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Dwimantoro
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Medicine & Pharmacology Public Health

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The Role of Syzygium Polyanthum Leaf Extract in Reducing Renal Cell Damage with Potassium Oxonate-Induced Hyperuricemia Dwimantoro; Hotimah Masdan Salim; Aditya Bhayusakti; Dayu Satriya Wibawa
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 11 No. 2 (2022): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v11i2.19229

Abstract

Abstract. Background: Kidney is an organ that plays an important rolein regulating homeostasis, excrete the foreign or toxic substances, andmetabolism product such as uric acid, urea, and creatinine in the bodythrough the urine. Syzygium polyanthum, has been used in loweringuric acid levels. The purpose of this research is to tested the effect ofbay leaf extract on kidney histopathology of hyperuricemia inducedmice model of potassium oxonate. Methods: This study is a laboratoryexperimentalstudy with a post-test only control group design, and wasdivided into a control group, a hyperuricemia (PO) group, an PO groupwith 75 mg/kg bay leaf extract, an PO group with 150 bay leaf extractand an PO group with 300 mg/kgBW bay leaf extract. The treatmentwas given for 14 days then histopathological examination of thekidneys was carried out with HE staining. Results: Histopathologicalinflammation occurred in all groups and necrosis was the most severefound in the positive control group where the administration of bayleaf extractsignificantly reduced inflammatory cellsfrom the lowest tothe highest dose with P < 0.001. Conclusion: Administration ofSyzygium polyanthum affected renal histopathology in potassiumoxonate-induced hyperuricemic mice.
Profil Deskriptif Pasien dengan Apendisitis Akut di Rumah Sakit Islam Jemursari Dayu Satriya Wibawa; Aditya Bhayusakti; Dwimantoro; Hotimah Masdan Salim; David Sajid Muhammad
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 13 No. 1 (2024): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v13i1.21816

Abstract

Latar Belakang: Apendisitis merupakan penyebab nyeri perut bawah dan sering menyebabkan kunjungan ke Unit Gawat Darurat. Apendisitis disebabkan oleh obstruksi luminal akibat berbagai etiologi sehingga meningkatkan produksi mukus dan pertumbuhan bakteri berlebih. Penelitian ini bertujuan untuk mengetahui profil penderita apendisitis akut di RSIS Jemursari Surabaya. Metode: Penelitian ini merupakan penelitian deskriptif analitik dengan crossectional dengan menggunakan data sekunder dari rekammedis periode 2022. Data didapatkan dari rekam medis pasien yang didiagnosis dengan apendisitis akut. Hasil: Rerata usia pada penelitian ini yaitu 19% adalah usia remaja akhir, dengan jenis kelamin terbanyak yaitu terjadi pada perempuan 73,7%. Adapaun pemeriksaan hematologi didapatkan leukositosis sebanyak 57,9% dengan kadar hemoglobin normal sebesar 47,4%. Kesimpulan pada penelitian ini yaitu Apendisitis akut dialami sebagian besar oleh perempuan. Dilihat dari jumlah leukosit, rata-rata pasien mengalami leukositosis. Kata Kunci :Apendisitis akut, Profil, RSI Jemursari
Co-Authors Aditya Bhayusakti David Sajid Muhammad Dayu Satriya Wibawa Salim, Hotimah Masdan