873-878

Abstract

Ciprofloxacin is a fluoroquinolone antibiotic widely used in clinical and veterinary practice. While effective against a broad range of bacterial infections, several studies have reported potential adverse effects on the gastrointestinal tract, particularly the gastric mucosa. This study aimed to evaluate the histopathological changes in the gastric mucosa of mice following ciprofloxacin administration at different doses. A total of 24 male mice were randomly divided into four groups: control, low-dose ciprofloxacin, moderate-dose ciprofloxacin, and high-dose ciprofloxacin. Treatment was administered orally for 14 days. Gastric tissues were collected and examined histologically using hematoxylin-eosin staining. Histopathological analysis revealed dose-dependent mucosal alterations. The control group showed intact gastric architecture, while the low-dose group exhibited mild epithelial erosion. The moderate-dose group presented with mucosal disruption and inflammatory infiltration, and the high-dose group demonstrated severe ulceration, edema, and mucosal thinning. These findings indicate progressive gastric injury with increasing ciprofloxacin exposure. Ciprofloxacin administration induces dose-dependent gastric mucosal injury in mice, consistent with fluoroquinolone-related gastrointestinal toxicity. Caution is warranted in prolonged or high-dose therapy, and further studies are needed to explore the underlying mechanisms and potential gastroprotective interventions.
Study of Sperm Utilization in Female Drosophila melanogaster of bdp and btx Strains Lisa Savitri; Kharisul Ihsan; Elfred Rinaldo Kasimo; Rochmad Krissanjaya
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1151-1157

Abstract

This study investigates the patterns of sperm utilization in female Drosophila melanogaster of the bdp and btx strains through sequential mating with multiple males. The research was conducted as a descriptive observational study without experimental manipulation. Females of each strain were crossed with four different males in a specific order, with a two-day interval between each mating. F1 offspring phenotypes were recorded daily over a six-day period following the final mating. Data were analyzed descriptively and supported by somatic chromosome reconstruction to identify the male origin of each offspring. The results indicate that sperm utilization in D. melanogaster females occurs in both random and non-random patterns. Non-random utilization was observed when offspring were produced exclusively from the first male, with no contribution from subsequent males. For example, in the female btx × male N cross, only N female and N male offspring were produced, indicating that sperm from the first male was preferentially used. In contrast, random sperm utilization was evident in later matings, where offspring from multiple males appeared, suggesting that previously stored sperm remained viable and were used alongside or instead of sperm from later matings. These findings highlight the complexity of post-mating sexual selection in D. melanogaster, particularly the role of female sperm storage and utilization mechanisms. The ability of females to either favor the sperm of a particular male or mix sperm from several males may provide evolutionary advantages in terms of genetic diversity and offspring fitness. This study contributes to a better understanding of reproductive strategies and sperm competition in insects, with potential implications for broader studies in evolutionary biology and genetics.
Co-Authors Ester Lianawati Antoro Ida Septika Wulansari Kharisul Ihsan Lisa Savitri Mochamad Hanif Hilmi Novirma Yanti Rochmad Krissanjaya savitri, Lisa Syntia Tanu Juwita